A kind of production method of iron dextran product that disintegrates quickly in pig oral cavity

A technology of iron dextran and its production method, which is applied in the field of pig breeding, can solve the problems that pigs are prone to stress reactions, and achieve the effects of reducing sensitivity, enhancing absorption and transformation, and reducing stress reactions

Active Publication Date: 2021-03-30
安徽万士生物制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a method for producing iron dextran products that rapidly disintegrate in the oral cavity of pigs. The iron dextran products prepared by wrapping in the present invention are used for oral use and can be subsidized directly in the oral cavity of pigs, which solves the problem There is a problem that pigs are prone to stress reactions when injected, and at the same time save time and effort by oral iron supplementation

Method used

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  • A kind of production method of iron dextran product that disintegrates quickly in pig oral cavity
  • A kind of production method of iron dextran product that disintegrates quickly in pig oral cavity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A production method of an iron dextran product that disintegrates rapidly in the oral cavity of pigs, comprising the steps of:

[0029] Step 1. Drug preparation and configuration: use iron dextran as the main ingredient and add ingredients to configure the inner core layer mixture solution for later use; use pregelatinized starch and jujube powder as raw materials, add ingredients and water and stir evenly to obtain the outer coating solution for later use; use NaCl and CaCl 2 It is configured into a concentration of 2wt% mixed solution as a receiving solution for subsequent use;

[0030] Step 2, wrapping preparation: use the drug wrapping instrument to prepare granular iron dextran products with the drug solution prepared in step 1.

[0031] Among them, the ingredients include sodium selenite, emulsifier, Tween, glycerin, dextrin, lactose, vitamin B1 and vitamin B6.

[0032] Wherein, the drug components in the inner core layer mixture solution include 5% iron dextran...

Embodiment 2

[0043] A production method of an iron dextran product that disintegrates rapidly in the oral cavity of pigs, comprising the steps of:

[0044] Step 1. Drug preparation and configuration: use iron dextran as the main ingredient and add ingredients to configure the inner core layer mixture solution for later use; use pregelatinized starch and jujube powder as raw materials, add ingredients and water and stir evenly to obtain the outer coating solution for later use; use NaCl and CaCl 2 It is configured to a concentration of 4wt% mixed solution as a receiving solution for subsequent use;

[0045] Step 2, wrapping preparation: use the drug wrapping instrument to prepare granular iron dextran products with the drug solution prepared in step 1.

[0046] Among them, the ingredients include sodium selenite, emulsifier, Tween, glycerin, dextrin, lactose, vitamin B1 and vitamin B6.

[0047] Wherein, the drug components in the inner core layer mixture solution include 8% iron dextran, ...

Embodiment 3

[0058] Piglet Iron Deficiency Experiment

[0059] Target: 30 10-day-old piglets, divided into 3 groups A, B, C, 10 piglets in each group;

[0060] Group A: fed with existing conventional non-iron-supplemented feed every day,

[0061] Group B: fed with existing conventional iron-supplemented feed every day,

[0062] Group C: use existing conventional non-iron-supplementing feed to feed and simultaneously feed 10-20g of the iron dextran product prepared by the present invention every day;

[0063] Respectively detect and feed the hemoglobin content in the blood of piglets for 4 days, 10 days, 15 days and 20 days and make statistics, and the statistical results are as shown in Table 1:

[0064]

[0065] As shown in Table 1 above, using the iron dextran product prepared by the present invention for feeding piglets has a good iron supplement effect on piglets.

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Abstract

The invention discloses a production method of an iron dextran product capable of being rapidly disintegrated in oral cavities of pigs and relates to the technical field of pig breeding. The production method comprises the following steps: step 1, preparing a medicament: taking iron dextran as a main material and adding auxiliary materials to prepare an inner-core layer mixture solution for lateruse; taking pre-gelatinized starch and jujube powder as raw materials; adding auxiliary materials and water, and uniformly stirring to obtain an outer-layer covering solution for later use; preparingNaCl and CaCl2 into a mixed solution with the concentration of 1 to 5 weight percent and taking the mixed solution as a receiving solution for later use; step 2, covering and preparing: preparing a medicine solution prepared by step 1 into the granular iron dextran product by utilizing a medicine covering instrument. According to the production method disclosed by the invention, the iron dextran product is prepared by covering is used for oral administration and is directly put into the oral cavities of the pigs to carry out patching; the problem that the pigs easily have stress response in anexisting injection process is solved; meanwhile, iron is supplemented through the oral administration, and time and labor are saved.

Description

technical field [0001] The invention belongs to the technical field of pig breeding, and in particular relates to a production method of iron dextran product which rapidly disintegrates in the oral cavity of pigs. Background technique [0002] Iron dextran is a complex compound formed by complexing ferric hydroxide and dextran through advanced technology. It is prepared with sodium selenite, filtered and sterilized by hot pressure to make dextran iron selenium injection, which is mainly used to prevent and treat piglets. selenium deficiency and iron deficiency anemia. [0003] A large number of studies have shown that there is only about 50 mg of iron in piglets at birth, and they need 7 mg of iron per day to meet their growth needs, while piglets can only obtain 1 mg of iron from sow milk per day. If it can be supplemented, it will not be able to meet its growth needs and produce iron deficiency anemia, resulting in growth retardation, weight loss, low disease resistance, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/50A61K47/36A61K47/46A61K33/26A61P7/06A61P3/02A61K31/51A61K31/4415
CPCA61K9/5036A61K9/5063A61K31/4415A61K31/51A61K33/26A61P3/02A61P7/06A61K2300/00
Inventor 徐双贵胡培李少海
Owner 安徽万士生物制药有限公司
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