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Synthetic method of laurel acyl amino acid sodium

A technology of sodium lauroyl amino acid and lauroyl amino acid, which is applied to the synthesis of sodium lauroyl amino acid prepared from lauroyl chloride, and the synthesis field of sodium lauroyl amino acid, and achieves the effects of good product quality, reasonable process and high reaction yield.

Active Publication Date: 2013-01-16
CHANGSHA PUJI BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no report on the production of lauroyl chloride by the phosgene method, and then the preparation of sodium lauroyl amino acid from the resulting acid chloride

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] In a 500mL four-necked flask equipped with a thermometer, a reflux condenser, an air guide tube, and agitation, add 200g (1mol) of lauric acid and 1.5g (0.02mol) of N,N-dimethylformamide, and raise the temperature to 60°C. The reaction temperature is 70-80°C, and within 5-10 hours, 110g (1.1mol) of phosgene is introduced. After the reaction is completed, vacuum distillation is carried out, and fractions at 140-160°C (1333Pa) are collected to obtain 196.5g of lauroyl chloride, with a yield of 90%. .

[0023] In a 1000mL four-necked flask equipped with a thermometer, a dropping funnel, and stirring, add 191g (1mol) of glutamic acid, dissolve it in 570g of water, stir it at room temperature to dissolve it completely, and make a 25% aqueous solution. Add 240g of lauroyl chloride (1.1mol) into a dry dropping funnel, control the temperature in an ice-water bath at 15-20°C, add lauroyl chloride under stirring, and add 25% aqueous sodium hydroxide solution dropwise at the same ...

Embodiment 2

[0026] Lauroyl chloride is synthesized with embodiment 1.

[0027] In a 1000mL four-neck flask equipped with a thermometer, a dropping funnel, and stirring, add 111g (1mol) of sarcosine, dissolve it in 333g of water, stir at room temperature to dissolve it completely, and make a 25% aqueous solution, and add 240g of lauroyl chloride (1.1mol) into a dry dropping funnel, control the temperature in an ice-water bath at 15-20°C, add lauroyl chloride under stirring, and add 25% aqueous sodium hydroxide solution dropwise at the same time to keep the reaction solution at pH= 8 to 10, until the addition is complete; continue to react for 4 to 5 h. After the reaction, the pH value was adjusted to 1-2 with 6N hydrochloric acid, and a large amount of white crystals were precipitated. After the product was completely precipitated, it was filtered and dried to obtain 260 g of lauroyl sarcosine with a yield of 96%.

[0028] Dissolve 271g (1mol) of lauroyl sarcosine in 608g of ethanol, add ...

Embodiment 3

[0030] Lauroyl chloride is synthesized with embodiment 1.

[0031]In a 1000mL four-neck flask equipped with a thermometer, a dropping funnel, and stirring, add 97g (1mol) of glycine, dissolve it in 291g of water, stir at room temperature to dissolve it completely, and make a 25% aqueous solution. Add 240g (1.1 mol) into a dry dropping funnel, control the temperature in an ice-water bath at 15-20°C, add lauroyl chloride under stirring, and at the same time add 25% aqueous sodium hydroxide solution dropwise to keep the reaction solution at pH = 8- 10, until the addition is complete; continue to react for 4 to 5 h. After the reaction, the pH value was adjusted to 1-2 with 6N hydrochloric acid, and a large amount of white crystals were precipitated. After the product was completely precipitated, it was filtered and dried to obtain 244 g of lauroyl glycine with a yield of 95%.

[0032] Dissolve 257g (1mol) of lauroylglycine in 458g of ethanol, add 200g of ethanol solution of 20% s...

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PUM

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Abstract

The invention relates to a synthetic method of lauric acyl amino acid sodium, particularly to a synthetic method which uses lauric acid and phosgene as raw materials. The synthetic method comprises the following steps: ensuring that the reaction lasts for 1 to 20 hours at a temperature of 60 to 100 DEG C with the effect of organic amide catalyst; obtaining acyl chloride through vacuum distillation after the reaction is finished; dripping lauric acyl chloride obtained according to the phosgene method into amino acids alkaline solution for reaction; controlling and ensuring the pH value to be within the range of 8 to 10, the reaction temperature to be 15 to 20 DEG C, and the reaction time to be 4 to 5 hours; carrying out cooling after the reaction is finished; acidizing the reaction solution to pH 1 to 2 with hydrochloric acid solution; filtering, washing and drying white sediment to obtain lauric acyl amino acid; dissolving the prepared lauric acyl amino acid with alcohol; adding alcohol solution with sodium hydroxide of equal molar amount; and crystallizing, sucking, filtering and drying after cooling to obtain the lauric acyl amino acid sodium. According to the invention, the synthetic method is reasonable in process, high in reaction efficiency and good in product quality; the three wastes are seldom generated; and no residual phosphorus and sulfur are contained in the product. Therefore, the synthetic method can be widely used in the production of high-end surface active agents, and has significant utility value and social and economic benefits.

Description

technical field [0001] The invention relates to a synthetic method of sodium lauroyl amino acid in the field of surfactants, in particular to a synthetic method for preparing sodium lauroyl amino acid from lauroyl chloride synthesized by a phosgene method. Background technique [0002] Sodium lauroyl amino acid is a kind of amino acid type anionic surfactant, which has good washing, dispersing, emulsifying, penetrating, solubilizing and other characteristics; its wettability is better than that of fatty alcohol polyoxyethylene ether (AE); it has superior foaming It is non-toxic, and the foam is delicate and long-lasting, which is better than the foaming agent sodium lauryl sulfate (K12) commonly used in toothpaste; it has antibacterial, bactericidal, anti-corrosion, and anti-static capabilities; it has good compatibility and can form with cationic surfactants Transparent solution, does not produce resistant precipitation, and retains the characteristics of cationic surfactan...

Claims

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Application Information

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IPC IPC(8): C07C233/47C07C231/02
Inventor 李耀莲
Owner CHANGSHA PUJI BIOTECH
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