A synthetic method of high-purity tulathromycin

A telamycin and synthesis method technology, applied in chemical instruments and methods, organic chemistry, sugar derivatives, etc., can solve the problems of multiple pathogenic factors and complicated diseases

Inactive Publication Date: 2014-06-18
QINGDAO VLAND BIOTECH INC
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

Since respiratory tract infections are generally multiple infections, with many pat...

Method used

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  • A synthetic method of high-purity tulathromycin
  • A synthetic method of high-purity tulathromycin
  • A synthetic method of high-purity tulathromycin

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Experimental program
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Embodiment

[0017] The first step: substitution reaction:

[0018] Add 58.0 kg of demethylazithromycin (I) into a 500 L reaction tank, add 300 L of chloroform and 30.7 kg of pyridine, and cool to 0°C with refrigerated brine. Add 16.1 kg of acetic anhydride within 20 minutes, and keep the temperature of the reaction solution at about 0°C during the addition. After stirring for 2 hours, the temperature was raised to room temperature, and the reaction was stirred for another 12 hours. Add 100 L of saturated sodium bicarbonate aqueous solution and 2M NaOH aqueous solution to the reaction solution to adjust the pH of the reaction solution to 9.0, stir for 10 minutes and then stand to separate the layers, and remove the lower organic phase. The organic phase was washed once each with 50 L of water and 50 L of saturated brine, then dried by adding 1 kg of anhydrous magnesium sulfate, and filtered to remove magnesium sulfate. The filtrate was concentrated under reduced pressure at 45°C, placed ...

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Abstract

The invention provides a synthetic method of high-purity tulathromycin. The method includes subjecting demethylated azithromycin adopted as a raw material to substitution, oxidation, addition, reduction, condensation, and the like, so as to obtain a target compound. According to the synthetic method, the cheaper raw material is adopted, and a traditional process employing low-temperature reaction is changed. The method has the advantages of short process route, easy-to-control reaction, high yield, and the like. The method is suitable for large-scale industrialized production.

Description

technical field [0001] The invention relates to a method for preparing a telamycin compound, which belongs to the field of veterinary medicine. Background technique [0002] Respiratory tract infection is one of the difficult-to-control infectious diseases in animal husbandry, which seriously harms animal husbandry production. When respiratory infection is prevalent, it will cause huge economic losses to livestock production. Therefore, how to prevent and treat respiratory infections in livestock such as pigs and cattle is an important research topic for veterinarians and veterinary medicine workers. Because respiratory tract infection is generally multi-infection, with many pathogenic factors and complex conditions, there is currently no very effective preventive method. For respiratory infections in animals, while seeking biological control and environmental blocking, drug control is still the main way at present. Seeking effective, safe, broad-spectrum, high-efficienc...

Claims

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Application Information

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IPC IPC(8): C07H17/00C07H1/00
Inventor 姚德勇郝智慧王艳玲
Owner QINGDAO VLAND BIOTECH INC
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