The invention belongs to the technical field of cosmetics, and in particular relates to an anti-wrinkle cleansing lotion and a preparation method thereof. The anti-wrinkle cleansing lotion consists of myristic acid, palmitic acid, stearic acid, glycerol, potassium hydroxide, sodium taurine laurate, sodium cocoyl glycinate, sodium lauroyl glutamate, C12-14 secondary-chain alkanol polyether-20, glycol distearate, propanediol, lactobacillus / punica granatum fruit fermentation product extract, arctic chlamydomonas essence, starfish essence, cortex acanthopanacis essence, a pearl extract, EDTA-Na2, hydroxypropyl methyl cellulose, methyl hydroxybenzoate, propyl hydroxybenzoate, methylisothiazolinone, essence and water. The anti-wrinkle cleansing lotion disclosed by the invention is gentle and skin-friendly, safe and non-irritant; and the cleansing lotion is capable of deeply cleansing skin, and meanwhile the cleansing lotion is capable of moisturizing and resisting wrinkles.