Valnemulin hydrochloride self-emulsified oral nano emulsion for veterinary use and preparation method thereof

A self-emulsification technology of warnemulin hydrochloride, which is applied in the direction of emulsion delivery, oil/fat/wax non-active ingredients, antibacterial drugs, etc., can solve the unavoidable palatability of warnemulin, drug overdose or deficiency , lower content of warnimulin, etc., to achieve the effect of reducing individual differences in administration, improving oral bioavailability, and reducing oral irritation
CN102415996BActive Publication Date: 2013-06-05QILU ANIMAL HEALTH PROD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
QILU ANIMAL HEALTH PROD
Publication Date
2013-06-05

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Abstract

The invention discloses valnemulin hydrochloride self-emulsified oral nano emulsion for veterinary use and a preparation method thereof. The valnemulin hydrochloride self-emulsified oral nano emulsion for veterinary use comprises the following components: valnemulin hydrochloride, oil, surfactant, preservative, antioxygen and auxiliary surfactant. After disintegrating in water and being stirred slightly or being taken orally and moving with intestine movement, the self-emulsified emulsion can spontaneously form emulsion with emulsion droplet size of 10 to 100 nanometers; the drawbacks of decomposition of valnemulin during long standing and content reduction of the valnemulin or valnemulin hydrochloride nano emulsion prepared in the prior art are overcome and the content stability of the product is increased; the palatability of the valnemulin product is improved; and the preparation process is simple, and the valnemulin hydrochloride self-emulsified oral nano emulsion is suitable to be produced in large scale by veterinary medicine enterprises.
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Description

technical field

[0001] The invention relates to a self-emulsifying oral nanoemulsion preparation of veterinary warnemulin hydrochloride and a preparation method thereof, belonging to the technical field of veterinary medicines. Background technique

[0002] Vernimulin is a new generation of pleuromutilin semi-synthetic animal-specific antibiotics. It is unanimously recognized as the first choice drug for the treatment of animal mycoplasma disease, mainly used for the prevention and treatment of mycoplasma disease and Gram disease in pigs, cattle, sheep and poultry. positive bacterial infection. Its hydrochloride is commonly used clinically, and it is rapidly absorbed after oral administration, and its bioavailability is close to 100%. The mechanism of action is to inhibit bacterial protein synthesis at the ribosome level, and at high concentrations, it also inhibits RNA synthesis.

[0003] Wonimulin tastes bitter, extremely irritating, insoluble and unstable in water, and ...

Claims

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