Preparation method for ZnPc-UCNP-PEG-G nano-compound

A nanocomposite, znpc-ucnp-peg-g technology, applied in the field of biomedical materials, can solve the problems of insufficient drug targeting, shallow treatment depth, etc., achieve high fluorescence resonance energy transfer efficiency, reduce side effects, and obvious target. tropic effect

Inactive Publication Date: 2017-05-10
FUZHOU UNIV
View PDF4 Cites 7 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide the preparation and application of a ZnPc-UCNP-PEG-G nanocomposite, which solves the problems of insufficient drug targeting and shallow treatment depth in photodynamic therapy

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method for ZnPc-UCNP-PEG-G nano-compound
  • Preparation method for ZnPc-UCNP-PEG-G nano-compound
  • Preparation method for ZnPc-UCNP-PEG-G nano-compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] A preparation method of ZnPc-UCNP-PEG-G nanocomposite, the specific steps are:

[0035] 1) Weigh 0.4 g NaOH into a 100 mL reactor, then measure 20 mL deionized water, 30 mL ethanol, 7.5 mL oleic acid and 4 mL n-hexane, and stir to form a uniform solution. Weigh 0.8 mmol rare earth nitrate (0.2390g Y(NO 3 )·6H 2 O, 0.1065 g Yb (NO 3 ) 5H 2 O, 0.0069 g Er(NO 3 ) 5H 2 O) Dissolve in 5 mL deionized water and drop into the above reaction solution at 20 drops / min, then weigh 0.1314 g (3.2 mmol) NaF, dissolve in 5 mL deionized water and add to the reaction solution, take out the stirring magnetic seal The device was reacted in an oven at 180 °C for 6 h. After the reaction was completed, it was naturally cooled to room temperature, extracted three times with 30 mL cyclohexane, and the cyclohexane layer was collected, which was collected by centrifugation after adding excess ethanol. Wash with deionized water and ethanol three times alternately, and finally disperse in 10...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a preparation method for a ZnPc-UCNP-PEG-G nano-compound. The preparation method comprises the following steps: synthesizing NaYF4:Yb<3+> through a micro-emulsion method; modifying Er<3+> up conversion nanoparticles with polyethylene glycol through a ligand oxidizing method to obtain water-soluble UCNP-PEG-OH; modifying a photosensitive agent and bi-carboxyl polyethylene glycol onto the surface through an EDC concentration method to a obtain ZnPc-UCNP-PEG nano-compound; lastly, loading targeted molecular gefitinib (G) modified by the polyethylene glycol onto the surface to obtain the ZnPc-UCNP-PEG-G nano-compound. The ZnPc-UCNP-PEG-G prepared by the preparation method has uniform particle distribution, high crystallization performance and high photoactivity, and can be hopefully developed into an efficient and low-toxicity novel drug loading system; the PDT therapy depth of zinc phthalocyanine and targeting ability for tumor cells can be improved.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a preparation method of a ZnPc-UCNP-PEG-G nanocomposite. Background technique [0002] Photodynamic therapy is also called photochemical therapy (Photodynamic therapy, PDT), which refers to the use of light of a specific wavelength to irradiate a drug (photosensitizer, PS) that has been injected into the body locally or systemically in advance, and the photosensitizer is then activated and reacts with oxygen molecules to produce Cytotoxic reactive oxygen species (ROS) can cause irreversible damage to tumor tissue through direct and indirect effects. Photodynamic therapy is different from traditional tumor treatment methods. It has selectivity to target tissue and damage degree, can reduce damage to normal tissue, can metabolize faster in the human body, and avoids toxicity to other parts of the body. High stability and photostability. However, traditional photodyna...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00B82Y5/00B82Y20/00A61P35/00A61K31/5377
CPCA61K31/5377A61K41/0057B82Y5/00B82Y20/00A61K2300/00
Inventor 薛金萍贾潇宋美如叶焕年
Owner FUZHOU UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap