448results about How to "Suitable for industrial scale-up production" patented technology

The invention discloses a nitrogen doped carbon quantum dot as well as a preparation method and an application thereof, belonging to the technical field of material science. The preparation method comprises the steps: after mixing organic acid and organic amine, directly performing a hydrothermal reaction to prepare a nitrogen doped carbon quantum dot water dispersion solution, and extracting and drying the nitrogen doped carbon quantum dot water dispersion solution to obtain a nitrogen doped carbon quantum dot solid. The size of the nitrogen doped carbon quantum dot is not more than 10 nm, the nitrogen content is not more than 50 percent, the surface of the nitrogen doped carbon quantum dot contains amino, carboxyl and hydroxyl; and the quantum efficiency is 39.8-50 percent. The preparation method is simple to operate, environment-friendly, low in equipment requirement; and the prepared nitrogen doped carbon quantum dot has excellent light emitting property, and can be widely applied to fields such as photoelectric materials, biological imaging and fluorescence probe.

The invention belongs to the technical field of mesoporous composite materials, and particularly relates to a three-dimensional interconnected hierarchical-structured zeolite molecular sieve material and a preparation method thereof. The method comprises the following steps of: self-assembling anionic and cationic surfactants, serving as primary constitutional units, in solution phase to form a secondary constitutional unit; self-assembling in solution to be compounded into amphipathic block copolymer; then, self-assembling in the solution by taking the amphipathic block copolymer as a template agent and by using a structural guide agent and inorganic silicon to obtain a silicon dioxide / surfactant / template agent composite material; and finally, calcining to remove the surfactant and the template agent to obtain the hierarchical-structured mesoporous zeolite molecular sieve material consisting of interconnected mesopores, micropores and macropores. The material has higher specific surface area and stronger hydrothermal stability, and has a broad application prospect in the aspects of petrochemical industry, heavy oil catalysis cracking, biological separation, adsorption and the like. The material obtained in the invention has the advantages of superior performance, simple synthesis method and readily available raw material and is suitable for industrial production.

The invention discloses a low density heat conduction pouring sealant which comprises 100 parts of vinyl silicone oil, 2-20 parts of cross-linking agent, 0.01-0.4 parts of catalyst, 50-300 parts of heat conduction filler, 0-15 parts of reinforcing filler, 10-60 parts of inflaming retarding filler, 5-90 parts of low density filler and 0.001-0.05 part of inhibitor. The sealant has good heat conduction performance, excellent inflaming retarding performance and dynamic performance and low density. Compared with common heat conduction pouring sealant, the sealant achieves the effect that the density is reduced by about 40%, and has wide application prospect in the field of electronic devices, electric automobiles and the like. A preparation method of the low density heat conduction pouring sealant is further provided. The method includes three steps of base material preparation, preparation of a component A and a component B and preparation of the low-density heat conduction pouring sealant. The preparation method is simple in process, short in production period, low in workload and very suitable for industrial large-scale production. The equipment is conventional equipment.

The invention discloses a method for preparing a high-performance Silicalite-1 molecular sieve membrane, which comprises the following steps: using cheap TPABr and silica sol as raw materials for preparing a high-activity Silicalite-1 molecular sieve crystal; using the crystal as a seed crystal to be loaded on the outer surface of a supporting body, and carrying out the high-temperature hydrothermal crystallization in the diluted synthetic liquid using TPABr as the template agent to obtain the high-performance Silicalite-1 molecular sieve membrane. The invention is characterized by adopting asecondary growth hydrothermal method and carrying out the high-temperature (180-210 DEG C) hydrothermal one-step synthesis of the diluted synthetic liquid using TPABr as the template agent (300-750 ofH2O / SiO2, 0.1-0.5 of TPABr / SiO2, and 0.1-0.5 of NaOH / SiO2) on the surface of a porous tubular mullite carrier to form the high-performance Silicalite-1 molecular sieve membrane. The method not only effectively uses the cheap TPABr to replace TPAOH to prepare the molecular sieve membrane, but also greatly reduces the demand quantity of the silicon source and the template agent in the membrane synthetic liquid, thereby greatly reducing the membrane preparing cost. By applying the prepared Silicalite-1 molecular sieve membrane to a pervaporation test in a 60 DEG C ethanol / water (5 / 95 wt %) mixedsystem, the permeation flux and the separation factor can reach 1.71kg / m<2>.h and 66 respectively. The invention obviously improves the permeation flux and the selectivity of the Silicalite-1 molecular sieve membrane, reduces the production cost and is suitable for industrial production.

