18 results about "Time to hemostasis" patented technology

The utility model belongs to the technical field of tourniquets, and particularly relates to a spinning tourniquet which comprises a self-adhesive tape, a buckle shaped like a Chinese character'ri 'is fixedly connected to one end of the self-adhesive tape, a screwing mechanism is arranged on the self-adhesive tape, and the screwing mechanism is close to the buckle shaped like the Chinese character'ri'. The screwing mechanism comprises a pressurizing assembly arranged on the self-adhesive tape, the pressurizing assembly is in transmission connection with a screwing assembly, a self-locking structure is arranged in the screwing assembly, a timer is arranged on the screwing assembly, and a marking pen is detachably connected to the screwing assembly. The spinning tourniquet is provided with the timer and the marking pen, a user can conveniently record the hemostasis time, and the situation that the hemostasis effect is poor due to the short hemostasis time or the limbs are damaged or necrotic due to the long hemostasis time is avoided.

The utility model relates to the technical field of tourniquets, and discloses an emergency treatment tourniquet which comprises a transparent hemostasis plate, a fixing block is fixedly installed at the bottom of the transparent hemostasis plate, a rotating rod is rotatably installed in the fixing block, a threaded groove is formed in the bottom of the rotating rod, a lead screw is rotatably installed in the threaded groove, and the lead screw penetrates through the fixing block and extends to the bottom. By rotating the rotating rod, the lead screw moves downwards in the threaded groove through threaded connection, at the moment, the fixing rod slides in the sliding groove, the hemostasis compression plate is driven to stably and downwards apply pressure to a bleeding wound, and the pressure applying state of the hemostasis compression plate is conveniently observed through the transparent hemostasis plate; the screw rod can slowly drive the hemostasis compression plate to apply appropriate compression force to a wound for hemostasis, hemostasis is set in a timing mode through the display screen, an alarm is given out through the loudspeaker when the hemostasis time is up, and therefore hemostasis compression of the wound can be relieved in time, and the situation that local tissue is damaged due to the fact that hemostasis compression of the wound is not relieved in time is solved.

The invention aims to provide an automatic contraction tourniquet, which comprises a power supply (16), fixed braids (2, 10) and an elastic device, and the elastic device is powered by the power supply (16) to tighten and loosen the fixed braids (2, 10). The automatic contraction tourniquet disclosed by the invention has the following excellent effects that the automatic contraction tourniquet has a better contraction effect through the design of an electric structure; use is convenient and operation is simple; the display screen is arranged, so that an operator or a patient can be prompted of hemostasis time in real time, and the use safety and convenience are improved.

The invention relates to the technical field of medical gel, and discloses hemostatic gel and a preparation method thereof, the hemostatic gel comprises the following components by weight: 6-10 parts of sodium alginate, 4-7 parts of quaternary ammonium salt modified silane, 2-3 parts of glutaraldehyde, and 3-4 parts of water. Sodium alginate is used as a base material, carboxyl in the molecular structure of the sodium alginate can be subjected to a cross-linking reaction with calcium ions in blood, a gelatinous network structure is rapidly formed, red blood cells and blood platelets are effectively wrapped, and the blood coagulation process is accelerated; meanwhile, the introduction of quaternary ammonium salt modified silane can enhance the adhesiveness of the gel and wound tissues, the gel is tightly attached to the wound surface, blood exudation is reduced, the hemostasis time is remarkably shortened, and the gel is particularly suitable for wound first-aid scenes.

The utility model discloses a quick tightening tourniquet, which relates to the technical field of medical instruments and comprises a tourniquet mechanism, a ratchet tightening mechanism is arranged on the surface of the tourniquet mechanism, a timing mechanism is arranged on the surface of the ratchet tightening mechanism, and a buckle mechanism is arranged on the outer wall of the tourniquet mechanism. According to the tourniquet, the hemostatic efficiency can be improved through the buckle mechanism, a patient can conveniently and rapidly fix the tourniquet to the injured part of the patient, the hemostatic time can be effectively shortened, and when the fixing band needs to be fixed to the injured part of the patient, only the length of the tourniquet needs to be adjusted according to the injured part of the patient, and the tourniquet can be fixed conveniently. Then the clamping block is inserted into the clamping groove, meanwhile, the fixing block on the surface of the clamping hole is clamped with the clamping hole to complete closing of the tourniquet, then the device can be fixed to the injured part of a patient, operation of the device is simpler and more convenient, many tedious steps can be omitted (an old-fashioned penetrating structure is changed into a buckle), and self rescue of the injured is better facilitated.

