48results about How to "Enhance photodynamic activity" patented technology

The invention discloses several non-peripherial substituted phthalocyanine metal complexes and making method, which introduces functional group into position a (position 1(4), 8(11), 15(18) and 22(25)) of phthalocyanine complex.

The invention discloses axial nucleoside asymmetrically-modified silicon phthalocyanine and a preparation method and application thereof, belonging to the preparation field of a photodynamic medicine or a photosensitizer. The axial nucleoside asymmetrically-modified silicon phthalocyanine disclosed by the invention can be applied to photodynamic treatment, photodynamic diagnosis or photodynamic disinfection as a photosensitizer, has the structural characteristic of axial asymmetric substitution, and shows good amphipathicity and excellent photodynamic activity.

The invention discloses a ruthenium complex and nanometer silver composite hydrotalcite type nanometer material and a preparation method and application thereof. The preparation method mainly comprises the following steps: firstly, intercalating the ruthenium complex between the hydrotalcite layers, and then adsorbing silver nano-particles on the surface of the hydrotalcite; the nanometer material has photodynamic activity due to the intercalated ruthenium complex, and is capable of producing active oxygen free radial after being motivated by corresponding wavelength optical for killing bacteria, and the light-emitting efficiency is further enhanced after the intercalation; the silver nano-particle loaded on the hydrotalcite surface not only has good sterilizing effect, but also can further enhance the photodynamic activity of the ruthenium complex. The nanometer material integrates multiple antibacterial organisms, has the features of high antibacterial activity, good biocompatibility and good stability. The preparation process of the material is simple, and the cost is low.

The invention discloses phthalocyanine silicon modified by amino ethyl groups and phenoxy groups as well as a preparation method and application thereof, which belong to the field of the preparation of photodynamic medicines or photosensitizers. The phthalocyanine silicon modified by the amino ethyl groups and the phenoxy groups, which is provided by the invention, can be used as a photosensitizer for photodynamic therapy, photodynamic diagnosis or photodynamic disinfection, has the advantages of definite composition, simple and convenient preparation, high photodynamic activity and the like, is easy to realize industrialization and has obvious economic and social benefits.

The invention discloses an erlotinib-phthalocyanine conjugate which targets anti-cancer molecules, and a preparation method as well as an application of the erlotinib-phthalocyanine conjugate. Through introducing erlotinib with a long alcoxyl chain into the periphery of the metal phthalocyanine large ring, the amphipathy, the biocompatibility and the targeting of photo-sensitizer can be increased. The phthalocyanine conjugate is not easy to aggregate, which is beneficial for improving cell uptake rate; meanwhile, the compound is simple in structure and is free from isomer, and the product is easy to purify accordingly. By adopting the compound, the targeting of the photo-sensitizer in photo-dynamics therapy is helpful to be enhanced, and the activity of the photo-sensitizer in photo-dynamics therapy can be enhanced at the same time. As the synthetic method provided by the invention is simple, the side reaction is small, the yield is relatively high, the raw material is easily available and the cost is low, and the preparation method is beneficial for industrial production.

The invention discloses silicon phthalocyanine modified by a cytidine derivative and a preparation method and an application thereof, which belong to the field of preparation of photodynamic medicaments or photosensitizers. The silicon phthalocyanine modified by the cytidine derivative provided by the invention can be taken as a photosensitizer for use in photodynamic therapy, photodynamic diagnosis or photodynamic disinfection, has the advantages of high selectivity, high photodynamic activity and the like, has definite constitution, is easy and convenient to prepare, and is easy to be industrialized.

The invention discloses silicon phthalocyanine axially modified by aminoethyl phenoxyl and polyethylene glycol oligomer as well as a preparation method and application of silicon phthalocyanine, belonging to the field of preparation of photodynamic medicaments or photosensitizers. The silicon phthalocyanine provided by the invention can be used as a photosensitizer for photodynamic treatment, photodynamic diagnosis or photodynamic sterilization, has the structural characteristic of axially asymmetrical substitution and shows favorable amphipathy and extremely high photodynamic activity.

