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Suspension injection of iron-dextran and ponazuril and preparation method thereof

The technology of iron dextran and injection is applied in the directions of non-active ingredient medical preparations, active ingredients-containing medical preparations, pharmaceutical formulas, etc., and can solve the problems of increasing the cost of drugs, affecting the growth and development of animals, affecting the economic benefits of breeding, and the like, To achieve the effect of improving animal welfare, reducing dosing workload, and reducing the risk of gas embolism

Pending Publication Date: 2021-08-06
HUBEI LONGXIANG PHARMA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] This single-disease, single-treatment model has brought huge workload to the farmers, increased the cost of drugs, and brought huge pressure to the animals, affecting the normal growth and development of animals, and ultimately affecting the economic benefits of farming.

Method used

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  • Suspension injection of iron-dextran and ponazuril and preparation method thereof
  • Suspension injection of iron-dextran and ponazuril and preparation method thereof
  • Suspension injection of iron-dextran and ponazuril and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] Embodiment 1 comprises the preparation of the suspension injection 1 of Patopazuril and iron dextran

[0066] 1. Prescription composition:

[0067]

[0068] 2. Preparation method:

[0069] S1. Take an appropriate amount of water for injection into the liquid mixing tank, add the prescribed amount of iron dextran in 2 to 4 times, and stir at 60-80°C with a high-shear emulsifier at 4000-5000 rpm after all the input 30min, obtain initial solution I, cooling standby;

[0070] S2. Put disodium edetate and povidone in the initial solution I into the initial solution I, fully stir and dissolve to obtain the mixed solution II;

[0071] S3. Add the prescribed amount of n-butanol and lecithin to the mixed solution II, heat and stir at 50-70°C until completely dissolved to obtain the suspension III, and cool it for later use;

[0072] S4. Add the prescribed amount of simethicone and Patopazuril to the suspension III, stir for 30 minutes at 4000-5000 rpm with a high-shear emu...

Embodiment 2

[0074] Embodiment 2 comprises the preparation of the suspension injection 2 of Patopazuril and iron dextran

[0075] 1. Prescription composition

[0076]

[0077] 2. The preparation method is the same as in Example 1.

Embodiment 3

[0078] Embodiment 3 comprises the preparation of the suspension injection 3 of Patopazuril and iron dextran

[0079] 1. Prescription composition:

[0080]

[0081] 2. The preparation method is the same as in Example 1.

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Abstract

The invention relates to a suspension injection containing iron-dextran and ponazuril. The suspension injection is further prepared from pharmaceutically acceptable silicone oil, lecithin, a metal ion complexing agent, n-butyl alcohol, povidone, water and an optional pH regulator. The suspension injection is stable, good in safety and high in bioavailability, and capable of preventing and treating coccidiosis infection and iron-deficiency anemia of animals at the same time.

Description

technical field [0001] The invention belongs to the technical field of veterinary drugs, and in particular relates to a suspension injection containing iron dextran and patopazuril and a preparation method thereof, which are suitable for simultaneously preventing and treating coccidiosis and iron-deficiency anemia in animals. Background technique [0002] Coccidiosis and iron deficiency anemia are animal diseases that frequently appear in the process of modern animal husbandry. They occur frequently in young animals. The incidence is high and the disease aggravates rapidly, seriously affecting the growth and development of animals, and even causing death. [0003] Piglets have very limited iron storage (40-50 mg) at birth and iron (about 1 mg / d) obtained from breast milk during lactation, which leads to iron deficiency in piglets in the first week after birth. Clinically, intramuscular injection of iron or indirect iron supplementation to sows is mainly used. Due to the limi...

Claims

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Application Information

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IPC IPC(8): A61K9/10A61K47/10A61K47/18A61K47/34A61K31/721A61K33/26A61K31/53A61P33/02A61P7/06A61P3/02
CPCA61K9/10A61K9/0019A61K47/10A61K47/183A61K47/34A61K31/721A61K33/26A61K31/53A61P33/02A61P7/06A61P3/02A61K2300/00
Inventor 陈清平卢山王铭宏
Owner HUBEI LONGXIANG PHARMA TECH CO LTD
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