52results about How to "High molar absorption coefficient" patented technology

An axially substituted silicon-phthalocyanin match and its composition are disclosed, which have high optical spectrum characteristics and can be used as the photosensitizer used for photodynamic therapy to tumor and the diseases other than cancer, photodynamic diagnosis and photodynamic disinfecting.

The invention relates to a preparation method, a raw material, a product and an application of an optical coupling crosslinking hydrogel material. Component A-nitrobenzyl phototrigger modified high-molecular derivatives are dissolved in a medium with biological compatibility in order to obtain a solution A; component B-primary amine, diamine, hydrazide, hydroxylamine high-molecular derivatives aredissolved in a medium with biological compatibility in order to obtain a solution B; the solution A and the solution B are uniformly mixed in order to obtain a hydrogel precursor solution; the hydrogel precursor solution is under light source irradiation, aldehyde group or ketone group generated by nitrobenzyl in the component A and primary amine, diamine, hydrazide, hydroxylamine groups in the component B are crosslinked in form of Schiff base in order to form a hydrogel. The invention also provides a kit for preparation of the hydrogel, and applications of the hydrogel to tissue engineering, regenerative medicine, 3D printing, and carriers of cells, proteins or drugs. The hydrogel precursor solution is sprayed or smeared on the surface of tissue in order to realize in situ gelation under light, and the product is especially suitable for postoperative wound enclosing and tissue fluid leakage sealing.

The invention discloses several non-peripherial substituted phthalocyanine metal complexes and making method, which introduces functional group into position a (position 1(4), 8(11), 15(18) and 22(25)) of phthalocyanine complex.

The present invention provides several application of non-peripheral substituted phthalocyanine metal coordination compound. The invented phthalocyanine metal coordination compound has the application for preparing photosensitive medicine preparation which can be used in photodynamic therapy or photodynamic diagnosis, and has the application for preparing photosensitizer which can be used in photodynamic purification or disinfection. Besides, it can be used as fluorescence probe or can be used for determining protein content.

The invention discloses a phthalocyanine metal complex as well as a preparation method and an application of the phthalocyanine metal complex. 3-[2,4,6-tri(dimethylamino methyl)-phenoxyl] phthalonitrile is prepared by using 2-phthalonitrile nitryl and 2,4,6-tri(dimethylamino methyl)-phenol as reactants, and further, the phthalocyanine metal complex substituted with amido or amido alpha bit is prepared. The phthalocyanine metal complex has the characteristics of high photosensitive activity and high water solubility; the phthalocyanine metal complex exists in water in a monomer mode, so that the photodynamic activity is facilitated in the water; the phthalocyanine metal complex is subjected to absorption spectroscopic redshift and shifted to a near-infrared area where is beneficial for penetrating through human tissues. The phthalocyanine metal complex is specially high in photodynamic antifungal activity and can be used for preparing photosensitizers or photodynamic medicines or photosensitive medicaments.

The present invention relates to a novel dye compound, represented by the following formula (I):wherein R1, D1, D2, X, and Y are defined the same as the specification. The dye compound of the present invention is suitable for Dye-Sensitized Solar Cell (DSSC). In addition, the dye compound of the present invention has high molar absorption coefficient, so that the DSSC manufactured by the dye compound of the present invention can have good photoelectric characteristics.

The present invention relates to a dye compound represented by the following formula (I), or a salt thereof:wherein R1, R2, R3, R4, D1, D2, B, and n are defined the same as the specification, and also relates to a photoelectric component using the same. The dye compound of the present invention is suitable for Dye-Sensitized Solar Cell (DSSC). Hence, the photoelectric characteristics of the DSSC can be improved by using the dye compound of the present invention.

The invention discloses phthalocyanine silicon modified by amino ethyl groups and phenoxy groups as well as a preparation method and application thereof, which belong to the field of the preparation of photodynamic medicines or photosensitizers. The phthalocyanine silicon modified by the amino ethyl groups and the phenoxy groups, which is provided by the invention, can be used as a photosensitizer for photodynamic therapy, photodynamic diagnosis or photodynamic disinfection, has the advantages of definite composition, simple and convenient preparation, high photodynamic activity and the like, is easy to realize industrialization and has obvious economic and social benefits.