The invention discloses an acute gastrorrhagia hemostatic agent based on a gardenia carbon nano composite material and a preparation method of the acute gastrorrhagia hemostatic agent, and belongs to the technical field of biological medicines. According to the preparation method disclosed by the invention, the gardenia carbon nano composite material is prepared through nanocrystallization transformation, and the average particle size is 2.35 nm + / -0.56 nm. Mouse tail cutting hemostasis and capillary experiments prove that the gardenia charcoal nano composite material has the effects of promoting hemostasis and blood coagulation, and the hemostasis time and the blood coagulation time can be remarkably shortened; through construction of a rat blood-heat gastrorrhagia model, it is verified that the gardenia charcoal nano composite material has a remarkable hemostatic effect; and zebra fish verifies that the gardenia carbon nano composite material can protect gastrointestinal mucosa from being damaged, specifically, the area of a small intestinal cavity is reduced, and the number of neutrophils in the intestinal tract is reduced. The gardenia carbon nano composite material provided by the invention can be used for preparing a medicine for promoting blood coagulation and / or hemostasis, a hemostatic for acute gastrorrhagia and a medicine for relieving gastrointestinal mucosal injury.

This invention relates to a two-component cross-linked oxidized nanocellulose spray hemostatic gel, its preparation method, and its application, belonging to the field of biomedical materials. Addressing the problems of weak adhesion, insufficient mechanical properties, and biocompatibility risks in existing hemostatic materials, this invention introduces aldehyde groups using sodium periodate to prepare an adhesive component (TOCN-CHO), and simultaneously modifies the carboxyl groups of TOCN with lysine to create a cross-linking component (TOCN-Lys). After the two components are sprayed and mixed, the aldehyde groups of TOCN-CHO bind to the amino groups on the tissue surface to achieve wound sealing. Simultaneously, the amino groups of TOCN-Lys form a Schiff base cross-linking network in situ with the aldehyde groups of TOCN-CHO, enhancing mechanical strength while eliminating aldehyde toxicity. The gel retains shear-thinning properties and can be sprayed. Animal experiments show that the hemostasis time is reduced to 28 seconds. It also exhibits biodegradability and renewability, effectively solving the problem of synergistic optimization of adhesion, mechanical strength, and biocompatibility, making it suitable for emergency hemostasis and surgical scenarios.

This invention provides a chitosan hemostatic material for rapid arterial hemostasis, its preparation process, and its applications, relating to the field of medical technology. The chitosan hemostatic material prepared by this invention can significantly shorten hemostasis time, maintain stable adhesion to the wound surface even under the impact of arterial blood flow, and is not easily detached, exhibiting strong wet adhesion and erosion resistance. The chitosan hemostatic material prepared by this invention not only improves the mechanical strength of the material but also provides more bioactive sites, activating intrinsic coagulation pathways and platelet aggregation, thereby improving hemostasis efficiency and showing significant advantages in emergency applications for arterial bleeding. The chitosan hemostatic material prepared by this invention combines rapid coagulation and stable hemostasis, and has good biocompatibility, controllable degradation, reduced inflammatory response, and high safety. The porous structure of the chitosan hemostatic material prepared by this invention is beneficial for tissue repair, does not adhere to other tissues, promotes healing, and has promising application prospects.

The present application relates to the field of clinical medical technology, in particular to an intelligent hemostasis system and method; the present application collects blood pressure, heart rate, hemostasis pressure, patient body data and patient wound data through a hemostasis device, and constructs a hemostasis time-pressure prediction model through a differential evolution algorithm and a WaveNet model, so as to realize prediction of a relationship curve between hemostasis pressure and hemostasis time; through the relationship curve, the hemostasis device can adjust the pressure applied by the hemostasis device as needed, so as to avoid problems such as excessive hemostasis pressure of a tourniquet, excessive hemostasis time leading to necrosis of a limb or a local part under pressure, and poor hemostasis caused by too small pressure in a war injury treatment process.