The invention relates to a tube-type continuous method for producing polymetaphenylene isophthamide spinning solution, which is characterized in that a method for serially connecting a self-cleaning tubular reactor serving as a condensation reactor and a twin-screw kneading machine serving as a neutralization reactor is adopted for preparing the polymetaphenylene isophthamide spinning solution. The self-cleaning tubular reactor solves the problems that side reactions are increased due to quick generation of heat in the reaction and the polymer molecular weight cannot be improved; and the twin-screw kneading machine solves the problem of poor dissolution of solid granules in the spinning solution caused by nonuniform liquid / solid kneading in the neutralization process. The preparation method comprises the steps of pre-condensation, condensation, neutralization, and forced extrusion and filtration. The solid content of the final spinning solution is 14 to 20 percent; and calcium hydroxide is adopted for neutralization by one step, and the calcium chloride content is 6.5 to 9.3 percent. If the calcium hydroxide and sodium hydroxide are adopted for neutralization by two steps, the calcium chloride content can be less than 3 percent. Therefore, the method is also suitable for producing spinning solution for a high salt method and a low salt method.

The invention discloses a method for producing pyrroloquinoline quinine through microbial fermentation and a fermentation medium used in the method for producing the pyrroloquinoline quinine through the microbial fermentation. An oxygen control fermentation culture method is used for culturing methylotrophic bacteria, a carbon source contained in the fermentation medium is methyl alcohol, and a nitrogen source contained in the fermentation medium is ammonium sulfate, a dissolved oxygen level is controlled by stages to be 30%-50% of saturated dissolved oxygen in the fermentation process, pH is controlled to be 5.5-6.0 through fed-batch, the fed-batch is achieved through a pH-nitrogen source joint control technology, the methylotrophic bacteria are cultured for six days in a 7.5L fermentation tank, and eventually the cell density (OD 600) exceeds 10, yield of PQQ reaches 2g / L, and production intensity of the PQQ is 333.33mg / L / day. The method for producing the pyrroloquinoline quinine through the microbial fermentation is simple in operation, automatic control and continuous fermentation can be achieved easily, and a solid foundation for industrially producing the pyrroloquinoline quinine through the methylotrophic bacteria is laid.

The invention discloses a method for extracting buckwheat flavone from buckwheat bran. A method of combining enzyme treatment and ultrasonic assistance is adopted for extracting the buckwheat flavone from the buckwheat bran, and in addition, macroporous resin is adopted for purification. The method comprises the following steps of 1) carrying out enzymolysis under the ultrasonic condition: the buckwheat bran is taken and is added with water to be prepared into buckwheat bran turbid liquid, and then, compound enzyme is added for carrying out enzymolysis; 2) centrifugal separation: enzymatic hydrolysate is subjected to centrifugation for collecting precipitates and supernate; 3) ultrasonic alcohol extraction: precipitates are subjected to ultrasonic leaching by ethanol; 4) filtration and concentration: alcohol extraction liquid is filtered and concentrated; 5) purification: the macroporous resin is used for carrying out purification on the concentrated liquid; and 6) drying: buckwheat-flavone-containing fractions obtained through purification are subjected to vacuum drying, and flavone products are obtained. The flavone compound prepared by the method disclosed by the invention has the advantages that the purity is higher, the preparation process is simple, the operation is simple and convenient, the implementation is easy, the environment is friendly, and the flavone compound is suitable for industrial magnification production.