The invention discloses a method for measuring organic acid content based on precolumn derivatization LC-MS, and belongs to the field of analytical chemistry.The method comprises the steps that 1, a sample to be tested, sodium carbonate and 2-bromoacetophenone are added to a solvent, a derivatization reaction is carried out for 20 h to 28 h at the temperature of 50 DEG C to 60 DEG C after even mixing, and the product is cooled for use; 2, the reaction product in the step 1 is taken for liquid chromatogram-mass spectrum analysis, and the content of organic acid in the sample to be detected is calculated by referring to a standard curve.A chemical modification technology is adopted for derivatization of the organic acid, the physicochemical characteristic of the organic acid is changed, the ionization efficiency can be improved in hygroplasm combined detection, matrix interference can be reduced, meanwhile, interference of inorganic salt and endogenous impurities is reduced, the signal strength ofanalyte is improved, and chromatographic separation and mass spectrometric detection are convenient; then a liquid chromatogram-mass spectrum combined technology is adopted for analyzing and detecting the derivatization product, qualitative and quantitative analysis on the organic acid can be achieved, and the advantages of being simple, efficient, high in detecting sensitivity, good in accuracy and the like are achieved.

The invention discloses an organic photoelectric detector responded by a broadband spectrum. The detector comprises a substrate, a transparent conductive layer, an anode modifying layer, a photosensitive layer, a hole blocking layer and a cathode layer which are sequentially stacked, wherein the thickness of the transparent conductive layer is 100-150 nanometers, the thickness of the anode modifying layer is 35-50 nanometers, the thickness of the photosensitive layer is 100-240 nanometers, the thickness of the hole blocking layer is 35-50 nanometers, the thickness of the cathode layer is 80-120 nanometers, the transparent conductive layer is made of a conductive material, the anode modifying layer is made of a P-type semiconductor material, the photosensitive layer is made of a mixture containing an organic polymer donor material, a micromolecule donor material and an acceptor material, the hole blocking layer is made of an N-type semiconductor material, and the cathode layer is made of a low-work-content metal material; the device structure and manufacturing technology are simple, the light response range of the photosensitive layer is enlarged, the response degree of light signals to be detected can be remarkably increased, and the detector has the large advantage, is not sensitive to temperature, has multiple application scenes and is convenient to popularize.

The invention discloses a silicon phthalocyanine axially bonded with a piperidine or morpholine derivative with an ester bond as well as a preparation method and application of the silicon phthalocyanine and belongs to the field of preparing photodynamic drugs or photosensitizers. The silicon phthalocyanine can be used as a photosensitizer used for carrying out photodynamic antibacterium, photodynamic cancer resistance, photodynamically treating other diseases, photodynamic disinfection and photodynamic diagnosis and has the advantages of simple preparation, strong photosensitization and the like, and the maximum absorption spectrum is located in a near infrared region.

The invention discloses silicon phthalocyanine axially modified by aminoethyl phenoxyl and polyethylene glycol oligomer as well as a preparation method and application of silicon phthalocyanine, belonging to the field of preparation of photodynamic medicaments or photosensitizers. The silicon phthalocyanine provided by the invention can be used as a photosensitizer for photodynamic treatment, photodynamic diagnosis or photodynamic sterilization, has the structural characteristic of axially asymmetrical substitution and shows favorable amphipathy and extremely high photodynamic activity.

The invention provides a benzo disulfoxide thienyl polymer, and the polymer has sulfonyl groups with strong electron-withdrawing power, can form a receptor material when bonded with other groups with the electron-withdrawing characteristic, has excellent electric charge transmission performance and can widen the absorption of a material in a visible light region. The material has a simple preparation method and can be used in receptor materials of solar batteries for improving the efficiency of battery devices.

To provide a near-IR absorption compound free from antimony or arsenic and excellent in stability, especially, in heat resistance, light fastness, and moisture-and-heat resistance and also an IR absorption filter, an optical information recording medium, and a resin composition excellent in durability by using the near-IR absorption compound. The near-IR absorption compound is a diimmonium compound having the following structure and the resin composition contains the diimmonium compound: (wherein R 1 to R 8 independently denote hydrogen atom or an optionally substituted aliphatic hydrocarbon group; R 9 and R 10 independently denote an aliphatic hydrocarbon group optionally containing a halogen atom; and rings A and B may further have substituent groups.).

