Iron dextran bulk drug and preparation method thereof

A technology for iron dextran and dextran, which is applied in the field of iron dextran raw materials and preparation thereof, can solve the problems of oxygen-carrying, low oxygen supply capacity, low hemoglobin content, decreased physiological function and the like, and achieves easy control of the reaction process, simple process steps, The effect of low production cost

Inactive Publication Date: 2013-04-17
TIANJIN ZHONGAO BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

If the iron element is not supplemented in time, it will bring the following unfavorable factors to piglets: (1) cannot form hemoglobin, myoglobin, cytochrome enzymes and various peroxidases, thereby affecting the delivery of nutrients in the body; (2) Low hemoglobin content, low oxygen-carrying and oxygen-supplying capacity, can easily cause body organ failure; (3) increased incidence of diarrhea, edema, white muscle disease, etc., slow growth, rough back hair, pale skin and mucous membranes, and loss of appetite; ( 4) Physiological function decline, low immunity, susceptibility to infection and secondary diseases

Method used

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  • Iron dextran bulk drug and preparation method thereof
  • Iron dextran bulk drug and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0020] A preparation method of iron dextran bulk drug, the steps of the preparation method are:

[0021] (1), ferric salt alkalization: dissolve 10 parts of ferric chloride in 40 parts of distilled water, add 10 parts of 20% sodium hydroxide solution at 10-30 ° C, adjust the pH value to 5, and filter out the resulting The reddish-brown precipitate is washed 4 times with distilled water, and then put into 40 parts of distilled water to obtain solution A for subsequent use; the iron salt can also be ferric nitrate, ferric citrate, ferric acetate, ferric perchlorate, ferric ammonium citrate , ferric ammonium nitrate or iron glycerophosphate; the alkaline solution can also be one of sodium carbonate solution, potassium hydroxide solution, ammonium hydroxide solution or potassium carbonate solution.

[0022] (2), decomposition and alkalization of sugar anhydride: dissolve 10 parts of dextran in 30 parts of distilled water, add 10 parts of concentrated hydrochloric acid, heat up to ...

Embodiment 2

[0028] A preparation method of iron dextran bulk drug, the steps of the preparation method are:

[0029] (1), ferric salt alkalization: dissolve 1 part of iron nitrate in 10 parts of distilled water, add 1 part of 10% sodium carbonate solution at 10 ° C, adjust the pH value to 3, filter out the reddish-brown precipitate produced, and use Rinse 2 times with distilled water, then put into 10 parts of distilled water to obtain solution A for later use;

[0030] (2) Decomposition and alkalization of sugar anhydride: Dissolve 1 part of dextran in 10 parts of distilled water, add 1 part of concentrated sulfuric acid, heat up to 80°C, hydrolyze for 0.5 hour, add 1 part of 10% sodium carbonate solution after the reaction is over, Alkaline at 80°C for 1 hour to obtain solution B;

[0031] (3) Complexation: adding solution A obtained in step (1) to solution B obtained in step (2), stirring and reacting at 80° C. for 1 hour to obtain a complexing solution;

[0032] (4), when the comple...

Embodiment 3

[0035] A preparation method of iron dextran bulk drug, the steps of the preparation method are:

[0036] (1), alkalization of iron salt: dissolve 5 parts of iron salt in 20 parts of distilled water, add 5 parts of 20% alkali solution at 20°C, adjust the pH value to 4, filter out the reddish-brown precipitate produced, and use distilled water Rinse 3 times, then put into 20 parts of distilled water to obtain solution A for later use;

[0037] (2) Decomposition and alkalization of sugar anhydride: Dissolve 5 parts of dextran in 20 parts of distilled water, add 5 parts of acid solution, heat up to 100°C, hydrolyze for 1.5 hours, add 20 parts of 20% lye after the reaction, and heat Alkaline at high temperature for 2 hours to obtain solution B;

[0038] (3), complexation: adding solution A obtained in step (1) to solution B obtained in step (2), stirring and reacting at 100° C. for 2 hours to obtain a complexing solution;

[0039] (4), when the complex solution obtained in step (...

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Abstract

The invention relates to an iron dextran bulk drug and a preparation method thereof. The preparation method comprises the steps of (1) alkalization of an iron salt; (2) decomposition and alkalization of dextran, comprising the procedures of dissolving the dextran in distilled water, adding an acid liquid, heating to a temperature of 80 DEG C-120 DEG C, hydrolyzing, adding an alkali liquid after the reaction is finished, and alkalizing at the temperature of 80 DEG C-120 DEG C to obtain a solution B; (3) complexation, comprising the procedures of adding a solution A obtained by the step (1) into the solution B obtained by the step (2), stirring and reacting at the temperature of 80 DEG C-120 DEG C to obtain a complexation solution; (4) alcohol precipitation; and (5) comprising procedures of performing solid-liquid separation on alcohol precipitation solution by a centrifugal machine, spray drying the solid phase and collecting powder to obtain a finished product of the iron dextran. The preparation method of the iron dextran is simple in process steps, has easily controllable reaction process, good product quality, high yield and low production cost, and is a preparation method of the iron dextran bulk drug, with relatively high innovativeness.

Description

technical field [0001] The invention belongs to the field of veterinary drugs, in particular to an iron dextran raw material medicine and a preparation method thereof. Background technique [0002] In the feeding process of piglets, the intake of iron is very important. Iron is a trace element necessary for the body. It is an essential component for the body to synthesize hemoglobin. It is also myoglobin, cytochrome, and cytochrome. Components such as enzymes and peroxidases. Primary iron deficiency can cause anemia in newborn piglets. According to statistics, about 30% of piglets die due to iron deficiency. Piglets suffering from anemia mainly occur at the age of 2 to 4 weeks, and the faster the piglets grow, the more iron they store. The faster the amount is consumed, the higher the incidence of anemia. If the iron element is not supplemented in time, it will bring the following unfavorable factors to piglets: (1) cannot form hemoglobin, myoglobin, cytochrome enzymes and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/02A61P3/02
Inventor 安同伟陈庆忠郭嘉
Owner TIANJIN ZHONGAO BIOTECH
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