The invention discloses a preparation method of LCZ696 intermediate and relates to the technical field of preparation of an aromatic nucleus compound containing 2 benzene rings and 1 chiral center. The preparation method includes the steps of S1, allowing benzyl magnesium bromide to react with methyl oxalyl chloride to obtain a compound as shown in formula I; S2, allowing the compound as shown in formula I to have a bromination reaction with a bromination reagent to generate a compound as shown in formula II; S3, coupling the compound as shown in formula II with phenylboronic acid to obtain a compound as shown in formula III; S4, performing reductive ammoniation on the compound as shown in formula III to obtain a compound as shown in formula IV; S5, applying Boc to the compound as shown in formula IV to obtain a compound as shown in formula V; S6, performing ester group reduction on the compound as shown in formula V to obtain a compound as shown in formula VI. The preparation method has the advantages that overall raw material consumption is lowered, and product productivity and market competiveness are increased; by the overall process optimization, the reaction of each step can be performed and controlled easily, the use of heavy metal catalysts is reduced and avoided, and accordingly the quality index of the final product is increased, and an economic and environment-friendly process route is developed.

The invention provides an Ezetimibe synthesis method comprising the following steps: (a) a compound (5) is subjected to asymmetric reduction reaction to obtain a compound (6), and the compound (6) and tert-butyldimethylsilyl chloride react in an organic solution under the action of alkali to obtain a compound (7); (b) the compound (7) and diisopropylethylamine are dissolved in the organic solution, titanium tetrachloride is added in the organic solution to react at 20-50 DEG C, and a compound (3) is added in the organic solution at minus 20 to minus 60 DEG C to react to obtain a compound (8); (c) the compound (8) and N,O-bis(trimethylsilyl) acetamide react in the organic solution at 20-80 DEG C, tetrabutylammonium fluoride trihydrate is added into the organic solution to react at 20-80 DEG C to obtain a compound (9); (d) the compound (9) is subjected to off-protection reaction to obtain Ezetimibe, wherein R is equal to TBS, Ac or COOCH2CCl3. The invention further provides an Ezetimibe intermediate and a preparation method thereof.

The invention discloses a preparation method of carboxyl silicone oil. Undecylenic acid and methyl hydrogen dichlorosilane are taken as raw materials to be subjected to direct hydrosilylation in the presence of a platinum / carbon catalyst to obtain 11-carboxyl undecyl methyl dichlorosilane; and the carboxyl silane monomer 11-carboxyl undecyl methyl dichlorosilane and dimethyldichlorosilane are subjected to co-hydrolysis and equilibrium polycondensation to obtain 11-carboxyl undecyl methyl silicone oil. The preparation method has the following advantages: the preparation process of carboxyl silicone oil is simplified by adopting the method for preparing the carboxyl silane monomer by one step through the direct addition reaction; the raw materials adopted for synthesis are industrial raw materials and are suitable for industrial large-scale production; and after being prepared into emulsion and compounded with amino silicone oil emulsion, the prepared carboxyl silicone oil can provide very good softness and full hand feel when being applied to textile finishing.

The invention discloses a cerium zirconium aluminum composite oxide oxygen storage material and a preparation method thereof. According to the cerium zirconium aluminum composite oxide oxygen storage material, the particle size is 5 to 10 nm; the BET specific surface area is 200 to 240 m<2> / g; the pore volume is 0.50 to 0.70 cm<3> / g; the average pore size is 5 to 10 nm; a cerium zirconium solid solution has a stable cubic fluorite structure. The cerium zirconium aluminum composite oxide oxygen storage material provided by the invention has the characteristics of stable structure, large specific surface area, excellent oxygen storage performance and excellent anti-ageing performance. The preparation method provided by the invention has the advantages of easily accessible raw materials and low production cost, and is suitable for industrialized amplification production.

The invention relates to a preparation method and a refining method of medical hemostatic polysaccharide starch. With pretreated potato starch as a raw material and epichlorohydrin as a crosslinking agent, a microsphere adopting a three-dimensional network structure is synthesized by an emulsifying and crosslinking technology. The medical hemostatic polysaccharide starch is high in biocompatibility; the medical hemostatic polysaccharide starch is full with wrinkles on the surface, so that the particle surface area is increased, the water absorbing rate is significantly improved and the hemostatic time is greatly reduced; the medical hemostatic polysaccharide starch is especially applicable to large-area blood seepage, deep bleeding, and bleeding at a part difficult to reach by operative procedures.

