30results about How to "Has a targeting function" patented technology

A fluorescently-labeled hydrophobic modified oligochitose polymer used for preparing target medicine or fluorescent signal amplifier carrier is prepared through reaction between aqueous solution of oligochitose, fatty acid and cross-linking coupler, and reacting on isothiocyano fluorescent larbel in ice bath, darc and magnetic stirring conditions to obtain said polymer, and ultrasonically dispersing it in water to obtain its colloidal microparticles.

The invention discloses an alimentary resistant starch, the process for preparing the starch, and the use of the starch in preparing oral administration colon targeting medicament control release vectors, wherein the starch preparing process comprises the steps of, (1) mixing the starch with water, (2) heavy pressure modifying the starch or starch milk, (3) reacting in a reactor, (4) subjecting the enzymolysis product yield to centrifugation, scouring, filtering, drying and disintegration.

Hydrophobic nanoparticles have great potential in biological analysis and biomedical application. The invention provides a simple method; a DNA nanostructure is used as a phase transition reagent; the DNA nanostructure is a DNA tetrahedral structure formed by self-assembly of four single-stranded DNAs, tail ends of three single-stranded DNAs of the four single-stranded DNAs are modified by carboxyl, the other one single-stranded DNA contains an aptamer, and the aptamer can be specifically combined with highly expressed nucleolin on a cancer cell membrane surface, so that the targeting ability of the nanoparticles is increased and the cell uptake ability is improved. The DNA tetrahedron as the phase transition reagent is non-toxic and convenient and only requires simple separation, and the high-stability and good-dispersion hydrophilic nanoparticles can be prepared.

The invention relates to a tumor-targeted hollow core-shell structure nano diagnosis-treatment agent and a preparation method thereof. The nano diagnosis-treatment agent comprises an upconversion nanoparticle inner core, an organic-inorganic hybrid silica shell layer and an intermediate cavity structure, can improve the load capacity of a photosensitizer and reduce the photosensitizer aggregation, and can specifically recognize cancer cells by connecting tumor-targeted molecules (such as urokinase ammonia terminal fragments) to the surface; under the irradiation of 980 nm laser, a visible light emission sensitizing photosensitizer of the nano diagnosis-treatment agent generates singlet oxygen, so that the photodynamic therapy of cancer cells can be performed; in addition, the nano diagnosis-treatment agent can be used for the upconversion luminescence and CT dual-mode imaging by utilizing the upconversion luminescence and strong X-ray absorption characteristics.

The invention discloses a preparation method and application of an RGD@BBN double-targeted MR (magnetic resonance)/optical dual-mode molecular probe, wherein the RGD@BBN double-targeted MR/optical dual-mode molecular probe is prepared by the following steps: coating water-soluble superparamagnetic iron oxide ( SPIO) particles in hydrophilic core of lipidosome and coating oil-soluble QDs particles in hydrophobic lipid bilayer of the lipidosome by taking lipidosome as a carrier, and linking a double-targeted RGD@BBN ligand by virtue of a post-interpolation method. The RGD@BBN contained in the dual-mode molecular probe disclosed by the invention is interpolated and immobilized on the surface of the lipid bilayer by virtue of self-assembly, and the preparation method is mild in condition and is efficient and practical. According to the invention, a relatively independent space is coated by two different image contrast agents without changing the properties of the image contrast agents; and the prepared double-target dual-mode molecular probe, which simultaneously has RGD and BBN targeting functions, has targeting functions on RGD or (and) BBN receptor-positive tumors.

The invention discloses a protein nanoparticle containing a bioactivity oligopeptide-ferritin heavy chain subunit and a preparation method of the protein nanoparticle. The preparation method comprises the following steps: amplifying a fragment of a fusion gene of the bioactivity oligopeptide-ferritin heavy chain subunit by adopting an overlapping PCR (polymerase chain reaction) technology, inserting the amplified fragments into a pET28a(+) carrier, and transforming the carrier into a DH5 alpha competent cell to obtain expression engineering bacteria and an inclusion body; uniformly mixing the diluted bioactivity oligopeptide-ferritin heavy chain subunit inclusion body and an EGF (epidermal growth factor)-ferritin heavy chain subunit inclusion body according to a molar ratio of 6:4, and performing dialysis and renaturation on the uniformly mixed solution in a dialysis bag to obtain the multi-functionalized protein nanoparticle containing the bioactivity oligopeptide-ferritin heavy chain subunit. The obtained protein nanoparticle has a targeting function and also has spacing and stabilizing effects on modification of bioactivity oligopeptides; the interaction among oligopeptides is avoided, so that the functionalization of the protein nanoparticle is made possible.

