Preparation method of iron-protein succinylate with high iron content

Abstract

The invention belongs to the technical field of medicine, and relates to a preparation method of iron-protein succinylate with a high iron content. The preparation method comprises the following steps: (1) acylation: adding succinic anhydride into a casein solution to carry out reactions, continuously adding a sodium hydroxide solution into the reaction system to keep the pH value in a range of 6 to 9, after the reaction, adding acid into the reaction liquid to adjust the pH value to a range of 1 to 4, and filtering to obtain precipitate; (2) iron loading: dispersing the obtained precipitate into water, adding a proper amount of sodium hydroxide solution, stirring to dissolve the precipitate, then adding a ferric trichloride solution containing sodium bicarbonate into the obtained protein succinylate solution, adding a sodium hydroxide solution simultaneously to maintain the pH value of the reaction liquid in a range of 6 to 9, after the reaction filtering to remove the insoluble substances so as to obtain a iron-protein succinylate solution; refining the solution to remove the insoluble substance, adding acid to generate precipitate, filtering to obtain the precipitate, washing the precipitate by water, and finally drying the precipitate. In the recent literature, the reported iron content of iron-protein succinylate is in a range of 4.5 to 10%, while the iron content of iron-protein succinylate prepared by the provided method is as high as 15%. Moreover, the provided preparation method has the advantages of simple technology, good product solubility, and stable product quality.

Description

technical field

[0001] The invention relates to the technical field of medicine, in particular to a preparation method of iron protein succinate with high iron loading. Background technique

[0002] Iron is an essential trace element for the human body and plays an important physiological role in the human body. There are more than 70 kinds of trace elements that can be detected in the human body, which together account for 0.05% of the total amount of elements in the human body. At present, the internationally recognized trace elements necessary for the human body include iron, copper, chromium, fluorine, manganese, selenium, silicon, and tin , vanadium and zinc and other 13 kinds. Among them, iron occupies the first place. Iron is an important component of hemoglobin, myoglobin and various enzymes in human blood. Hemoglobin has the function of transporting oxygen to various tissues and organs, and carrying the carbon dioxide produced by metabolism to the lungs for remov...

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