The invention discloses a method for synthesizing mirabegron, relates to a method for preparing mirabegron, and aims at solving the problems that the existing method for synthesizing the mirabegron is not friendly to environment, more in reaction steps, low in yield, and complicated in post-treatment, and cannot be amplified to produce. The method disclosed by the invention comprises the following steps: 1, carrying out ring-opening reaction by taking p-nitrophenylethylamine and (R)-phenylethylene oxide as initial raw materials; 2, carrying out reduction reaction; 3 carrying out condensation reaction. The method disclosed by the invention is cheap and available in selected raw materials, high in yield, low in cost, friendly to environment and applicable to industrial amplifying production. The method is applied to synthesis of the mirabegron.

The invention discloses a catalyst for producing hydrogen peroxide by an anthraquinone method and a preparation method thereof. The composition of the catalyst is represented by Pd-MOx / gamma-Al2O3, and M represents a metal element Cr, Zr or Mn. The catalyst can be prepared by adopting an incipient co-impregnation method and a two-step impregnation method, and the hydrogenation activity test of 2-ethyl anthraquinone is performed under the condition that the liquid space velocity is 28.6h<-1>, the hydrogen pressure is 0.18MPa, and the reaction temperature is 45 DEG C. The catalyst has the advantages that the catalyst has high catalytic activity, and the hydrogenation efficiency can reach between 8.0 and 10.0g (H2O2) / L; the catalyst has good selectivity which is more than 99 percent; the catalyst has the simple preparation method; and the catalyst has mild reaction conditions, still keeps high activity at high liquid space velocity, and is suitable for industrial scale-up production.

The invention relates to a zinc oxide based normal-temperature deep desulfurizing agent as well as a preparation method and application thereof. During preparation, a mixed solution of a zinc salt, an aluminum salt and an aid metallic salt is subjected to a one-step coprecipitation reaction to form a compound precipitate; the compound precipitate is subjected to aging, drying and roasting to obtain the zinc oxide based normal-temperature deep compound desulfurizing agent. The prepared zinc oxide based normal-temperature deep desulfurizing agent is used for the normal-temperature deep removal of H2S in various gaseous and liquid materials in the field of petroleum and coal chemical industries; that is, the fixed-bed operation is adopted; in conditions that a reaction temperature is 20 to 60 DEG C and operation pressure is 0.1MPa to 5MPa, the volume space velocity of liquid is controlled to be 1h<-1> to 12h<-1> or a gas-phase space velocity is controlled to be 1,000h<-1> to 30,000h<-1>; the H2s of which the content is 1ppm to 1,000ppm in a to-be-treated material is removed until the content is not more than 0.03ppm. Compared with the prior art, the desulfurizing agent prepared by the preparation method has breakthrough sulfur capacity, which reaches 26.1 percent, at a normal temperature and desulfurization precision which reaches 0.03ppm or below; the preparation method is simple, and can be used for large-scale industrialized production.

The invention relates to condensed polytetrafluoroethylene aqueous dispersion, which comprises 30-65wt% of polytetrafluoroethylene dry material and 3-10wt% of emulsifying agent relative to the polytetrafluoroethylene dry material, wherein the emulsifying agent comprises secondary alcohol ethoxylate emulsifying agent A of which the cloud point is 30-45DEG C, and secondary alcohol ethoxylate emulsifying agent B of which the cloud point is 70-95DEG C, and the mass ratio of the emulsifying agent A to the emulsifying agent B is (2:3)-(3:2). The invention also provides a preparation method for the condensed polytetrafluoroethylene aqueous dispersion and an application of the condensed polytetrafluoroethylene aqueous dispersion to preparing water-based paint. The condensed polytetrafluoroethylene aqueous dispersion provided by the invention has good stability, a film with a thicker coating can be obtained in the processing and applying process, the glossiness can be drastically improved, and the condensed polytetrafluoroethylene aqueous dispersion can be effectively used for various water-based paints. The preparation method provided by the invention has the advantages of simple technology and strong maneuverability and is suitable for industrial large-scale production.

