Iron dextran particles and preparation process thereof

Abstract

A preparation process of iron-dextrin particles. The raw materials contain 250 grams of iron-dextrin, 12000 grams of lactose and 7000 grams of starch, 50 grams of povidone K30 and 25 grams of aspartame. The preparation process comprises the steps of: sieving iron-dextrin, lactose, maltodextrin, povidone K30 and aspartame respectively through a 80 mesh sieve for standby; weighing accessories and the main drug according to the prescription, and uniformly mixing; Adding an adhesive for prepare a soft material; granulating by a 16 mesh sieve; drying at 60 DEG C; finishing the grains by a 12 mesh sieve; determining particle content; determine a bag weight; and packaging. A traditional preparation process of iron-dextrin particles requires particle preparation and tabletting, has long production cycle and high production cost; and the process of the invention can directly prepare the particles, does not need tabletting, and has shortened production cycle and simple process. The additional flavoring agent improves the taste, and improves the patient medication compliance in order to meet the needs of medical treatment.

Description

technical field [0001] The invention relates to the technical field of granules, in particular to a granule containing iron dextran and a preparation process thereof Background technique [0002] This product is a complex of dextran and iron, which is soluble iron. Iron dextran is decomposed by dextran in the small intestinal mucosa and colon, and elemental iron is absorbed and utilized by the body. Because this product can affect the activity of acetyl coenzyme A, succinate dehydrogenase, xanthine oxidase, and cytochrome reductase, and participate in the synthesis of hemoglobin and cytokines, it can obviously promote the nuclear division of hematopoietic stem cells, thereby promoting the synthesis of hemoglobin . Iron is a constituent element of hemoglobin in red blood cells. When iron is deficient, the amount of hemoglobin synthesized by red blood cells decreases, resulting in smaller red blood cells and reduced oxygen-carrying capacity, resulting in iron-deficiency ane...

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Problems solved by technology

Spraque-dawley mice were given large doses of iron dextran (100mg / kg iron for 7 days) for a short period of time, and the anatomical and histological study of the animal liver found that iron deposition appeared in the liver cells, but no damage to the liver cells was seen

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