Slow released dry azithromycin suspension and its prepn

A technology of azithromycin and dry suspension, which is applied in the field of medicine to achieve the effects of reducing the generation of drug-resistant strains, low production costs, and high bioavailability

Inactive Publication Date: 2007-01-03
漆新国 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] When azithromycin is taken orally, it often causes side effects such as abdominal pain, nausea, and diarrhea

Method used

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  • Slow released dry azithromycin suspension and its prepn

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Experimental program
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Effect test

Embodiment 1

[0023] The preparation process has the following steps:

[0024] ①Crush the azithromycin in the prescription and pass it through a 120-mesh sieve for use. ②Use 0.5% ammonia solution as solvent to prepare 0.6% acrylic resin No. II solution; ③Add the prescription amount of azithromycin obtained in step ① to the solution obtained in step ② and stir to prepare a suspension; ④ Add a prescription amount of talc to the suspension obtained in step ③ and stir evenly; ⑤ spray-dry the material obtained in step ④ with an inlet temperature of 160-180°C and an outlet temperature of about 90°C to prepare azithromycin sustained-release microspheres; ⑥Determine the content of the microspheres, and after calculation, add the corresponding excipients such as diluting deodorant and suspension according to the proportion, and then granulate.

Embodiment 2

[0027] The preparation process has the following steps:

[0028] ①Crush the azithromycin in the prescription and pass it through a 120-mesh sieve for use. ②Prepare an aqueous solution containing 3% gelatin and 0.5% sodium carboxymethylcellulose; ③Add the prescription amount of azithromycin obtained in step ① to the solution obtained in step ② and stir to make a suspension; ④in step ③ Add the prescription amount of talc to the obtained suspension and stir evenly; ⑤Spray-dry the material obtained in step ④, make the azithromycin sustained-release microspheres at an inlet temperature of 160-180℃ and an outlet temperature of about 90℃; ⑥this The content of the microspheres is determined, and after calculation, the corresponding auxiliary materials such as diluting deodorant and suspension are added in proportion to granulate, and then it is obtained.

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Abstract

The present invention provides one kind of slow released dry azithromycin suspension and its preparation process. The medicine of the present invention has slow released azithromycin microsphere prepared through spray drying process, and capsule wall material for coating azithromycin medicine made of viscous medicinal polymer material or insoluble medicine polymer material, such as acrylic polymer, gelatin, Arabic gum, carboxymethyl cellulose salt, etc. and preferably of acrylic polymer. The slow released dry azithromycin suspension has improved administration compliance and convenience, and high bioavailability.

Description

Technical field [0001] The invention relates to an azithromycin sustained-release dry suspension and a preparation method thereof, and belongs to the technical field of medicine. Background technique [0002] The chemical name of Azithromycin is: (2R, 3S, 4R, 5R, 8R, 10R, 11R, 12S, 13S, 14R)-13-[(2,6-Dideoxy-3-C-methyl-3-O- Methyl-α-L-nucleo-hexapyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl- 11-[[3,4,6-Trideoxy-3(dimethylamino)-β-D-wood-hexapyranosyl]oxy]-1-oxa-6-azacyclopentadecane-15 -ketone. [0003] Its structural formula is: [0004] [0005] Molecular formula: C 38 H 72 N 2 O 12 [0006] Molecular weight: 749.00 [0007] The research and development of azithromycin began with the discovery of erythromycin in the early 1950s, followed by 16-membered ring macrolides such as kitasamycin, and later it was a 14-membered ring with erythromycin and gastric acid. Roxithromycin and clarithromycin, which are called new macrolides, have improved stability, i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/7052A61K47/38A61P31/04
Inventor 唐星赵少春漆新国
Owner 漆新国
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