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Nanoparticles composited with upconversion nanoparticles and gold nanorods, preparation method and application thereof

A technology of nanoparticles and gold nanorods, which is applied in the field of nanobiomedicine to achieve remarkable therapeutic effects, remarkable curative effect and broad therapeutic prospects

Inactive Publication Date: 2016-04-27
CHANGCHUN INST OF OPTICS FINE MECHANICS & PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The purpose of the present invention is to solve the existing defect of using multiple excitation wavelengths in photodynamic and photothermal therapy, and to provide a composite nanoparticle of up-conversion nanoparticle and gold nanorod and its preparation method and application

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  • Nanoparticles composited with upconversion nanoparticles and gold nanorods, preparation method and application thereof
  • Nanoparticles composited with upconversion nanoparticles and gold nanorods, preparation method and application thereof

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preparation example Construction

[0022] The present invention firstly provides a preparation method of nanoparticles composited with upconversion nanoparticles and gold nanorods, comprising:

[0023] Reaction of upconverting core-shell nanoparticles with photosensitizer, and then with SiO 2 The coated gold nanorods are subjected to a coupling reaction to obtain composite nanoparticles of upconversion nanoparticles and gold nanorods; the SiO 2 The thickness of the coated gold nanorod shell is 30-60nm.

[0024] According to the present invention, the preparation method of the up-conversion core-shell nanoparticles is a method commonly used in the art, without special limitations, and the specific preparation method can refer to the literature Monodispersessilica-coatedpolyvinylpyrrolidone / NaYF 4 nanocrystalswithmulticolorupconversionfluorescenceemission, Angew.Chem.Int.Ed, 2006, 45, 7732-7735. and literature Synthesis of hexagonal-phasecore-shellNaYF 4 nanocrystalswithtunableupconversionfluorescence, Langmuir...

Embodiment 1

[0035] 1. Prepare up-conversion NaYF by high-temperature pyrolysis 4 : Yb, Er nanoparticles (reference Monodispersessilica-coatedpolyvinylpyrrolidone / NaYF 4 nanocrystalswithmulticolorupconversionfluorescenceemission, Angew.Chem.Int.Ed, 2006, 45, 7732-7735.). First, weigh the total amount of yttrium chloride YCl 3 ·6H 2 O236.8mg, ytterbium chloride YbCl 3 ·6H 2 O77.5mg, erbium chloride ErCl 3 ·6H 2 O76.3mg, weigh the quality, put it into a 50mL three-necked bottle, add 4mL oleic acid and 17mL1-octadecene. After stirring for half an hour to deoxygenate, heat up the temperature. After the medicines are dissolved, stop heating, cool to room temperature, and add 0.1gNaOH and 0.1482gNH 4 F in methanol solution, then heated up to 60°C and kept for 30min. Then keep at 75°C for 45min. The temperature was then raised to 300°C and held for 1.5 hours. After the reaction is finished, centrifuge with acetone and ethanol respectively, and the finally obtained up-conversion nanopart...

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Abstract

The invention provides nano particles compounded of up-conversion nano particles and gold nanorods and a preparation method and application of the nano particles, and belongs to the field of nano biomedicine. The method comprises the following steps: reacting up-conversion nuclear shell nano particles with a photosensitizer; and then, coupling with SiO2-coated gold nanorods to obtain the nano particles compounded of up-conversion nano particles and gold nanorods. The shell thickness of the SiO2-coated gold nanorods is 30-60nm. By means of the surface covalency or photosensitizer absorption of the up-conversion nano particles, the energy transfer efficiency is improved, so that the singlet oxygen yield is improved and the effect of photodynamics therapy is improved. Meanwhile, the acting distance betweeb the gold nanorods and the up-conversion nano particles is regulated to avoid the up-conversion fluorescence quenching phenomenon. According to the invention, upconversion and photodynamics therapy of the photosensitizer are combined with the photo-thermal effect of the SiO2-coated gold nanorods for preparing a synergic treatment nano platform. The purpose of two treatment ways are realized by one excitation light source is reached.

Description

technical field [0001] The invention belongs to the field of nano-biomedicine, and in particular relates to a nano-particle compounded with an up-conversion nano-particle and a gold nano-rod, a preparation method and an application thereof. Background technique [0002] At present, a single treatment method is used for the treatment of tumors, and its effect is not obvious. Any treatment method has its advantages and disadvantages, so it is difficult to eradicate the tumor. Therefore, multi-method synergistic treatment will be the development trend of tumor treatment. However, at this stage, synergistic therapy mainly focuses on simultaneous radiotherapy and chemotherapy, which has large invasive side effects. Photodynamic therapy and photothermal therapy are treatment methods that have come out in recent years and developed rapidly. They are effective in the treatment of many diseases, especially important malignant tumors that cause human death. They have been officially...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61K9/14A61P35/00
Inventor 常钰磊孔祥贵张友林刘晓敏涂浪平赵慧颖
Owner CHANGCHUN INST OF OPTICS FINE MECHANICS & PHYSICS CHINESE ACAD OF SCI
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