Anti-microbial lipopenic compound with target function and preparation method thereof

Abstract

The invention discloses an anti-microbial lipopenic compound with a target function and a preparation method thereof. The anti-microbial lipopenic compound is prepared from lipopeptid and neoglycolipid which are self assembled in solution, wherein the lipopeptid and the neoglycolipid are similar in structure, the lipopeptid is prepared from bioactive peptide and a hydrophobic chain section, and the neoglycolipid is prepared from oligosaccharide and a similar hydrophobic chain section. According to the anti-microbial lipopenic compound with the target function, a glycosyl unit in the neoglycolipid is utilized as a chemotactic agent to target bacterial membranes, and the anti-microbial lipopeptid plays an anti-microbial role; thus, the anti-microbial lipopenic compound has the characteristics of being high in anti-microbial activity, long in action time, low in dosage and not prone to generating drug resistance.

Description

technical field

[0001] The invention is an antibacterial lipopeptide complex with targeting function, relates to a material that can be used in biomedicine and other aspects, and belongs to the field of biomedical materials. Background technique

[0002] In recent years, with the widespread use and abuse of antibiotics, multi-drug-resistant bacteria have emerged, and infections caused by multi-drug-resistant bacteria have posed a serious threat to human health. More importantly, the development of antibiotics is far behind the speed of bacterial resistance. In order to solve this problem, the main measures taken by researchers include research and development of new antibiotics, search for new drug targets, and use of drug carrier systems.

[0003] Antimicrobial peptides are short peptides produced by the natural immune system in the host defense system and have a certain bactericidal effect, and have broad-spectrum antibacterial properties. Many antimicrobial peptides not...

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