45 results about "Iron dextran" patented technology

An iron-dextran compound for parenteral treatment of iron-deficiency anemia comprises hydrogenated dextran having a weight average molecular weight (Mw) between 700 and 1,400 Daltons, preferably approximately 1,000 Daltons, a number average molecular weight (Mn) of 400 to 1,400 Daltons and wherein 90% by weight of the dextran has molecular weights less than 2,700 Daltons and the Mw of the 10% by weight fraction of the dextran having the highest molecular weights is below 3,200 Daltons, said hydrogenated dextran having been subjected to purification by membrane processes having a cut-off value between 340 and 800 Daltons, in stable association with ferric oxyhydroxide. The compound is produced by using membrane processes to eliminate dextrans of higher molecular weights than approximately 2,700 Daltons and membrane processes to remove saccharides of molecular weights below approximately 340 Daltons from hydrogenated dextran before precipitating ferric hydroxide in the presence of said dextran followed by heat treatment and purification.

The invention relates to a method and device for eliminating sodium chloride in the aqueous solution for the complex of ferrodextran, which is characterized in that: the ferrodextran is prepared with dextran and ferric trichloride. The sodium chloride in the ferrodextran is eliminated with an electrodialysis film, that is, eliminating the sodium chloride of the solvent by electrodialysis process in the ferrodextran complex solvent with iron content is more than or equal to 40mg/ml, sodium chloride content is more than or equal to 5.0 per cent wt and viscosity of 3.0mpa is multiplied by s (20 DEG C.) under the temperature of 10 to 90 DEG C. Compared with the technique of eliminating sodium chloride with alcohol precipitation, the invention prevents the safety hazard from flammable and combustible alcohol and reduces the production cost.

In a process for producing an iron-dextran compound for use in parenteral treatment of iron-deficiency in humans or animals a stable compound of desired relatively low molecular weight is obtained by using first hydrogenation and then oxidation to convert reducing terminal groups on the dextran molecules before reaction with the iron. By varying the ratio of hydrogenated groups to oxygenated groups the average molecular weight of the resulting iron-dextran compound can be varied.

The invention discloses a preparation method of iron-dextrin. The preparation method comprises the following steps: preparing low molecular weight dextran through bi-enzyme (dextransucrase-dextranase) synergy, and then oxidizing dextran by taking sodium hypochlorite mixed liquor as an oxidizing agent, so as to obtain an oxidation-type dextran; simultaneously titrating and complexing with weak base and acid-base to prepare iron-dextrin and curing iron-dextrin under the conditions of high temperature and high pH value, so as to obtain cured iron-dextrin; filtering unreacted dextran and micromolecule iron-dextrin and ions therein with biological membranes with different molecular weights, so as to obtain purified iron-dextrin. The iron-dextrin prepared by the invention is uniform in distribution of the molecular weight, high in stability and less in content of impurities. Various indexes of iron-dextrin synthesized by the method conform to the requirements of Chinese pharmacopoeia, and the solubility of iron-dextrin is very good.

The invention belongs to the saccharide derivative preparation technology field, in particular to an isomaltose oligosaccharide and preparation process. Isomaltose oligosaccharide is a novel stable chelating biological iron, and has the excellent effect of preventing iron-deficiency anemia of a human or livestock. The productive process comprises firstly preparing or choosing activating isomaltose oligosaccharide whose average molecular weight is 1500-2000 to be purified, conducting complex reaction of activating isomaltose oligosaccharide and iron hydroxide under a certain condition, wherein iron hydroxide is formed by the reaction of inorganic ferric salt and alkali before or in the process of the complex reaction, thirdly, purifying complex compound through adopting the methods such as organic solvent deposition, ion exchange, dialysis or hyper-filtration and the like. The product which is prepared by the invention has wider iron content range from 5% to 30% compared with current iron dextran products at home and abroad, and is superior to other product in other aspects such as flowability, viscosity, stability and absorption effect.

The invention relates to an iron dextran bulk drug and a preparation method thereof. The preparation method comprises the steps of (1) alkalization of an iron salt; (2) decomposition and alkalization of dextran, comprising the procedures of dissolving the dextran in distilled water, adding an acid liquid, heating to a temperature of 80 DEG C-120 DEG C, hydrolyzing, adding an alkali liquid after the reaction is finished, and alkalizing at the temperature of 80 DEG C-120 DEG C to obtain a solution B; (3) complexation, comprising the procedures of adding a solution A obtained by the step (1) into the solution B obtained by the step (2), stirring and reacting at the temperature of 80 DEG C-120 DEG C to obtain a complexation solution; (4) alcohol precipitation; and (5) comprising procedures of performing solid-liquid separation on alcohol precipitation solution by a centrifugal machine, spray drying the solid phase and collecting powder to obtain a finished product of the iron dextran. The preparation method of the iron dextran is simple in process steps, has easily controllable reaction process, good product quality, high yield and low production cost, and is a preparation method of the iron dextran bulk drug, with relatively high innovativeness.

