A synthetic method of high-purity tulathromycin
A telamycin and synthesis method technology, applied in chemical instruments and methods, organic chemistry, sugar derivatives, etc., can solve the problems of multiple pathogenic factors and complicated diseases
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[0017] The first step: substitution reaction:
[0018] Add 58.0 kg of demethylazithromycin (I) into a 500 L reaction tank, add 300 L of chloroform and 30.7 kg of pyridine, and cool to 0°C with refrigerated brine. Add 16.1 kg of acetic anhydride within 20 minutes, and keep the temperature of the reaction solution at about 0°C during the addition. After stirring for 2 hours, the temperature was raised to room temperature, and the reaction was stirred for another 12 hours. Add 100 L of saturated sodium bicarbonate aqueous solution and 2M NaOH aqueous solution to the reaction solution to adjust the pH of the reaction solution to 9.0, stir for 10 minutes and then stand to separate the layers, and remove the lower organic phase. The organic phase was washed once each with 50 L of water and 50 L of saturated brine, then dried by adding 1 kg of anhydrous magnesium sulfate, and filtered to remove magnesium sulfate. The filtrate was concentrated under reduced pressure at 45°C, placed ...
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