The utility model discloses an automatic radial artery compression hemostat, which belongs to the technical field of hemostats and comprises a controller and a humidity sensor, the controller is fixedly mounted on a first curved plate, the humidity sensor is mounted inside a compression cushion, a hemostasis application pad is mounted at the bottom of the compression cushion, and the humidity sensor is used for detecting the humidity value of the hemostasis application pad. An air bag is installed at the top of the pressing cushion and communicated with an air pump, and the air pump inflates the air bag to extrude the pressing cushion to press the puncture position. According to the utility model, the humidity sensor detects the humidity value on the hemostasis application pad at set intervals and uploads the humidity value to the controller, and the controller receives data and compares whether the data is consistent with the humidity value received last time so as to judge whether the puncture position is errhysis, so that the compression soft pad is controlled to continuously apply pressure to the puncture position or not; therefore, the problem that postoperative recovery of a patient is affected due to the fact that compression hemostasis time is difficult to guarantee is solved.

The invention relates to hemostatic sponge with antibacterial osteogenesis performance as well as a preparation method and application of the hemostatic sponge. The method comprises the following steps: uniformly mixing metal compound powder and bioactive ceramic powder, tabletting, calcining, grinding and sieving to obtain modified bioactive ceramic powder; uniformly mixing the modified bioactive ceramic powder with a water-based polymer solution with biocompatibility, and then adding a cross-linking agent for cross-linking to obtain mixed gel; and freezing and freeze-drying to obtain the hemostatic sponge. The hemostatic sponge prepared by the invention has a porous structure, a shape memory function, excellent antibacterial property, efficient coagulation property and bone repair promotion capability, has degradability and good biocompatibility, can synchronously solve the problems of bleeding, infection and alveolar bone absorption after tooth extraction, and has a good application prospect when being used as a tooth extraction wound repair material. The material can reduce blood loss, shorten hemostasis time and promote alveolar bone regeneration, and is a biomedical material with great clinical value.

The invention relates to the technical field of medical auxiliary equipment, in particular to a tourniquet which comprises a pressing part, the two sides of the pressing part extend upwards to form two side arms, and at least one part of each side arm is made of an elastic material. The tourniquet accurately guides pressure to a puncture point, the direction is vertical, the force is concentrated, a puncture opening in the blood vessel wall can be effectively pressed, and subcutaneous extravasated blood is fundamentally prevented; once the tourniquet is bound, continuous and stable pressing can be provided until the hemostasis time is reached, a user can freely move, and the blood sampling experience is greatly improved.

The invention provides an entanglement-locked expansion protein-based tissue adhesive as well as a preparation method and application thereof. According to the preparation method, a protein structure is destroyed by utilizing a disulfide bond reducing agent to obtain expanded protein with exposed hydrophobic groups, and then the expanded protein is subjected to strong interaction (electrostatic interaction and hydrogen bond) through polyelectrolyte and the expanded protein; the lock unfolds the exposed hydrophobic groups on the surface of the protein to stably expose the hydrophobic groups and lock chain entanglement therebetween. The entangled-locked expanded protein-based tissue adhesive has a stably exposed hydrophobic group, and has the advantages of strong hydrophobic property, strong adhesive force, stable adhesive property, excellent body performance (high storage modulus), good biocompatibility and good degradability. In addition, when the entangled-locked expansion protein-based tissue adhesive is applied to bleeding wounds, the hemostatic effect is achieved, the hemostatic time is remarkably shortened, the wound blood loss amount is remarkably reduced, and the excellent hemostatic plugging effect is achieved.

This utility model discloses an arterial hemostat, which includes a pressure plate, a fixing component, a hemostatic component, and a coagulation-promoting layer. The pressure plate and the fixing component form a receiving space. The hemostatic component is mounted on the pressure plate, and a coagulation-promoting layer is provided at one end of the hemostatic component facing the receiving space. By adjusting the hemostatic component, the coagulation-promoting layer is brought closer to the patient's puncture site to apply pressure and stop bleeding at the puncture site. This utility model solves the problem of long compression hemostasis time after arterial puncture by providing a coagulation-promoting layer at the adjustment part.

