Medical hemostatic polysaccharide starch microsphere and preparation method thereof

A technology of starch microspheres and polysaccharides, applied in the field of medicine and chemical industry, can solve the problems of inability to achieve hemostatic effect, poor adhesion, slow water absorption, etc.

Active Publication Date: 2015-01-28
SHIJIAZHUANG YISHENGTANG MEDICAL SUPPLIES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the microporous starch hemostatic material on the market is Alistair hemostatic powder from the United States, which is cross-linked with starch and epichlorohydrin to form ethyl propyl alcohol to make hemostatic particles. The product has good biocompatibility and has certain The hemostatic effect is good, but the water absorption is slow and the adhesion is poor. For a large area of ​​bleeding, it still cannot achieve a good hemostatic effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] The following method is used to prepare medical hemostatic polysaccharide starch microspheres:

[0062] (1) Pretreatment of starch: Weigh 200g of food-grade potato starch (raw flour) and add 2L of water to mix, heat in a water bath at 70°C until gelatinization, add 80mL of 32% hydrochloric acid solution to the starch solution for 5 minutes of gelatinization, and acidify After reacting for 5 hours, the temperature was lowered after the reaction was completed, and after standing for stratification, the precipitate was washed 3 times with water, centrifuged and dried to obtain acid-thinned starch;

[0063] (2) Alkalized starch: Weigh 100g of acid-thinned starch and add it to 1000ml of 10% sodium hydroxide solution to dissolve until clear;

[0064] (3) Emulsification reaction: adjust the temperature of the reactor to 45°C, add 20g of Span80 to 4L of liquid paraffin to disperse, and after the temperature of the reactor is constant, add the starch sodium salt solution to the ...

Embodiment 2

[0069] The following method is used to prepare medical hemostatic polysaccharide starch microspheres:

[0070] (1) Pretreatment of starch: Weigh 200g of food-grade potato starch (raw flour) and add 1L of purified water, heat in a water bath at 75°C until gelatinization, add 80ml of 18% hydrochloric acid solution to the gelatinization starch solution for 1min, and acidify After 8 hours, the temperature was lowered after the reaction was completed, and the precipitate was washed 3 times with water after standing for stratification, and then centrifuged and dried to obtain acid-thinned starch;

[0071] (2) Alkalized starch: Weigh 100g of acid-thinned starch and add it to 800ml of 5% sodium hydroxide solution to dissolve until clear;

[0072] (3) Emulsification reaction: Adjust the temperature of the reactor to 40°C, add 20g of Span80 to 2L of liquid paraffin to disperse, and after the temperature of the reactor is constant, add the starch sodium salt solution to the liquid paraff...

Embodiment 3

[0077] The following method is used to prepare medical hemostatic polysaccharide starch microspheres:

[0078] (1) Pretreatment starch: Weigh 200g of food-grade potato starch (raw flour) and add 4L of purified water, heat in a water bath at 65°C until gelatinization, add 80ml of 26% hydrochloric acid solution into the starch solution for 10 minutes of gelatinization, acid hydrolysis reaction After 1h, the temperature was lowered after the reaction was completed, and the precipitate was washed 3 times with water after standing for stratification, and then centrifuged and dried to obtain acid-thinned starch;

[0079] (2) Alkalized starch: Weigh 100g of acid-thinned starch and add it to 1200ml of 20% sodium hydroxide solution to dissolve until clear;

[0080] (3) Emulsification reaction: adjust the temperature of the reactor to 60°C, add 25g of Span60 to 5L of liquid paraffin to disperse, after the temperature of the reactor is constant, add the starch sodium salt solution to the...

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Abstract

The invention relates to a preparation method and a refining method of medical hemostatic polysaccharide starch. With pretreated potato starch as a raw material and epichlorohydrin as a crosslinking agent, a microsphere adopting a three-dimensional network structure is synthesized by an emulsifying and crosslinking technology. The medical hemostatic polysaccharide starch is high in biocompatibility; the medical hemostatic polysaccharide starch is full with wrinkles on the surface, so that the particle surface area is increased, the water absorbing rate is significantly improved and the hemostatic time is greatly reduced; the medical hemostatic polysaccharide starch is especially applicable to large-area blood seepage, deep bleeding, and bleeding at a part difficult to reach by operative procedures.

Description

technical field [0001] The invention belongs to the field of medicine and chemical industry, and in particular relates to a medical hemostatic polysaccharide starch microsphere and a preparation method thereof. Background technique [0002] Absorbable hemostatic materials can directly reduce blood loss in the body to effectively maintain blood volume, avoid adverse reactions caused by systemic use of coagulation drugs, reduce blood transfusion and operation time; and indirectly shorten the hospital stay of patients to reduce costs. At present, a variety of hemostatic materials with different compositions and mechanisms have been developed in the market, and these materials are used in different occasions due to their respective characteristics. At present, the commonly used hemostatic materials include traditional alginate, more distant and newly emerging collagen complexes, fibrin products, chitosan, etc. However, some of the above-mentioned many hemostatic materials are o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J9/28C08J3/24C08L3/02C08B30/18A61K31/715
Inventor 李素哲胡荣现高攀赵彦斌刘媞
Owner SHIJIAZHUANG YISHENGTANG MEDICAL SUPPLIES
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