Iron dextran bulk drug and preparation method thereof
A technology for iron dextran and dextran, which is applied in the field of iron dextran raw materials and preparation thereof, can solve the problems of oxygen-carrying, low oxygen supply capacity, low hemoglobin content, decreased physiological function and the like, and achieves easy control of the reaction process, simple process steps, The effect of low production cost
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Embodiment 1
[0020] A preparation method of iron dextran bulk drug, the steps of the preparation method are:
[0021] (1), ferric salt alkalization: dissolve 10 parts of ferric chloride in 40 parts of distilled water, add 10 parts of 20% sodium hydroxide solution at 10-30 ° C, adjust the pH value to 5, and filter out the resulting The reddish-brown precipitate is washed 4 times with distilled water, and then put into 40 parts of distilled water to obtain solution A for subsequent use; the iron salt can also be ferric nitrate, ferric citrate, ferric acetate, ferric perchlorate, ferric ammonium citrate , ferric ammonium nitrate or iron glycerophosphate; the alkaline solution can also be one of sodium carbonate solution, potassium hydroxide solution, ammonium hydroxide solution or potassium carbonate solution.
[0022] (2), decomposition and alkalization of sugar anhydride: dissolve 10 parts of dextran in 30 parts of distilled water, add 10 parts of concentrated hydrochloric acid, heat up to ...
Embodiment 2
[0028] A preparation method of iron dextran bulk drug, the steps of the preparation method are:
[0029] (1), ferric salt alkalization: dissolve 1 part of iron nitrate in 10 parts of distilled water, add 1 part of 10% sodium carbonate solution at 10 ° C, adjust the pH value to 3, filter out the reddish-brown precipitate produced, and use Rinse 2 times with distilled water, then put into 10 parts of distilled water to obtain solution A for later use;
[0030] (2) Decomposition and alkalization of sugar anhydride: Dissolve 1 part of dextran in 10 parts of distilled water, add 1 part of concentrated sulfuric acid, heat up to 80°C, hydrolyze for 0.5 hour, add 1 part of 10% sodium carbonate solution after the reaction is over, Alkaline at 80°C for 1 hour to obtain solution B;
[0031] (3) Complexation: adding solution A obtained in step (1) to solution B obtained in step (2), stirring and reacting at 80° C. for 1 hour to obtain a complexing solution;
[0032] (4), when the comple...
Embodiment 3
[0035] A preparation method of iron dextran bulk drug, the steps of the preparation method are:
[0036] (1), alkalization of iron salt: dissolve 5 parts of iron salt in 20 parts of distilled water, add 5 parts of 20% alkali solution at 20°C, adjust the pH value to 4, filter out the reddish-brown precipitate produced, and use distilled water Rinse 3 times, then put into 20 parts of distilled water to obtain solution A for later use;
[0037] (2) Decomposition and alkalization of sugar anhydride: Dissolve 5 parts of dextran in 20 parts of distilled water, add 5 parts of acid solution, heat up to 100°C, hydrolyze for 1.5 hours, add 20 parts of 20% lye after the reaction, and heat Alkaline at high temperature for 2 hours to obtain solution B;
[0038] (3), complexation: adding solution A obtained in step (1) to solution B obtained in step (2), stirring and reacting at 100° C. for 2 hours to obtain a complexing solution;
[0039] (4), when the complex solution obtained in step (...
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