Preparation method of hypocrellin-transferrin targeted drug delivery system and application of hypocrellin-transferrin targeted drug delivery system in photodynamic therapy
A technology of Bamboo Rhododendron A and transferrin, applied in the field of photosensitizers, can solve the problems of affecting the conformation and activity of transferrin, affecting the drug release process, disintegration of the drug delivery system, etc., and achieves good dispersibility and water solubility. The effect of high, stable dispersion properties
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[0026] Example 1
[0027] A preparation method of a rhododendron A targeted drug delivery system, using all-iron transferrin to prepare a rhododendron A-transferrin chelate, the method is as follows:
[0028] In a physiological buffer solution, use urea and β-mercaptoethanol to inactivate all-ferritransferrin to make its three-dimensional structure loose and expose the Fe ion coordination site, then add excess rhododendron A (according to HA and Tf according to 2 : 1 ratio), shake at a constant temperature for 24h at 4°C, remove unbound HA, urea, and β-mercaptoethanol by dialysis to reduce the three-dimensional structure of whole iron transferrin, and obtain Bamboo Rhododendron A-transferrin targeted drug delivery system, the samples were freeze-dried to obtain freeze-dried powder, which was dissolved in purified water before use.
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