44results about How to "Good spectral properties" patented technology

An axially substituted silicon-phthalocyanin match and its composition are disclosed, which have high optical spectrum characteristics and can be used as the photosensitizer used for photodynamic therapy to tumor and the diseases other than cancer, photodynamic diagnosis and photodynamic disinfecting.

The invention discloses several non-peripherial substituted phthalocyanine metal complexes and making method, which introduces functional group into position a (position 1(4), 8(11), 15(18) and 22(25)) of phthalocyanine complex.

The invention relates to a method for preparing a Y2O3:Tb<3+>@SiO2-NH2 fluorescence sensor array used for detecting an organic chlorine pesticide. The marking recognition sites in the fluorescence sensor array are mutually effected with organic chlorine pesticide molecules (target molecules), the target molecules and Tb<3+> on the recognition sites form an organic ligand through coordination, and change of the fluorescence intensity of Tb<3+> is used for detecting the target molecules. The method comprises the following three steps: preparing Y2O3:Tb<3+> fluorescent powder, then synthesizing a Y2O3:Tb<3+>@SiO2-NH2 fluorescence probe having capability for identifying the marking target molecules, finally, through a micromachining technology and a plasma etching method, dropping the fluid suspension of the fluorescence probe having the capability for identifying the marking target molecules on a silicon chip, naturally drying the silicon chip, and spontaneously putting the fluorescence probe materials in a micro hole to obtain the fluorescence sensor array for high-selectivity identification and high sensitive signal detection on the target molecules.

The invention discloses a synthesis method of near infrared silver sulfide quantum dots, belonging to the technical field of functional nanomaterials. The synthesis method comprises the following steps: (1) dissolving silver nitrate crystals into a polar solvent ethylene glycol, stirring at a dark place being 3 DEG C-5 DEG C until dissolving is achieved, so as to obtain a solution A; (2) under the stirring state, adding a mercaptan carboxylic acid solution to obtain a solution B; (3) placing the solution B under the condition of 70 DEG C to 80 DEG C and stirring at a dark place, reacting for 2min to 8min, so as to lead the solution B to gradually become milk white from colorless and gradually form silver sulfide crystal nucleus; (4) increasing the reaction temperature to 140 DEG C to 150 DEG C from 70 DEG C to 80 DEG C, continuously reacting, to gradually transform the milk white solution B into clear brown solution B, and form stable silver sulfide crystal nucleus; (5) rapidly cooling to room temperature and stopping reaction; and (6) ultrafiltering to remove the solvent and reaction side products, adding water for washing and dispersing, to obtain silver sulfide quantum dots. The method is simple and highly efficient, and can conduct mass production, the synthesized quantum dots are good in water phase dispersity, scattered and uniform in particle size and stable in optical property.

The invention belongs to the field of research and development of HIV inhibitors, and discloses a preparation method for a terpyridine pyridinium (II) complex and application thereof in HIV reverse transcriptase inhibition. The structure of a cationic moiety of the terpyridine pyridinium (II) complex is as shown in a formula I. A preparation process for the terpyridine pyridinium (II) complex is optimized, the raw material cost is low, and the reaction time is short. The obtained complex is high in purity and yield and has good water solubility and excellent spectral properties. The terpyridine pyridinium (II) complex has the capability of selective binding to a TAR region on HIV RNA, and can block the reverse transcription process of viral RNA by reverse transcriptase and inhibit the replication of viral RNA. The terpyridine pyridinium (II) complex is a highly affinitive HIV RNA selective binding reagent and a highly active HIV reverse transcriptase inhibitor, and is an HIV drug having a great application potential.

The invention discloses axial nucleoside asymmetrically-modified silicon phthalocyanine and a preparation method and application thereof, belonging to the preparation field of a photodynamic medicine or a photosensitizer. The axial nucleoside asymmetrically-modified silicon phthalocyanine disclosed by the invention can be applied to photodynamic treatment, photodynamic diagnosis or photodynamic disinfection as a photosensitizer, has the structural characteristic of axial asymmetric substitution, and shows good amphipathicity and excellent photodynamic activity.