The invention discloses iron-dextrin injection liquid for tonifying qi-blood and used for animals. The liquid is prepared from, 5-15% w/v of iron-dextrin by iron, 1-3% w/v of radix codcnopsitis pilosulas extract, 1-3% w/v of astragalus polysaccharides, 0.003-0.008% w/v of vitamin B12, 0.003-0.008% w/v of folic acid, 1-3% w/v of vitamin E, 0.05-0.1% w/v of sodium selenite, 0.2-5% w/v of Twain-80 and the balance injection water; dextran in iron-dextrin is formed by mixing dextran with the weight average molecular weight of 5,000-6,000 Da, 6,000-6,500 Da and 6,500-7,500 Da. A preparation method of the iron-dextrin injection liquid comprises the steps that the set amount of Twain-80, folic acid and vitamin E are added to a container and evenly mixed, and then hot injection water with the amount of 10% of the total amount is added for dissolution; vitamin B12, sodium selenite, radix codcnopsitis pilosulas extract and astragalus polysaccharides are added and stirred and dissolved to obtain amixture; set iron-dextrin is added to the mixture and evenly stirred, and the injection water continues to be added. The iron-dextrin injection liquid has definite treatment effects on pregnant sowsand piglets and is worthy of popularization.

The invention provides a composite organic iron supplementing agent. The composite organic iron supplementing agent comprises the following raw materials by weight: 20 to 30 parts of ferrous fumarate, 10 to 20 parts of iron amino acid chelate, 5 to 10 parts of iron-dextran and 10 to 20 parts of ferrous lactate, wherein the iron amino acid chelate is one or a composition of a group consisting of ferrous lysinate, ferrous methioninate, ferrous glycinate and ferrous DL-threoninate. The composite organic iron supplementing agent is used as an animal iron supplementing agent and has good treatment and prevention effects on iron-deficiency anemia caused by chronic hemorrhage, malnutrition, pregnancy, growth and development periods, etc.

The invention provides a preparation method of iron dextran. In the provided preparation method, after the complexing liquid is obtained, the pH of the complexing liquid is adjusted so as to greatly improve the dissolving property of iron dextran, while during the process, intermediates, which has a molecular weight of about 180000 to 200000, and accounts for 5 to 8% of the total weight of the final product, are generated, a great amount of ions absorbs on the intermediates, because the molecular weight of the intermediates is similar to that of iron dextran, the iron dextran and intermediates cannot be separated easily through ultrafiltration, thus the ion content of the final product is high, and the iron content is influenced in some degree, so a treatment is carried out before the ultrafiltration so as to remove the intermediates. The iron content of the prepared iron dextran is much higher than the national standard (25%), and can reach 40% or more. The solubility of iron dextran in cold water can reach 4g/100g (cold water) or more, moreover, the contents of ions such as sodium iron, chlorine iron, and the like are greatly reduced, and the purity of iron dextran is higher.

The invention relates to a feed premix nutrient elements of calcium and iron. The premix comprises 1200-1600 parts of Fructus Psoraleae, 10-200 parts of calcium gluconate, 10-200 parts of cod liver oil, 5-10 parts of a bone strengthening factor and 10-20 parts of iron dextran. The additives added by the invention can help poultry or livestock to supplement rich calcium and iron and benefit fast growth and reproduction of livestock.

The invention discloses an iron dextran weight-average molecular weight and distribution coefficient stability control production method which comprises the following steps: S01, hydrolysis of dextran: hydrolyzing dextran under an acidic condition to reduce the molecular weight; s02, complexing: reacting ferric trichloride with sodium hydroxide to produce ferric hydroxide, and complexing ferric hydroxide with dextran to produce iron dextran; s03, nanofiltration: removing salt, heavy metals and free iron impurities in the complexing solution by adopting an ultrafiltration process, and concentrating the complexing solution; and S04, spray drying: adding the qualified ultrafiltration solution into spray drying equipment, and carrying out spray drying to obtain powder. The iron dextran with stable weight-average molecular weight and distribution coefficient is produced, and the weight-average molecular weight (Mw) of the iron dextran raw material and the preparation is accurately controlled to be about 6000, so that the internal quality and the clinical treatment effect of the iron dextran raw material and the preparation are improved.

The invention relates to a suspension injection containing iron-dextran and ponazuril. The suspension injection is further prepared from pharmaceutically acceptable silicone oil, lecithin, a metal ion complexing agent, n-butyl alcohol, povidone, water and an optional pH regulator. The suspension injection is stable, good in safety and high in bioavailability, and capable of preventing and treating coccidiosis infection and iron-deficiency anemia of animals at the same time.