The invention provides an enzymatic pretreatment assisted curcumin extraction technology. The enzymatic pretreatment assisted curcumin extraction technology comprises steps as follows: after 1 part of curcuma powder is taken, ground, sieved, added with water and stirred uniformly, the mixture is subjected to water bath for 60 min and is cooled to the constant temperature of 52-58 DEG C, and curcuma pulp is obtained; compound enzyme comprising cellulase, amylase and papain is added to the curcuma pulp and reacts for 2-4 h, and enzymatic hydrolysate is obtained; the enzymatic hydrolysate is taken, added with an ethanol solution and homogenized for 1-2 min under the condition of 8,000-9,000 r / min, and a curcumin extracting solution is obtained; finally, a flocculant is added to the extracting solution, the mixture is stirred and filtered, a clear liquid flows through an activated carbon chromatographic column and is eluted with an alkaline solution, and a curcumin desorbed solution is obtained. The technology has the advantages of high extraction speed, low temperature, low energy consumption, high yield of the effective component curcumin, stable product quality and controllable reaction conditions, and is applicable to industrial large-scale production.

The invention provides a preparation method of poly-l-lactide particles and a preparation method of an injectable soft tissue filler. The preparation method of the poly-l-lactide particles includes the steps: first, dissolving poly-l-lactide in good solvents to obtain poly-l-lactide solution; second, adding the poly-l-lactide solution into a reactor and adding anti-solvents under the condition ofstirring to separate out the poly-l-lactide particles from reaction solution; third, filtering the reaction solution with suspending poly-l-lactide particles, purifying and drying the reaction solution to obtain the poly-l-lactide particles. The poly-l-lactide particles are prepared by a soap-free good solvent-anti-solvent precipitation method, addition of any emulsifiers and dispersing agents isomitted in the preparation process of the particles, a technological process is simple in operation, and the preparation method is low in production cost, high in production efficiency and suitable for industrial amplified production.

The invention provides a method for synthesizing a nano three-way catalyst and belongs to the technical field of a catalyst preparation process. The method takes a metal organic salt and a commercial carrier as raw materials and comprises the following steps: reacting in a solvent at 60-300 DEG C for 1-720 minutes; and controlling experimental parameters including a mol ratio of reactants, the concentration of the reactants, a reducing agent, a reaction temperature and the like to form the nano three-way catalyst which is formed in series and has controllable structure, shape and size. The method provided by the invention has the advantages that the raw materials are cheap and easy to obtain, time for a reaction is short, the solvent can be repeatedly utilized, the equipment is simple, and the method is easy to realize and control, has good process repeatability and stable product quality, is safe and reliable to operate, and is suitable for industrial large-scale production.

The invention relates to the technical field of small-molecule chemical drug, and particularly relates to a preparation method of a crizotinib intermediate. The preparation method comprises: (1) synthesizing a compound 3 from a compound 1 and a compound 2 by flow chemistry; (2) synthesizing the crizotinib intermediate I from the compound 3 obtained in the step (1) and a boric acid ester compound 4 by flow chemistry. The preparation method of the crizotinib intermediate, which is provided by the invention, is high in yield, can greatly reduce energy consumption and cost in the preparation process of crizotinib, is environmental-friendly, is high in safety and high in automation degree, and is suitable for industrial amplification production. A reaction route is as follows: (with reference to the specification), wherein Y represents a leaving group, Z represents an amino protection group, and X is selected from F, Cl, Br and I.

The invention relates to a Vinorelbine long circulation liposome preparation and a preparation method thereof, the preparation comprises three sub-packaging units, i.e. an empty liposome, sodium phosphate buffer solution and heavy tartaric acid Vinorelbine; and before being used, the three sub-packaging units are mixed together and heated appropriately. The preparation method has the advantages of simple process and easy operation and is suitable for industrial production, and the Vinorelbine long circulation liposome which is prepared by adopting the method has high encapsulation rate and good stability.

The invention belongs to the technical field of waste battery treatment, and particularly discloses a waste lithium ion battery recovery method. A to-be-recovered raw material containing a waste positive electrode active material and an auxiliary agent are roasted at 500-800 DEG C, and then water extraction treatment is performed; and the auxiliary agent is at least one of NaHSO4, KHSO4, CoSO4, NiSO4, MnSO4, NH4HSO4 and (NH4)2SO4. The method overcomes the disadvantages of a traditional recovery method, is simple, practical and economically feasible, realizes comprehensive utilization of wastelithium ion batteries, and is suitable for industrial production.

