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Method for controlling feed ratio of iron-dextran production by measuring content of sugar anhydride

A technology for iron dextran and dextran, which is applied in the field of controlling the production feed ratio of iron dextran, can solve the problems such as the method for adjusting and control the production feed ratio of iron dextran, and achieves the effects of small error, good stability and linearity, and high accuracy

Pending Publication Date: 2021-10-29
广西南宁市桃源兽药厂
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the production of iron dextran, there are usually customers who have certain requirements for the content of glucosinolate in iron dextran products. At present, there is no method to adjust and control the feeding ratio of iron dextran production according to the requirements of glycosan content in the final product.

Method used

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  • Method for controlling feed ratio of iron-dextran production by measuring content of sugar anhydride
  • Method for controlling feed ratio of iron-dextran production by measuring content of sugar anhydride
  • Method for controlling feed ratio of iron-dextran production by measuring content of sugar anhydride

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Embodiment 1

[0030] A method for controlling iron dextran production feed ratio by measuring sugar anhydride content, comprising the following steps:

[0031] (1) In the complexing process of the production link, the feeding amount of the ferric chloride solution is determined according to the feeding amount of the dextran, and the feeding amount is determined by the iron content of the ferric chloride solution. When the iron ratio is 1:0.7, accurately weigh 1g of its iron dextran complex solution, and measure the specific gravity of the sample according to the method for detecting the iron content in iron dextran in "The Veterinary Pharmacopoeia of the People's Republic of China", and calculate the concentration of the iron dextran in the complex solution. iron content;

[0032] (2) Preparation of the test sample: Accurately weigh 1g of the above-mentioned iron dextran complex solution, add water to dilute to 500mL, take this diluted solution 10mL and then dilute to 100mL to obtain the te...

Embodiment 2

[0039] A method for controlling iron dextran production feed ratio by measuring sugar anhydride content, comprising the following steps:

[0040] (1) In the complexing process of the production link, the feeding amount of the ferric chloride solution is determined according to the feeding amount of the dextran, and the feeding amount is determined by the iron content of the ferric chloride solution. When the iron ratio is 1:0.8, accurately weigh 1g of its iron dextran complex solution, and measure the specific gravity of the sample according to the method for detecting the iron content in iron dextran in "The Veterinary Pharmacopoeia of the People's Republic of China", and calculate the concentration of the iron dextran in the complex solution. iron content;

[0041](2) Preparation of the test sample: Accurately weigh 1g of the above-mentioned iron dextran complex solution, add water to dilute to 500mL, take this diluted solution 10mL and then dilute to 100mL to obtain the tes...

Embodiment 3

[0048] A method for controlling iron dextran production feed ratio by measuring sugar anhydride content, comprising the following steps:

[0049] (1) In the complexing process of the production link, the feeding amount of the ferric chloride solution is determined according to the feeding amount of the dextran, and the feeding amount is determined by the iron content of the ferric chloride solution. When the iron ratio is 1:0.9, accurately weigh 1g of its iron dextran complex solution, and measure the specific gravity of the sample according to the method for detecting iron content in iron dextran in "The Veterinary Pharmacopoeia of the People's Republic of China", and calculate the concentration of the iron dextran in the complex solution. iron content;

[0050] (2) Preparation of the test sample: Accurately weigh 1g of the above-mentioned iron dextran complex solution, add water to dilute to 500mL, take this diluted solution 10mL and then dilute to 100mL to obtain the test s...

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Abstract

The invention discloses a method for controlling the feed ratio of iron-dextran production by measuring the content of sugar anhydride. The method comprises the following steps of (1) detecting the iron content in an iron-dextran complexing solution, (2) preparing a test sample from the iron-dextran complexing solution, (3) sequentially cooling a sample to be tested, mixing the sample with an anthrone sulfuric acid solution, heating, cooling, and determining absorbance, (4) using water as blank control, (5) preparing the D-glucosum anhydricum into five standard solutions with different concentrations, (6) respectively measuring the absorbance of the five standard solutions with different concentrations, and making a standard curve according to the concentrations and the absorbance to obtain an equation, (7) calculating the absorbance of the sample to be tested according to the equation in the step (6) to obtain the concentration of glucose, and converting to obtain the content of the sugar anhydride, and (8) according to the iron content and the content of the sugar anhydride, converting the content of the sugar anhydride in the product with the corresponding specification, so as to adjust and control the feeding ratio of the sugar anhydride to the iron in the production process of the iron dextran.

Description

technical field [0001] The invention belongs to the technical field of drug detection and production, and in particular relates to a method for controlling the feeding ratio of iron dextran production by measuring the content of glucosinolate. Background technique [0002] Iron dextran complex solution is obtained by chemical (complexing) reaction of dextran with ferric chloride solution after hydrolysis and alkalization, and is an intermediate product in the production process of iron dextran. Iron dextran (iron dextran) is the raw material of iron dextran for injection. It is suitable for iron deficiency anemia in foals, calves, piglets, puppies and fur animals. It is an anti-anemia drug. Iron is the main component of hemoglobin and myoglobin, which is the main oxygen carrier in red blood cells. Myoglobin is the place where muscle cells store oxygen to meet the oxygen supply needs of muscles during exercise. Most enzymes and factors involved in the Krebs cycle contain ir...

Claims

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Application Information

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IPC IPC(8): G01N21/31
CPCG01N21/31
Inventor 王光娥韦芳漫吴寿婵
Owner 广西南宁市桃源兽药厂
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