The invention discloses a multifunctional probe and a preparation method and application thereof. The nano diagnosis and treatment probe with the two functions of magnetic resonance imaging and thermal therapy is formed in the mode that nano gold bars are formed by adding surfactant, chloroauric acid, a reduction agent and silver nitrate, target macromolecules are inoculated, and gadolinium ions are adsorbed. The preparation method is simple, the probe is good in dispersity in an aqueous solution, good in stability and capable of meeting requirements of clinical application and combining radiography and thermal therapy, and the dual functions of lymphoma diagnosis and treatment are achieved.

The invention discloses an anti-microbial lipopenic compound with a target function and a preparation method thereof. The anti-microbial lipopenic compound is prepared from lipopeptid and neoglycolipid which are self assembled in solution, wherein the lipopeptid and the neoglycolipid are similar in structure, the lipopeptid is prepared from bioactive peptide and a hydrophobic chain section, and the neoglycolipid is prepared from oligosaccharide and a similar hydrophobic chain section. According to the anti-microbial lipopenic compound with the target function, a glycosyl unit in the neoglycolipid is utilized as a chemotactic agent to target bacterial membranes, and the anti-microbial lipopeptid plays an anti-microbial role; thus, the anti-microbial lipopenic compound has the characteristics of being high in anti-microbial activity, long in action time, low in dosage and not prone to generating drug resistance.

The invention discloses a preparation method of a hypocrellin-transferrin targeted drug delivery system and an application of the hypocrellin-transferrin targeted drug delivery system in photodynamic therapy. The method comprises the following steps: with holo-transferrin as a carrier, inactivating the holo-transferrin by urea and beta-mercaptoethanol, and making a three-dimensional structure loose to expose Fe-ion coordination sites; adding excessive hypocrellin, coordinating with Fe coordination sites, eliminating uncombined HA and urea through dialysis, and restoring the three-dimensional structure of holo-transferrin with beta-mercaptoethanol, thereby obtaining the hypocrellin-transferrin targeted drug delivery system. The method is simple in preparation and good in application prospect; the hypocrellin-transferrin targeted drug delivery system can be prepared into freeze-dried powder for storage, and the freeze-dried powder is prepared into a preparation suitable for intravenous injection after being dissolved. Due to the tumor targeting action of holo-transferrin in the system, the photosensitive anti-tumor activity of hypocrellin can be significantly strengthened by the targeted drug delivery system.

The invention discloses polyamine phthalocyanine and a derivative thereof. The structural general formula of the derivative of polyamine phthalocyanine is shown in descriptions. The derivative of polyamine phthalocyanine, disclosed by the invention, has relatively good solubility and photosensitive activity, has a certain targeting function and is suitable for serving as a photosensitizer for PDT (Photodynamic Therapy). The invention further relates to preparation methods and application of polyamine phthalocyanine and the derivative thereof.

The invention provides a chromene pyridine derivative fluorescent probe as well as a preparation method and application thereof. The structural formula of the fluorescent probe is shown in the specification. The specific preparation method comprises the following steps: dissolving 3H-benzo[f]chromene-2-formaldehyde and 4-methyl-1-(2-morpholine-4-ethyl)-pyridine bromide in ethanol, dropwise addingpiperidine as a catalyst, carrying out reflux stirring at 80 DEG C for 4-5 hours, cooling, standing to room temperature, carrying out reduced pressure suction filtration, and cleaning the obtained solid with ethanol to obtain the chromene pyridine derivative fluorescent probe. The chromene pyridine derivative fluorescent probe can selectively react with hypochlorite under pure water phase physiological conditions, the solution is yellow and fades, meanwhile, red fluorescence is remarkably weakened, and the chromene pyridine derivative fluorescent probe is particularly applied to convenient detection of hypochlorite in cytolysosome as a fluorescent probe. The probe does not need any organic solvent for hydrotropy in a working environment, is very beneficial to being applied to a biologicalsystem, and has wide potential application value.

The invention discloses a multifunctional underwear fabric containing active polypeptide, underwear prepared from the multifunctional underwear fabric and a preparation method of the multifunctional underwear fabric. The method comprises the steps: 1, pretreating fabric with the surface containing hydroxyl and/or amino groups; 2, activating reaction groups on the fabric by adopting a chemical reagent; 3, detecting the density of the activated groups on the fabric; 4, reacting the activated fabric with active polypeptide; 5, cleaning the fabric; 6, naturally air-drying or drying the fabric at low temperature; 7, cutting the fabric according to a underwear sample plate; 8, conveying the fabric to a garment production line for sewing; and 9, carrying out high-temperature ironing on sewn underwear, packaging and warehousing. The invention further provides the multifunctional underwear fabric containing the active polypeptide and underwear prepared through the method. According to the invention, the active polypeptide is utilized to modify the existing fabric, so that the underwear produced by utilizing the fabric has the functions of protecting skin, beautifying skin, repairing skin surface inflammation and the like.