The invention discloses a method for synthesizing ultrathin molybdenum disulfide nanocrystals and belongs to the technical field of inorganic material preparation processes. According to the method, a molybdenum-containing inorganic salt and a sulfur-containing compound or sulfur powder are used as raw materials and have a reaction at the temperature of 160-300 DEG C for 30-120 min in a long-chain amine solvent and a long-chain fatty acid surfactant, experiment parameters such as the reactant molar ratio, the reactant concentration, the reaction temperature, the reaction time and the like are controlled, molybdenum disulfide nanocrystals which are well crystallized and have a few atomic layers (1-5 layers) are formed and can be well dispersed in a nonpolar solvent or base oil, and stable lubricating oil is formed. According to the method, raw materials are cheap and easy to obtain, the reaction time is short, the yield is high, instruments and equipment are simple, operation is convenient, safe and reliable, process repeatability is good, product quality is stable, and the method is suitable for industrial enlarged production.

The present invention discloses a preparation method and application of a fatty dioic acid derivative. The method is as below: first reacting long-chain fatty dioic acid with thionyl chloride to obtain acyl chloride; reacting acyl chloride with t-butanol and removing chlorine group to obtain long-chain tert-butyl fatty dioic acid; then reacting the tert-butyl fatty dioic acid with N-hydroxy succinimide to obtain long-chain fatty dioic acid succinimidyl tert-butyl ester; reacting long-chain fatty dioic acid succinimidyl tert-butyl ester with L- glutamic acid-1-t-butyl ester to obtain tert-butyl long-chain aliphatic diacyl-L-Glu-OtBu; then reacting tert-butyl long-chain aliphatic diacyl-L-Glu-OtBu with N-hydroxysuccinimide to obtain tert-butyl long-chain aliphatic diacyl-L-Glu(OSu)-OtBu; and finally, removing the fatty dioic acid derivative in the tert-butyl long-chain aliphatic diacyl-L-Glu(OSu)-OtBu to obtain long-chain fatty dioic acid derivative. The method has the advantages of simple route operation, controllable quality, suitability for industrial scale production, low cost, simple purification, and is applicable to the preparation of high purity insulin analogues.

The invention relates to a ruthenium carbene complex, a preparation method and an application thereof. The chemical formula of the ruthenium carbene complex is shown as formula (I), wherein X is selected from trifluoromethyl, nitryl, dimethylamino or cyanogroup. In a preparation process, firstly, chloromethyl benzene ligand reacts with zinc alkyls so as to synthesize a chloromethyl benzene-zinc alkyls compound, and then the chloromethyl benzene-zinc alkyls compound reacts with tris (triphenylphosphine) ruthenium chloride and tricyclohexylphosphine in turn so as to acquire a catalyst precursor, and lastly, the catalyst precursor and N-heterocyclic carbene are subjected to ligand replacement. The prepared ruthenium carbene complex is used as a catalyst for catalyzing the olefin metathesis. Compared with the prior art, the ruthenium carbene complex provided by the invention has the advantages of convenience in preparation, property stability and capability of effectively catalyzing the olefin metathesis. The preparation method is characterized by simple operation, technology stability, controllability, environment-friendly effect, high yield, suitability for industrial amplification production and wide application prospect.

The invention relates to a method for synthesizing organic compounds, in particular to a process method for synthesizing 4-site heteroatom-substituted cyclohexenyl halide. The method comprises the following steps of: performing refluxing reaction on 4-site heteroatom-substituted cyclohexanone (1) and 1 to 50 equivalents of anhydrous hydrazine or hydrazine hydrate in a solvent at the temperature of -20 DEG C; filtering or spin-drying the solvent to obtain corresponding hydrazone; reacting the hydrazone with a CuX2 / alkali mixture in an alcohol solvent at the temperature of between -20 and 40 DEG C; adding aqueous alkali and a solvent after the reaction; performing separation to obtain mixed solution; adding organic alkali and performing the refluxing reaction; adding 1N acid to remove excessive alkali; adding saturated NaHSO3 to react; and removing the solvent to obtain the 4-site heteroatom-substituted cyclohexenyl halide (3). The method has the advantages of original and simple synthesis process and mild process condition, is easy and convenient to operate, avoids super-low temperature reaction and column chromatography purification involved in literatures, and is suitable for industrial scale-up production.