The invention discloses a preparation method of a hypocrellin-transferrin targeted drug delivery system and an application of the hypocrellin-transferrin targeted drug delivery system in photodynamic therapy. The method comprises the following steps: with holo-transferrin as a carrier, inactivating the holo-transferrin by urea and beta-mercaptoethanol, and making a three-dimensional structure loose to expose Fe-ion coordination sites; adding excessive hypocrellin, coordinating with Fe coordination sites, eliminating uncombined HA and urea through dialysis, and restoring the three-dimensional structure of holo-transferrin with beta-mercaptoethanol, thereby obtaining the hypocrellin-transferrin targeted drug delivery system. The method is simple in preparation and good in application prospect; the hypocrellin-transferrin targeted drug delivery system can be prepared into freeze-dried powder for storage, and the freeze-dried powder is prepared into a preparation suitable for intravenous injection after being dissolved. Due to the tumor targeting action of holo-transferrin in the system, the photosensitive anti-tumor activity of hypocrellin can be significantly strengthened by the targeted drug delivery system.

The invention discloses a phthalocyanine metal complex containing piperazine ethyoxyl modification group and a preparing method thereof and belongs to the field of photodynamic drug preparing or photosensitizer preparing. The phthalocyanine metal complex containing piperazine ethyoxyl modification group is characterized in that the phthalocyanine metal complex has amphipathy and absorbs and sends spectrums to the wavelength position where the spectrums can pierce through human tissues in red shift mode, and photosensitizer is high in reactive oxygen production capacity. The preparing method is simple and has remarkable economic effect and social effect.

The invention discloses silicon phthalocyanine modified by an adenosine derivative and a preparation method and an application thereof, which belong to the field of preparation of photodynamic medicaments or photosensitizers. The silicon phthalocyanine modified by the adenosine derivative provided by the invention can be taken as a photosensitizer for use in photodynamic therapy, photodynamic diagnosis or photodynamic disinfection, has the advantages of high selectivity, high photodynamic activity and the like, has definite constitution, is easy and convenient to prepare, and is easy to be industrialized.

The invention provides a nanocomposite material with reinforced photodynamic activity and a preparation method thereof. The nanocomposite material is an up-converting nanocrystal @SiO2@TiO2/Au, and iscomposed of an up-converting nanocrystal, SiO2 and TiO2 shells successively coated at the periphery of the up-converting nanocrystal, and Au nanoparticles deposited on the surface of the TiO2 shell,wherein the TiO2 shell is a porous TiO2 shell composed of nanoparticles; the nanocomposite material has a particle size of 40 to 98 nm; and the particle size of the Au nanoparticles is 3.0 to 20.2 nm.The preparation method comprises the following steps: (1) coating the TiO2 shell onto a SiO2 coated up-converting nanocrystal through a controlled hydrolysis method; and (2) loading the Au nanoparticles onto the surface of TiO2 through a photochemical method. The nanocomposite material provided by the invention has the following advantages: simple and highly-efficient preparation process, uniformproduct morphology, good controllability in constitution and sizes, strong ability of generating reactive oxygen species, excellent photodynamic activity, and good application prospect in the field of photodynamic therapy.

The invention discloses a ortho-positioned bridged azacrown ether modified phthalocyanin, and a preparation method and application thereof, and belongs to the field of optically functional material preparation. The compound provided by the invention has unique ortho-positioned bridged azacrown ether modification characteristic, and is clear in structure and unique in synthesis route. The compound provided by the invention is a multifunctional molecule which can be taken as both a photosensitive drug and a metal ion spectrum probe. As the photosensitive drug, the photosensitization ability of the compound is high; and as the spectrum probe, the compound can be used for selective identification to Fe<3+> and Cu<2+> ions.

The invention discloses a thermally activated delayed fluorescent polymer and application thereof. In the general formula of the thermally activated delayed fluorescent polymer, X represents a connection mode between a benzene ring A and a benzene ring B, and the connection mode comprises that the benzene ring A and the benzene ring B are connected without X, connection is achieved by a single bond, and connection is achieved through any one of -NR1-, -O- and -S-, m+n=0.5, and m is greater than 0 and greater than 0.5. AR1 is substituted benzene, naphthalene, fluorene, carbazole, spirofluorene, anthracene and xanthene, and the substitution on the AR1 is one of a C1-C20 straight chain substituent group, a C1-C20 branched chain substituent group, a C1-C20 straight chain alkoxy group or a C1-C20 branched chain alkoxy group. According to the technical scheme, the advantages of high fluorescence quantum efficiency, relatively long emission wavelength, high photodynamic activity and the like are obtained through a simple synthesis means, and the compound can be used as an active component of a nano reagent for biomedical application.