This invention relates to the field of medical gel technology and discloses a hemostatic gel and its preparation method, comprising the following components by weight: 6-10 parts sodium alginate, 4-7 parts quaternary ammonium salt-modified silane, 2-3 parts glutaraldehyde, and 3-4 parts water. Using sodium alginate as a base material, the carboxyl groups in its molecular structure can undergo a cross-linking reaction with calcium ions in blood, rapidly forming a gel-like network structure that effectively encapsulates red blood cells and platelets, accelerating the coagulation process. Simultaneously, the introduction of quaternary ammonium salt-modified silane enhances the adhesion between the gel and wound tissue, tightly adhering to the wound surface, reducing blood exudation, and significantly shortening hemostasis time, making it particularly suitable for trauma emergency scenarios.

The invention belongs to the technical field of medical hemostatic materials, and particularly relates to an asymmetric hemostatic patch with blind holes and a preparation method and application thereof. The preparation method of the hemostatic patch comprises the following steps: mixing a hydrogel pre-polymerization solution containing a hydrogel monomer, an emulsifier, a first photoinitiator, a first cross-linking agent and deionized water and an oil gel pre-polymerization solution containing an oil gel monomer, the first photoinitiator and a second cross-linking agent according to a mass ratio of (1-4): 1. And injecting the mixture into a mold, and obtaining the asymmetric hemostatic patch with the blind hole through hydrophilic and hydrophobic interface induction and ultraviolet polymerization. The mold is composed of a hydrophobic substrate, a hydrophilic substrate and a hydrophilic column. According to the asymmetric hemostatic patch with the blind holes, the adhesion performance can be remarkably improved through efficient removal of interface water, so that the hemostatic time and the bleeding amount of damaged tissues are effectively reduced, and the efficient hemostatic effect is achieved.

The hydrogel takes glycyrrhizic acid and pterostilbene as main components, and a three-dimensional network structure is formed by self-assembly through an aqueous solution method by utilizing hydrogen bonds and pi-pi stacking action between the glycyrrhizic acid and the pterostilbene. The preparation method is simple and convenient in process, free of additional cross-linking agents or organic solvents and suitable for large-scale production. In addition, the hydrogel is constructed by means of natural active components, shows excellent biodegradability and extremely low toxicity, and avoids the common problem of degradation lag or in-vivo toxic and side reaction of a synthetic polymer alleviator. The hydrogel shows good flexibility, wet tissue adhesion and injectability, and can quickly stop bleeding and firmly cover a wound surface. The hemostasis time can be obviously shortened and the blood loss amount can be reduced in a liver incision model; a cell viability test also proves that the hydrogel has excellent biocompatibility; in addition, the composition also has antibacterial and antioxidant activity, and is helpful for inhibiting inflammatory response and promoting tissue healing. The hydrogel is suitable for various medical scenes such as intraoperative hemostasis, trauma treatment and chronic wound dressing, and has a wide application prospect.

The invention is applicable to the technical field of biomedical materials, and provides composite hydrogel based on an extracellular matrix and an MXene material as well as a preparation method and application of the composite hydrogel. The composite hydrogel is formed by compounding a human extracellular matrix (hECM) pre-gel solution and a Ti3C2Tx MXene nanosheet dispersion liquid and then carrying out self-assembly gelation, and the excellent rheological property and temperature response type in-situ gelation and injection characteristics of the extracellular matrix (ECM) and the photo-thermal antibacterial and hemostatic enhancement functions of the MXene are integrated. The hemostasis time can be remarkably shortened, the bleeding amount can be reduced, inflammation can be effectively controlled, wound closure is promoted, granulation tissue formation is accelerated, and tissue regeneration is stimulated; tissue residues generated in a clinical operation are converted into functional biological materials, so that resource reutilization is realized; a new scheme is provided for complex wound management, and a new thought is provided for material design in the field of regenerative medicine.