The present invention provides one kind of slow released dry azithromycin suspension and its preparation process. The medicine of the present invention has slow released azithromycin microsphere prepared through spray drying process, and capsule wall material for coating azithromycin medicine made of viscous medicinal polymer material or insoluble medicine polymer material, such as acrylic polymer, gelatin, Arabic gum, carboxymethyl cellulose salt, etc. and preferably of acrylic polymer. The slow released dry azithromycin suspension has improved administration compliance and convenience, and high bioavailability.

The invention belongs to the technical field of medicine, and relates to a preparation method of iron-protein succinylate with a high iron content. The preparation method comprises the following steps: (1) acylation: adding succinic anhydride into a casein solution to carry out reactions, continuously adding a sodium hydroxide solution into the reaction system to keep the pH value in a range of 6 to 9, after the reaction, adding acid into the reaction liquid to adjust the pH value to a range of 1 to 4, and filtering to obtain precipitate; (2) iron loading: dispersing the obtained precipitate into water, adding a proper amount of sodium hydroxide solution, stirring to dissolve the precipitate, then adding a ferric trichloride solution containing sodium bicarbonate into the obtained protein succinylate solution, adding a sodium hydroxide solution simultaneously to maintain the pH value of the reaction liquid in a range of 6 to 9, after the reaction filtering to remove the insoluble substances so as to obtain a iron-protein succinylate solution; refining the solution to remove the insoluble substance, adding acid to generate precipitate, filtering to obtain the precipitate, washing the precipitate by water, and finally drying the precipitate. In the recent literature, the reported iron content of iron-protein succinylate is in a range of 4.5 to 10%, while the iron content of iron-protein succinylate prepared by the provided method is as high as 15%. Moreover, the provided preparation method has the advantages of simple technology, good product solubility, and stable product quality.

The invention discloses a preparation method of a buckwheat dietary fiber chewable tablet. The preparation method comprises the steps of 1) preparing a main ingredient: buckwheat dietary fiber granules as well as accessories: water-soluble dietary fiber, a filler, a sweetening agent and a sour agent, and completely and uniformly mixing to obtain a mixture; 2) adding a wetting agent to the mixture, sieving and granulating for the first time after preparing a soft material, drying until water content of the granules is less than 5%, and sieving and straightening granules for the second time; and 3) adding 0.5-1.0% of magnesium stearate in terms of mass of the granules obtained from the step 2), completely and uniformly mixing, tabletting and sterilizing to obtain the buckwheat dietary fiber chewable tablet. The preparation method is simple, easy and convenient to operate, environment-friendly, and applicable to industrial amplification production. The prepared buckwheat dietary fiber chewable tablet is complete and clean in appearance, uniform in color, delicate in taste, and moderately sour and sweet; and depending on regulation of Chinese Pharmacopoeia, both heavy metal content and microbiological indicator of the buckwheat dietary fiber chewable tablet are tested to be consistent with requirement.

The invention discloses a humic acid bagging-free film bag and a preparing method and use method thereof. The preparing method includes: dissolving SiO2 in an acetic acid aqueous solution, adding chitosan, fully dissolving the chitosan, adding glycerinum, and acquiring a chitosan complex mother liquor; acquiring a potassium humate solution, and dissolving a certain amount of bottle gourd pakistan rubber in the potassium humate solution; mixing the chitosan complex mother liquor and the potassium humate solution with the bottle gourd pakistan rubber with stirring, evenly stirring the two solutions so as to acquire a novel high efficiency multifunctional humic acid bagging-free film bag mother solution which has an anti-freezing function, an antibacterial function, and an anti-pest function, and can provide nutriment matters, using water to dilute the mother solution, and directly spraying surfaces of fruits with the diluted mother solution to form films. The humic acid bagging-free film bag is non-toxic, is harmless, is easy to use, can avoid plastic pollution and complex operations due to the conventional bags, can allow the fruits to resist cold weather, bacteria, and pests, can provide desired nutriment matters for the fruits during a growth development process, and can effectively improve the quality of the fruits.