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Oral liquid capable of lowering blood pressure and resisting thrombus

An oral liquid and antithrombotic technology, applied in the field of oral liquid, can solve the problems of resource waste, waste disposal, etc., and achieve the effects of reducing shedding, improving fluidity, and improving biological activity

Active Publication Date: 2019-09-20
安徽草珊瑚生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The amount of kelp cultured in China is in a leading position at home and abroad, and its fucoidan content reaches 3.6%, which is the brown algae with the highest fucose content in the brown algae resources in my country. The kelp is rich in sodium alginate, iodine and mannitol, and the processing produces a large amount of fucoidan, which is often discarded as waste, resulting in a great waste of resources
At present, there are relatively few studies on the preparation and application of fucoidan sulfate, especially low molecular weight laminaria fucoidan sulfate.

Method used

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  • Oral liquid capable of lowering blood pressure and resisting thrombus
  • Oral liquid capable of lowering blood pressure and resisting thrombus
  • Oral liquid capable of lowering blood pressure and resisting thrombus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] A method for preparing fucoidan, comprising:

[0047] Weigh 5 g of dry kelp powder, add 312.5 mL of distilled water, ultrasonically treat at 65 ° C for 60 min, then add 1 / 3 volume of sevage reagent, stir with a magnetic stirrer for 30 min, centrifuge at 1000 rpm for 15 min, collect the supernatant, repeat 5 times, use Membrane dialysis with a cutoff flow rate of 3500, concentrated under reduced pressure to 1 / 5 volume, adding ethanol with a mass fraction of 95% to a concentration of 30%, standing still, filtering, and then concentrating the filtrate to 1 / 5 volume. Add 95% ethanol to a concentration of 60%, let it stand for 12 hours, collect the precipitate, freeze-dry to constant weight.

Embodiment 2

[0049] A method for preparing fucoidan, comprising:

[0050] Take 80g of kelp dry powder, add 5 times the volume of ethanol with a mass fraction of 95%, ultrasonically degrease for 25 minutes, perform suction filtration under vacuum conditions, collect the filter residue, repeat 3 times, dry the filter residue, and grind through an 80-mesh sieve.

[0051] Weigh 5 g of 80-mesh kelp dry powder, add 312.5 mL of distilled water, ultrasonically treat at 65 ° C for 60 min, then add 1 / 3 volume of sevage reagent, stir with a magnetic stirrer for 30 min, centrifuge at 1000 rpm for 15 min, collect the supernatant, repeat 5 times , dialyzed with a cut-off flow rate of 3500, concentrated under reduced pressure to 1 / 5 volume, added ethanol with a mass fraction of 95% to a concentration of 30%, allowed to stand, filtered, and then concentrated the filtrate to 1 / 5 volume. Add 95% ethanol to a concentration of 60%, let it stand for 12 hours, collect the precipitate, freeze-dry to constant wei...

Embodiment 3

[0055] A preparation method of an oral liquid with hypotensive and antithrombotic effects, comprising:

[0056] Dissolution: Dissolve the prepared alginate in water to obtain a 10 mg / mL alginate solution;

[0057] Coarse filtration: remove insoluble impurities;

[0058] Flavor formulation: add 0.15% (w / w) of β-cyclodextrin, 15% (w / w) of xylitol, 0.15% (w / w) of citric acid and Appropriate amount of essence, stir evenly;

[0059] Sterilization: Sterilize with high pressure steam, sterilize at 121°C for 30min;

[0060] Filling and sealing: 20mL brown oral liquid glass bottles are used for filling, and the empty bottles and bottle caps need to be cleaned and disinfected before filling.

[0061] The prepared oral liquid kelp gum has a light fishy smell, dark brown or tan color, moderate sweet and sour taste, delicate taste, no peculiar smell, clear and transparent appearance, no visible impurities, a small amount of turbidity or precipitation is allowed, and the sensory evaluati...

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Abstract

The invention provides oral liquid capable of lowering blood pressure and resisting thrombus and belongs to the technical field of biological preparations. A preparation method of the oral liquid includes: extracting laminarin; separating and purifying fucoidan; using free radicals to degrade the fucoidan in an oxidative manner, wherein choline chloride is added during the oxidative degradation of the fucoidan; dissolving; performing rough filtration; flavoring; sterilizing; filling; sealing. The oral liquid is small in molecular weight, easy to absorb, high in sulfate radical content, high in biological activity and capable of further increasing the anti-thrombus effect of the fucoidin by improving hemorheology.

Description

technical field [0001] The invention belongs to the technical field of biological preparations, and in particular relates to an oral liquid with blood pressure lowering and antithrombotic effects. Background technique [0002] In 1913, Kylin extracted a polysaccharide containing L-fucose from kelp palmate, named Fucoidan, and the Chinese name is fucoidan, fucoidan or fucoidan. Since then, it has been reported that the molecules of fucoidan contain sulfate ester, galactose, xylose, uronic acid, etc. Fucoidan is a highly heterogeneous polysaccharide. Studies have shown that fucoidan has many biological activities, such as anticoagulant, antiviral, antithrombotic, hypotensive and antitumor functions, especially its good anticoagulant activity, which has attracted widespread attention. Anticoagulant drugs have great market potential. [0003] The amount of kelp cultured in China is in a leading position at home and abroad, and its fucoidan content reaches 3.6%, which is the br...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/737A61K47/64A61P9/12A61P7/02A61P31/12A61P35/00A61P37/04C08B37/02C08B37/00
CPCA61K9/0095A61P7/02A61P9/12A61P31/12A61P35/00A61P37/04C08B37/0003C08B37/0024C08B37/0063
Inventor 孙坤来王斌陈荫赵玉勤颜景雪刘陈楠李文思
Owner 安徽草珊瑚生物科技有限公司
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