Short-T2-effect endorectal/endovaginal magnetic resonance imaging contrast agent and preparation method thereof

Abstract

The invention discloses a short-T2-effect endorectal / endovaginal magnetic resonance imaging contrast agent and a preparation method thereof. The short-T2-effect endorectal / endovaginal magnetic resonance imaging contrast agent comprises iron dextran, an ultrasonic coupling agent and water. The short-T2-effect endorectal / endovaginal magnetic resonance imaging contrast agent has the beneficial effects that the iron dextran, the ultrasonic coupling agent and the water are mixed according to a specified proportion to prepare the contrast agent, so that the T2 relaxation time of the ultrasonic coupling agent during magnetic resonance imaging is shortened, the signal strength of the ultrasonic coupling agent on a T2-weighted imaging is reduced, and interference of the ultrasonic coupling agent tolesion display during endorectal / endovaginal magnetic resonance imaging is reduced; the contrast agent has attachment performance with cavity organs such as the rectum / vagina, is a non-liquid colloid, can be properly formed and is not required to be contained in a specific container, the cavity organs such as the rectum / vagina can be well filled, and the rectum or the vagina can be directly filled with the contrast agent; each component is stable, and the contrast agent is long in shelf life and convenient to store.

Description

technical field [0001] The invention relates to the field of medical preparations, in particular to a short T2 effect rectal / vaginal cavity magnetic resonance imaging contrast agent and a preparation method thereof. Background technique [0002] Magnetic Resonance Imaging (MRI for short) is an imaging technique that uses the signal generated by the resonance of atomic nuclei in a magnetic field to reconstruct the image. As a new medical imaging diagnosis technology, it has developed rapidly in recent years. The amount of information provided by magnetic resonance imaging is not only more than that of many other imaging techniques, but also has great potential advantages in diagnosing diseases with the unique information it provides. In magnetic resonance imaging, good image quality is the basis of all clinical diagnosis and research. Therefore, high-quality images are the primary condition for doctors to correctly study, judge, diagnose and treat patients' lesions. [0003]...

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Problems solved by technology

[0004] At present, the filling agent commonly used in clinical MRI examination and diagnosis of rectum and vagina is ultrasonic coupling agent. Cavity organs can eliminate the influence of cavity and intestinal contents to improve the display of lesions. It is helpful for MRI examination and diagnosis of rectum and vagina. Compared with water as a filling agent, ultrasonic coupling agent has no effect. Fluidity, can be properly molded, does not require a specific container, can be directly filled in the rectum or vagina; long shelf life, convenient storage, but, in the magnetic resonance imaging, the ultrasonic coupling agent is high signal on T2-weighted imaging, which directly It affects the display of lesions, such as colorectal cancer, especially in diffusion-weighted images (Diffusion-weighted Image, referred to as DWI), which will affect the T2 penetration effect, making the ultrasound coupling agent confused with the diffusion-limited human tissue lesion mass, This seriously affects the MRI examination and diagnosis of the rectum and vagina, and ultimately affects the treatment effect. At present, in clinical practice, an ideal MRI contrast agent for the rectum and vagina that does not confuse the display of lesions is still in a vacancy, so , a magnetic resonance imaging contrast agent that can clearly display rectal and vaginal lesions is an urgent need for clinical and scientific research

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