Iron dextran bulk drug and preparation method thereof

Abstract

The invention relates to an iron dextran bulk drug and a preparation method thereof. The preparation method comprises the steps of (1) alkalization of an iron salt; (2) decomposition and alkalization of dextran, comprising the procedures of dissolving the dextran in distilled water, adding an acid liquid, heating to a temperature of 80 DEG C-120 DEG C, hydrolyzing, adding an alkali liquid after the reaction is finished, and alkalizing at the temperature of 80 DEG C-120 DEG C to obtain a solution B; (3) complexation, comprising the procedures of adding a solution A obtained by the step (1) into the solution B obtained by the step (2), stirring and reacting at the temperature of 80 DEG C-120 DEG C to obtain a complexation solution; (4) alcohol precipitation; and (5) comprising procedures of performing solid-liquid separation on alcohol precipitation solution by a centrifugal machine, spray drying the solid phase and collecting powder to obtain a finished product of the iron dextran. The preparation method of the iron dextran is simple in process steps, has easily controllable reaction process, good product quality, high yield and low production cost, and is a preparation method of the iron dextran bulk drug, with relatively high innovativeness.

Description

technical field

[0001] The invention belongs to the field of veterinary drugs, in particular to an iron dextran raw material medicine and a preparation method thereof. Background technique

[0002] In the feeding process of piglets, the intake of iron is very important. Iron is a trace element necessary for the body. It is an essential component for the body to synthesize hemoglobin. It is also myoglobin, cytochrome, and cytochrome. Components such as enzymes and peroxidases. Primary iron deficiency can cause anemia in newborn piglets. According to statistics, about 30% of piglets die due to iron deficiency. Piglets suffering from anemia mainly occur at the age of 2 to 4 weeks, and the faster the piglets grow, the more iron they store. The faster the amount is consumed, the higher the incidence of anemia. If the iron element is not supplemented in time, it will bring the following unfavorable factors to piglets: (1) cannot form hemoglobin, myoglobin, cytochrome enzymes and...

Images