The invention discloses phthalocyanine silicon modified by amino ethyl groups and phenoxy groups as well as a preparation method and application thereof, which belong to the field of the preparation of photodynamic medicines or photosensitizers. The phthalocyanine silicon modified by the amino ethyl groups and the phenoxy groups, which is provided by the invention, can be used as a photosensitizer for photodynamic therapy, photodynamic diagnosis or photodynamic disinfection, has the advantages of definite composition, simple and convenient preparation, high photodynamic activity and the like, is easy to realize industrialization and has obvious economic and social benefits.

The invention discloses silicon phthalocyanine axially modified by aminoethyl phenoxyl and polyethylene glycol oligomer as well as a preparation method and application of silicon phthalocyanine, belonging to the field of preparation of photodynamic medicaments or photosensitizers. The silicon phthalocyanine provided by the invention can be used as a photosensitizer for photodynamic treatment, photodynamic diagnosis or photodynamic sterilization, has the structural characteristic of axially asymmetrical substitution and shows favorable amphipathy and extremely high photodynamic activity.

The invention discloses a phthalocyanine metal complex containing piperazine ethyoxyl modification group and a preparing method thereof and belongs to the field of photodynamic drug preparing or photosensitizer preparing. The phthalocyanine metal complex containing piperazine ethyoxyl modification group is characterized in that the phthalocyanine metal complex has amphipathy and absorbs and sends spectrums to the wavelength position where the spectrums can pierce through human tissues in red shift mode, and photosensitizer is high in reactive oxygen production capacity. The preparing method is simple and has remarkable economic effect and social effect.

The invention discloses a phthalocyanine metal complex as well as a preparation method and an application of the phthalocyanine metal complex. 3-[2,4,6-tri(dimethylamino methyl)-phenoxyl] phthalonitrile is prepared by using 2-phthalonitrile nitryl and 2,4,6-tri(dimethylamino methyl)-phenol as reactants, and further, the phthalocyanine metal complex substituted with amido or amido alpha bit is prepared. The phthalocyanine metal complex has the characteristics of high photosensitive activity and high water solubility; the phthalocyanine metal complex exists in water in a monomer mode, so that the photodynamic activity is facilitated in the water; the phthalocyanine metal complex is subjected to absorption spectroscopic redshift and shifted to a near-infrared area where is beneficial for penetrating through human tissues. The phthalocyanine metal complex is specially high in photodynamic antifungal activity and can be used for preparing photosensitizers or photodynamic medicines or photosensitive medicaments.

The invention relates to the technical field of organic chemical industry and fine chemical engineering, and provides an organosilicon group-modified fluorine-boron dipyrrole fluorochrome and a preparation method and an application thereof, which solve all problems of a modification system based on carbon chemistry. Under inert gas protection, iodo BODIPY and silane-containing hydrogen are taken as the raw materials, under alkaline condition, the raw materials are subjected to a catalytic reaction for 24-72 hours in a solvent at room temperature, and the material is separated through silica-gel column chromatography to prepare the organosilicon group-modified fluorine-boron dipyrrole fluorochrome. The organosilicon group-modified fluorine-boron dipyrrole fluorochrome has excellent spectrum properties such as high molar extinction coefficient and high fluorescence quantum yield, can greatly increase the light stability, and is the ideal light functional material.

The invention discloses a pericyclic monosubstituted amphiphilic phthalocyanine photosensitive agent as well as preparation and application thereof, which belongs to the field of preparation of photodynamic drugs or photosensitive agents. A compound of the invention has the characteristics that the amphipathy is realized, the structure is clear, nano particles which can be assembled into a quenching state in a physiological solution is realized, but the nano particles can be activated by albumin, and the pericyclic monosubstituted amphiphilic phthalocyanine photosensitive agent is an activatable targeting photosensitive agent.

The invention discloses a method for processing a special saddle point problem, which converts an original linear system into an equivalent linear system easy to solve and enables a preprocessing matrix P-1A to be provided with better spectral properties than an original matrix, so that the convergence speed of the algorithm is increased, and the calculation efficiency of the algorithm is improved; and the shielding effect is improved, the external interference is reduced, and data errors are prevented.