Phthalocyanine-temperature sensitive gel preparation and preparation method thereof

Abstract

The invention belongs to the field of pharmaceutical preparations or photodynamic medicines, and particularly relates to a phthalocyanine-temperature sensitive gel preparation and a preparation methodthereof. The phthalocyanine-temperature sensitive gel preparation is prepared from 19-23 wt% of poloxamer 407, 1.1-1.7 wt% of poloxamer 188, 0.001-1 wt% of phthalocyanine and the balance water and organic solvents. The temperature sensitive gel preparation has the advantages that gel is changed into a solid quickly when the temperature reaches 29-31 DEG C, the medicine can be attached to the surface of the skin and serve as a local medicine dosage form for the skin, application is convenient, and medicine liquid is not easily lost. The phthalocyanine-temperature sensitive gel preparation canserve as a photosensitive medicament for treating tinea unguium and tinea pedis and has significant clinical application value.

Description

technical field

[0001] The invention belongs to the field of pharmaceutical preparations or photodynamic drugs, and in particular relates to a photosensitizer-thermosensitive gel preparation and a preparation method thereof. Background technique

[0002] Photodynamic therapy (or photodynamic therapy), in essence, is the application of the photosensitization reaction of photosensitizers (or photosensitizers) in the medical field. The process of action is to first inject the photosensitizer into the body, and after a period of time (this waiting time is to allow the drug to be relatively enriched in the target body), the target body is irradiated with light of a specific wavelength (for the target in the body cavity, the target body can be irradiated with the help of optical fiber). The photosensitizer enriched in the target stimulates a series of photophysical and photochemical reactions under light excitation to generate active oxygen and destroy the target. Photodynamic th...

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