The invention provides a Schiff base fluorescent polymer with a structure shown in a formula I and a preparation method thereof. The preparation method comprises the following steps: reducing 4-nitro polystyrene into 4-amino polystyrene, reacting 4,4-biformyl triphenylamine with 1,10-phenanthroline-5,6-diketone to synthesize a small molecule fluorescent compound II, and finally, carrying out a Schiff base reaction between the small molecule fluorescent compound II and the 4-amino polystyrene, cooling, washing and drying to prepare the Schiff base fluorescent polymer. The Schiff base fluorescent polymer can have high identification performance to DNA and metal ions and can be used as a polymer type fluorescence probe. (img file='DDA0000454216050000011.TIF' wi='1128' he='952' / ).

The invention discloses a phthalocyanine metal complex containing piperazine ethyoxyl modification group and a preparing method thereof and belongs to the field of photodynamic drug preparing or photosensitizer preparing. The phthalocyanine metal complex containing piperazine ethyoxyl modification group is characterized in that the phthalocyanine metal complex has amphipathy and absorbs and sends spectrums to the wavelength position where the spectrums can pierce through human tissues in red shift mode, and photosensitizer is high in reactive oxygen production capacity. The preparing method is simple and has remarkable economic effect and social effect.

The invention provides a benzodisulfone thienyl polymer which is provided with a sulfone group with a strong electron-withdrawing ability, and the sulfone group can be connected with other groups with an electron-withdrawing property to form a receptor material which has excellent charge transportation performance and can broaden absorption of materials in a visible region. A preparation method of the material provided by the invention is simple and feasible, and can be used for a receptor material of an organic solar cell to improve the efficiency of a cell device.

The invention provides a polymer or a micro-molecular material having a molecular main chain comprising a benzophene group, which has sulfonyl group having strong electron-withdrawing capability, can form a donor material by connecting with other groups having donor characteristic, has excellent charge transmission performance, and can widen absorption of the material in a visible light zone. The preparation method of the material is easy to carry out, the material can be used for the donor material of an organic solar cell, and can increase the efficiency of a cell device.

The invention discloses silicon phthalocyanine axially modified by aminoethyl phenoxyl and polyethylene glycol oligomer as well as a preparation method and application of silicon phthalocyanine, belonging to the field of preparation of photodynamic medicaments or photosensitizers. The silicon phthalocyanine provided by the invention can be used as a photosensitizer for photodynamic treatment, photodynamic diagnosis or photodynamic sterilization, has the structural characteristic of axially asymmetrical substitution and shows favorable amphipathy and extremely high photodynamic activity.

The invention discloses a phthalocyanine metal complex as well as a preparation method and an application of the phthalocyanine metal complex. 3-[2,4,6-tri(dimethylamino methyl)-phenoxyl] phthalonitrile is prepared by using 2-phthalonitrile nitryl and 2,4,6-tri(dimethylamino methyl)-phenol as reactants, and further, the phthalocyanine metal complex substituted with amido or amido alpha bit is prepared. The phthalocyanine metal complex has the characteristics of high photosensitive activity and high water solubility; the phthalocyanine metal complex exists in water in a monomer mode, so that the photodynamic activity is facilitated in the water; the phthalocyanine metal complex is subjected to absorption spectroscopic redshift and shifted to a near-infrared area where is beneficial for penetrating through human tissues. The phthalocyanine metal complex is specially high in photodynamic antifungal activity and can be used for preparing photosensitizers or photodynamic medicines or photosensitive medicaments.

The invention discloses a preparation method of photosensitizer-doped nanoparticles with fluorescence resonance energy transfer and antenna effects and used for photodynamic therapy. The method comprises the following steps: 1) preparing a certain concentration of organic solvent solution A of porphyins; 2) preparing a certain concentration of organic solvent solution B of perylene or pyrene; 3) according to certain doping proportion, mixing the solution A and the solution B to obtain a solution C; and 4) dropwise adding a certain amount of solution C into water, severely stirring to obtain a final solution D, namely a nanoparticle-containing aqueous solution. The preparation method is simple and feasible, and excellent nanoparticles integrating diagnosis and treatment can be prepared and applied for cancer therapy.