The invention relates to a breeding method for improving the growth speed of pigs, and belongs to the technical field of breeding. The method includes the following steps that 1, before newborn pigs are fed for the first time, each newborn pig is drenched with 1-2 ml of medicinal liquid, and the drenching is conducted twice a day for three days in a row; 2, on the third day, the seventh day, and the thirty-fifth day after the pigs are born, iron dextran is injected; 3, 28 days after being born, the pigs are weaned, 7 days before the weaning, the pigs are fed with creep feed, and on the eighth to the tenth days, creep feed and nursing early-stage feed are adopted to feed the pigs; after 11 days, weaning early-stage feed is adopted to feed the pigs till the weights of the pigs are 30 jin, and after the weights of the pigs reach 30 jin, the pigs eat feed freely. The breeding method for improving the growth speed of the pigs can prevent the occurrence of white and yellow scour of piglets, improve the immunity and disease resistance of the pigs and increase the growth speed of the pigs, the survival rate can be increased by 20%, the maximum weight gain rate can reach 25%, the pigs are ready for slaughter 8-12 days ahead of time, the feeding period is shortened, the labor cost is reduced, the feeding consumption is reduced, and the economic benefits of farmers are increased.

The technical scheme of the invention discloses feed for improving the pork quality of fattening pigs. The feed is prepared from the following raw materials: corns, barley with shells, third-class flour, soybean meal having the protein content of 46 percent, wheat bran, soybean oil, calcium carbonate, calcium hydrophosphate, vitamin complex, mineral elements, iron dextran, probiotics, lysine sulfate having a concentration of 70 percent, L-threonine having a concentration of 98 percent, DL-methionine having a concentration of 99 percent, L-tryptophan having a concentration of 98.5 percent, guanidinoacetic acid, choline chloride, baking soda and sodium chloride. According to the feed, by adding additives for promoting muscle protein deposition, improving glucose metabolism and protein anabolism of the fattening pigs, the lean meat percentage and daily gain of the fattening pigs can be improved, and the pork quality can be improved.

The invention discloses iron dextran compound oral liquid which is prepared from the following raw materials: 20-40kg of iron dextran, 1-5kg of donkey-hide gelatin, 5-13kg of taurine, 10-50kg of sucrose, 0.35kg of benzoic acid and a proper amount of purified water. The invention also provides a preparation technology of the iron dextran compound oral liquid, which comprises the steps of (A) fetching the purified water, adding the donkey-hide gelatin of the formula dosage, and standing until the donkey-hide gelatin is completely dissolved; (B) fetching the purified water, adding the taurine of the formula dosage, and completely dissolving the taurine; (C) fetching the iron dextran of the formula dosage and the mixed liquid in the step (B), sequentially adding into the prepared mixed liquid in the step (A), and mixing uniformly. The oral liquid disclosed by the invention is widely applied to the iron-deficiency anemia caused by chronic blood loss, malnutrition, developmental phase and the like, and also can be used as an adjuvant therapy for anemia diseases of operation recovery, the liver and kidney, the heart, the skin and the like.

The invention discloses a livestock traditional Chinese medicine composition having functions of nourishing, fattening, tonifying qi and nourishing blood. The composition comprises following components by weight: 10-30 parts of basket fern rhizome, 10-40 parts of fleece-flower root, 10-20 parts of malt, 10-20 parts of soybean, and 1-10 parts of iron-dextrin. The formulation of the composition is scientific and reasonable. The composition has the functions of nourishing, fattening, tonifying qi and nourishing blood. The composition is free of toxic and side effects and medicine residues, and is convenient to use and low in cost. The composition can be used for treating common emaciation, slow growth, and the like for livestock.

The invention discloses a method for controlling the feed ratio of iron-dextran production by measuring the content of sugar anhydride. The method comprises the following steps of (1) detecting the iron content in an iron-dextran complexing solution, (2) preparing a test sample from the iron-dextran complexing solution, (3) sequentially cooling a sample to be tested, mixing the sample with an anthrone sulfuric acid solution, heating, cooling, and determining absorbance, (4) using water as blank control, (5) preparing the D-glucosum anhydricum into five standard solutions with different concentrations, (6) respectively measuring the absorbance of the five standard solutions with different concentrations, and making a standard curve according to the concentrations and the absorbance to obtain an equation, (7) calculating the absorbance of the sample to be tested according to the equation in the step (6) to obtain the concentration of glucose, and converting to obtain the content of the sugar anhydride, and (8) according to the iron content and the content of the sugar anhydride, converting the content of the sugar anhydride in the product with the corresponding specification, so as to adjust and control the feeding ratio of the sugar anhydride to the iron in the production process of the iron dextran.

The invention discloses a method for synthesizing iron dextran and its dispersible tablets, comprising the following steps: (1) preparing dextran 20 into a dextran hydrolyzate, weighing ferric chloride to prepare a ferric chloride solution; (2) preparing the dextran Add the hydrolyzate and ferric chloride solution into the reaction tank and mix evenly, adjust the pH of the obtained reaction solution to 10‑11, then heat to boiling state, and react to obtain the complex solution; (3) the obtained complex solution The pH of the solution is adjusted to 6.3-6.8 with hydrochloric acid solution, and then the finished product of iron dextran is obtained after being subjected to coarse filtration, medium filtration and ultrafiltration, and spray drying. The invention provides a method for synthesizing iron dextran and its dispersible tablets. Through the pH value adjustment before and after the complexation reaction and the design of the ceramic ultrafiltration membrane, the iron content and dissolution rate can be increased, the impurity content can be reduced, and the production efficiency can also be improved.