A kind of phthalocyanine-thermosensitive gel preparation and preparation method thereof

Abstract

The invention belongs to the field of pharmaceutical preparations or photodynamic drugs, and in particular relates to a phthalocyanine-thermosensitive gel preparation and a preparation method thereof. The composition of the phthalocyanine-thermosensitive gel preparation is: 19-23wt% poloxamer 407, 1.1-1.7wt% poloxamer 188, 0.001-1wt% phthalocyanine, and the balance is water and organic solvent. The temperature-sensitive gel preparation quickly turns the gel into a solid when the temperature reaches 29-31°C, so that the drug can adhere to the skin surface. As a topical dosage form for skin, it has the advantages of easy application and difficult loss of drug solution. The phthalocyanine-thermosensitive gel preparation can be used as a photosensitizer for treating onychomycosis and athlete's foot, and has significant clinical application value.

Description

technical field

[0001] The invention belongs to the field of pharmaceutical preparations or photodynamic drugs, and in particular relates to a photosensitizer-thermosensitive gel preparation and a preparation method thereof. Background technique

[0002] Photodynamic therapy (or photodynamic therapy), in essence, is the application of the photosensitization reaction of photosensitizers (or photosensitizers) in the medical field. The process of action is to first inject the photosensitizer into the body, and after a period of time (this waiting time is to allow the drug to be relatively enriched in the target body), the target body is irradiated with light of a specific wavelength (for the target in the body cavity, the target body can be irradiated with the help of optical fiber). The photosensitizer enriched in the target stimulates a series of photophysical and photochemical reactions under light excitation to generate active oxygen and destroy the target. Photodynamic th...

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