The invention discloses a pericyclic monosubstituted amphiphilic phthalocyanine photosensitive agent as well as preparation and application thereof, which belongs to the field of preparation of photodynamic drugs or photosensitive agents. A compound of the invention has the characteristics that the amphipathy is realized, the structure is clear, nano particles which can be assembled into a quenching state in a physiological solution is realized, but the nano particles can be activated by albumin, and the pericyclic monosubstituted amphiphilic phthalocyanine photosensitive agent is an activatable targeting photosensitive agent.

The invention discloses a ortho-positioned bridged azacrown ether modified phthalocyanin, and a preparation method and application thereof, and belongs to the field of optically functional material preparation. The compound provided by the invention has unique ortho-positioned bridged azacrown ether modification characteristic, and is clear in structure and unique in synthesis route. The compound provided by the invention is a multifunctional molecule which can be taken as both a photosensitive drug and a metal ion spectrum probe. As the photosensitive drug, the photosensitization ability of the compound is high; and as the spectrum probe, the compound can be used for selective identification to Fe<3+> and Cu<2+> ions.

The invention relates to a preparation method, a raw material, a product and an application of an optical coupling crosslinking hydrogel material. Component A-nitrobenzyl phototrigger modified high-molecular derivatives are dissolved in a medium with biological compatibility in order to obtain a solution A; component B-primary amine, diamine, hydrazide, hydroxylamine high-molecular derivatives aredissolved in a medium with biological compatibility in order to obtain a solution B; the solution A and the solution B are uniformly mixed in order to obtain a hydrogel precursor solution; the hydrogel precursor solution is under light source irradiation, aldehyde group or ketone group generated by nitrobenzyl in the component A and primary amine, diamine, hydrazide, hydroxylamine groups in the component B are crosslinked in form of Schiff base in order to form a hydrogel. The invention also provides a kit for preparation of the hydrogel, and applications of the hydrogel to tissue engineering, regenerative medicine, 3D printing, and carriers of cells, proteins or drugs. The hydrogel precursor solution is sprayed or smeared on the surface of tissue in order to realize in situ gelation under light, and the product is especially suitable for postoperative wound enclosing and tissue fluid leakage sealing.

The invention provides a polymer or a micro-molecular material having a molecular main chain comprising a dibenzothiophene sulfoxide group, which has sulfonyl group having strong electron-withdrawing capability, can form a donor material by connecting with other groups having donor characteristic, has excellent charge transmission performance, and can widen absorption of the material in a visible light zone. The preparation method of the material is easy to carry out, the material can be used for the donor material of an organic solar cell, and can increase the efficiency of a cell device.

The invention discloses a silicon phthalocyanine axially bonded with a piperidine or morpholine derivative with an ester bond as well as a preparation method and application of the silicon phthalocyanine and belongs to the field of preparing photodynamic drugs or photosensitizers. The silicon phthalocyanine can be used as a photosensitizer used for carrying out photodynamic antibacterium, photodynamic cancer resistance, photodynamically treating other diseases, photodynamic disinfection and photodynamic diagnosis and has the advantages of simple preparation, strong photosensitization and the like, and the maximum absorption spectrum is located in a near infrared region.

The invention discloses several non-peripherial substituted phthalocyanine metal complexes and making method, which introduces functional group into position a (position 1(4), 8(11), 15(18) and 22(25)) of phthalocyanine complex.

The invention discloses a novel condensed heteroaromatic ring organic light-emitting material, the structure of which is 11-(diethylamino)benzo[g]benzo[4,5]imidazo[1,2-a][1, 8] Naphthyridine-6-carbonitrile (NBC). This material is prepared by one-pot method using 2-chloro-7-(diethylamino)quinoline-3-formaldehyde and 2-cyanomethylbenzimidazole as raw materials. In solution, NBC has large molar absorption coefficient, high fluorescence quantum yield, and large stokes shift value. It is sensitive to solvent, environmental pH, and viscosity. It can be used as a pH and viscosity probe to measure pH and solution viscosity in real time and quickly. In the solid state, the emission wavelength of NBC is in the near-infrared region, and the luminous efficiency is high. NBC has good luminescence properties in both solution and solid state, and the dual-efficiency organic materials realize the multi-functionalization of applications.