Preparation methods of poly-l-lactide particles and injectable soft tissue filler

A poly-L-lactic acid and soft tissue technology, applied in the field of medicine, can solve the problems of complex poly-L-lactic acid particle process, difficult product purification, unfavorable scale-up production, etc., and achieves excellent water-phase easy dispersibility, low production cost, and long retention period. Effect

Inactive Publication Date: 2020-02-28
南京思元医疗技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] An object of the present invention is to solve the technical problems that a large amount of emulsifier or dispersant is usually required to be introduced in the preparation of poly-L-lactic acid microparticles in the prior art, resulting in difficult product purification and poor biocompatibility
[0006] A further object of the present invention is to solve the technical problems that in the prior art when preparing poly-L-lactic acid microparticles, the process is too complicated, the cost is high, and it is not conducive to scale-up production

Method used

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  • Preparation methods of poly-l-lactide particles and injectable soft tissue filler
  • Preparation methods of poly-l-lactide particles and injectable soft tissue filler
  • Preparation methods of poly-l-lactide particles and injectable soft tissue filler

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preparation example Construction

[0049] figure 1 A schematic flow chart showing a method for preparing poly-L-lactic acid microparticles according to an embodiment of the present invention. Such as figure 1 Shown, this preparation method comprises:

[0050] Step 1, dissolving poly-L-lactic acid in a good solvent to obtain a poly-L-lactic acid solution;

[0051]Step 2, adding the poly-L-lactic acid solution into the reaction kettle, and applying an anti-solvent under the condition of stirring, so as to separate the poly-L-lactic acid particles from the reaction solution;

[0052] Step 3, filtering the reaction solution in which the poly-L-lactic acid microparticles are suspended, and purifying and drying to obtain the poly-L-lactic acid microparticles.

[0053] In step one, the molecular weight of poly-L-lactic acid can be 3KDa, 10KDa, 20KDa, 50KDa, 100KDa, 150KDa or 200KDa, or any other value in the range of 3-200KDa. The poly-L-lactic acid with this molecular weight can be purchased directly on the marke...

Embodiment 1

[0079] The embodiment of the present invention provides a preparation method of poly-L-lactic acid microparticles, the preparation method comprising the following steps:

[0080] 1) Weigh 20g of poly-L-lactic acid with a molecular weight of 20KDa, dissolve it in 1.2L of dichloromethane solvent, and configure it into a 0.016g / mL polylactic acid solution;

[0081] 2) Add the poly-L-lactic acid solution into the reaction kettle with magnetic stirring, and drop the ethanol anti-solvent into the reaction kettle with the speed of 100mL / min through the peristaltic pump under the magnetic stirring of 600rpm, and drop the total amount of the ethanol anti-solvent The volume is 6L. When the amount of ethanol added reaches a certain volume, poly-L-lactic acid particles will precipitate out in the reaction kettle;

[0082] 3) Pour the reaction solution in which poly-L-lactic acid particles are suspended into a 100-mesh stainless steel screen, and filter to obtain poly-L-lactic acid particl...

Embodiment 2

[0088] The embodiment of the present invention provides a preparation method of poly-L-lactic acid microparticles, the preparation method comprising the following steps:

[0089] 1) Weigh 50g of poly-L-lactic acid with a molecular weight of 70KDa, dissolve it in 1.5L of chloroform solvent, and configure it into a 0.033g / mL polylactic acid solution;

[0090] 2) Add the poly-L-lactic acid solution into the reaction kettle with magnetic stirring, and drop the ethanol anti-solvent in the reaction kettle with the speed of 50mL / min through the peristaltic pump under the magnetic stirring of 400rpm, and add the total amount of the ethanol anti-solvent dropwise. The volume is 3L. When the amount of ethanol added reaches a certain volume, poly-L-lactic acid particles will precipitate out in the reaction kettle;

[0091] 3) Pour the reaction solution in which poly-L-lactic acid particles are suspended into a 500-mesh stainless steel screen, and filter to obtain poly-L-lactic acid partic...

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Abstract

The invention provides a preparation method of poly-l-lactide particles and a preparation method of an injectable soft tissue filler. The preparation method of the poly-l-lactide particles includes the steps: first, dissolving poly-l-lactide in good solvents to obtain poly-l-lactide solution; second, adding the poly-l-lactide solution into a reactor and adding anti-solvents under the condition ofstirring to separate out the poly-l-lactide particles from reaction solution; third, filtering the reaction solution with suspending poly-l-lactide particles, purifying and drying the reaction solution to obtain the poly-l-lactide particles. The poly-l-lactide particles are prepared by a soap-free good solvent-anti-solvent precipitation method, addition of any emulsifiers and dispersing agents isomitted in the preparation process of the particles, a technological process is simple in operation, and the preparation method is low in production cost, high in production efficiency and suitable for industrial amplified production.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a preparation method of poly-L-lactic acid microparticles and a preparation method of an injectable soft tissue filler. Background technique [0002] With the development of the medical beauty industry, injection filling materials are getting more and more attention. By injecting filling materials, eyebrows can be raised, temples can be plumped, cheeks can be plumped, nasolabial folds can be improved, skin wrinkles at the corners of the mouth can be improved, jawline can be plumped, and chin contour lines can be tightened. And other beauty effects. At present, sodium hyaluronate (hyaluronic acid), the most commonly used injection filling material in the beauty industry, has a good filling effect, but due to the rapid degradation of hyaluronic acid, patients usually need repeated injections every 6 months or so. , and, for more serious facial depressions and deep wrinkles, the f...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/18A61L27/24A61L27/20A61L27/50
CPCA61L27/18A61L27/24A61L27/20A61L27/50A61L2400/06A61L2430/34C08L67/04C08L5/08C08L1/286
Inventor 薛姚栾婧
Owner 南京思元医疗技术有限公司
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