Valnemulin hydrochloride self-emulsified oral nano emulsion for veterinary use and preparation method thereof
A self-emulsification technology of warnemulin hydrochloride, which is applied in the direction of emulsion delivery, oil/fat/wax non-active ingredients, antibacterial drugs, etc., can solve the unavoidable palatability of warnemulin, drug overdose or deficiency , lower content of warnimulin, etc., to achieve the effect of reducing individual differences in administration, improving oral bioavailability, and reducing oral irritation
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0024] A veterinary self-emulsifying oral nanoemulsion preparation of warnemulin hydrochloride, the components are as follows:
[0025]
[0026] The preparation method of the above-mentioned warnimulin hydrochloride self-emulsifying oral nanoemulsion preparation for animals comprises the following steps:
[0027] (1) First mix and stir 13g oil, 35g surfactant and 95ml co-surfactant evenly, then add 1g antioxidant and 1g preservative, stir until completely dissolved to obtain a clear oily liquid;
[0028] (2) Add warnemulin hydrochloride to the clear oily liquid prepared in step (1), set the volume to 100ml with co-surfactant, and stir at 40-60°C until completely dissolved to obtain the veterinary hydrochloride Nimulin self-emulsifying oral nanoemulsion formulation.
[0029] Physical and chemical properties:
[0030] 1. Particle size measurement:
[0031] Example 1 Determination of self-emulsifying ability: Take 50 μl of vonemulin hydrochloride self-emulsifying agent and ...
Embodiment 2
[0051] A veterinary self-emulsifying oral nanoemulsion preparation of warnemulin hydrochloride, the components are as follows:
[0052]
[0053] The preparation method is the same as in Example 1.
[0054]6-month acceleration and 12-month long-term stability test conditions are as described in Example 1. After the test, the preparation still remains clear and transparent, without delamination and crystallization. After 6 months of acceleration, the content of warnemulin hydrochloride is 10.87 wt%, after the 12-month long-term stability test, the content of warnemulin hydrochloride was 10.98 wt%, and the results showed that the content of warnemulin hydrochloride did not significantly decrease, and the product had good stability. Take 50 μl of the varnemulin self-emulsifying nanoemulsion described in Example 2 and add it to a 100ml volumetric flask, dilute to the mark with distilled water, shake gently, and still form a clear microemulsion, which is measured by a particle si...
Embodiment 3
[0056] A veterinary self-emulsifying oral nanoemulsion preparation of warnemulin hydrochloride, the components are as follows:
[0057]
[0058]
[0059] The preparation method is the same as in Example 1.
[0060] 6-month accelerated and 12-month long-term stability test conditions are as described in Example 1. After the test, the preparation still remains clear and transparent without delamination and crystallization. wt%, after the 12-month long-term stability test, the content of warnemulin hydrochloride was 11.96 wt%, and the results showed that the content of warnemulin hydrochloride did not significantly decrease, and the product had good stability. Take 50 μl of the varnemulin self-emulsifying nanoemulsion described in Example 2 and add it to a 100ml volumetric flask, dilute to the mark with distilled water, shake gently, and still form a clear microemulsion, which is measured by a particle size analyzer. The distribution is between 10 and 100nm, and the averag...
PUM
Property | Measurement | Unit |
---|---|---|
particle diameter | aaaaa | aaaaa |
particle size | aaaaa | aaaaa |
particle size | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com