Ruthenium complex and nanometer silver composite hydrotalcite type nanometer material and preparation method and application thereof

A technology of ruthenium complexes and nanomaterials, applied in the field of ruthenium complexes combined with nano-silver composite hydrotalcite-type nanomaterials and its preparation, can solve problems such as ineffective and slow antibacterial drug treatment

Active Publication Date: 2017-06-20
FUJIAN INST OF RES ON THE STRUCTURE OF MATTER CHINESE ACAD OF SCI
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

[0002] Pathogenic bacteria are a great threat to human health. Infectious diseases caused by pathogenic bacteria will cause more than one million deaths every year. What is more serious is that about one-third of diseases transmitted by pathogenic bacteria will Global infection or death, etc., is mainly due to the increasing resistance of pathogenic bacteria, which makes the treatment of bacteriostatic drugs slow or even ineffective

Method used

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  • Ruthenium complex and nanometer silver composite hydrotalcite type nanometer material and preparation method and application thereof
  • Ruthenium complex and nanometer silver composite hydrotalcite type nanometer material and preparation method and application thereof
  • Ruthenium complex and nanometer silver composite hydrotalcite type nanometer material and preparation method and application thereof

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Experimental program
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Effect test

Embodiment 1

[0076] The preparation of embodiment 1 Ag-Ru / LDH material

[0077] 1) Preparation of Mg-Al / LDH by co-precipitation method

[0078] Take Mg(NO 3 ) 2 ·6H 2 O (10.26g, 0.04mol), Al(NO 3 ) 3 9H 2 O (7.53g, 0.02mol) and 55mL deCO 2 Add ultrapure water into a 100mL flask, protect it with nitrogen, adjust the pH of the above mixed solution to 9 with 2M NaOH, and react at 75°C for 24h, keep the pH constant throughout the reaction process, after the reaction, centrifuge at 5000rpm for 5min The precipitate was collected, rinsed three times with ultrapure water, and then dried in vacuum at 60°C for 24 h.

[0079] 2)[Ru(H 2 dcbpy) 3 ] Cl 2 (hereinafter referred to as "Tris-Ru") preparation: under nitrogen atmosphere, 4,4'-dicarboxylic acid-2,2'-bipyridine 754mg (3.09mmol) and ruthenium trichloride trihydrate 261mg (1mmol) were dissolved in 60mL N,N-dimethylformamide (DMF), reflux at 160°C for 3h. Add 12mL of 0.5M NaOH to reflux for 4h, concentrate to 10mL, cool to room tempera...

Embodiment 2

[0089] The bactericidal activity of embodiment 2 Ag-Ru / LDH

[0090] 1. Culture medium preparation:

[0091] Luria-Bertani medium (LB medium), its formula is: 1% NaCl, 1% Tryptone, 0.5% Yeastextract.

[0092] Another double-concentration LB medium was prepared, denoted as: 2×LB, used as a dilution material, and its formula was: 2% NaCl, 2% Tryptone, 1% Yeast extract.

[0093] Prepare 1L of LB medium and 100mL of 2×LB according to the above formula, and distribute them into 10mL test tubes and 25mL Erlenmeyer flasks respectively, with 4mL in test tubes and 10mL in Erlenmeyer flasks. Sterilize at 121°C and 0.15MPa for 15 minutes, cool to room temperature, and set aside.

[0094] Second, the recovery of bacteria

[0095] Take out the frozen Escherichia coli and Staphylococcus aureus from the refrigerator at minus 80°C, put them on the ice box to thaw, take 20 μL of the bacteria solution and inoculate them into 25 mL Erlenmeyer flasks, and cultivate to the OD of the bacteria sol...

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Abstract

The invention discloses a ruthenium complex and nanometer silver composite hydrotalcite type nanometer material and a preparation method and application thereof. The preparation method mainly comprises the following steps: firstly, intercalating the ruthenium complex between the hydrotalcite layers, and then adsorbing silver nano-particles on the surface of the hydrotalcite; the nanometer material has photodynamic activity due to the intercalated ruthenium complex, and is capable of producing active oxygen free radial after being motivated by corresponding wavelength optical for killing bacteria, and the light-emitting efficiency is further enhanced after the intercalation; the silver nano-particle loaded on the hydrotalcite surface not only has good sterilizing effect, but also can further enhance the photodynamic activity of the ruthenium complex. The nanometer material integrates multiple antibacterial organisms, has the features of high antibacterial activity, good biocompatibility and good stability. The preparation process of the material is simple, and the cost is low.

Description

technical field [0001] The invention relates to the technical field of photodynamic bacteriostasis, in particular to a ruthenium complex combined with nano-silver composite hydrotalcite nanomaterial and its preparation method and application. Background technique [0002] Pathogenic bacteria are a great threat to human health. Infectious diseases caused by pathogenic bacteria will cause more than one million deaths every year. What is more serious is that about one-third of diseases transmitted by pathogenic bacteria will The occurrence of global infection or death is mainly due to the increasing drug resistance of pathogenic bacteria, which makes the treatment of bacteriostatic drugs slow or even ineffective. Therefore, the development of new antibacterial agents is necessary, and the emergence of these new agents may change the traditional antibacterial mode. In the past decades, many antibacterial nanomaterials have been extensively studied, and their antibacterial mecha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N59/16A01N55/02A01P1/00A01P3/00
CPCA01N55/02A01N59/16A01N2300/00
Inventor 吴允昆刘晓林肖方南肖越赵艳和陈方满
Owner FUJIAN INST OF RES ON THE STRUCTURE OF MATTER CHINESE ACAD OF SCI
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