A kind of multifunctional probe and its preparation method and application

A multifunctional probe and probe technology, which can be used in pharmaceutical formulations, preparations for in vivo experiments, and materials for wave energy or particle radiation treatment, etc. Easy to metabolize, excellent biocompatibility

Inactive Publication Date: 2019-02-22
SHANGHAI JIAO TONG UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, its preparation process is cumbersome and the yield is not high.

Method used

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  • A kind of multifunctional probe and its preparation method and application
  • A kind of multifunctional probe and its preparation method and application
  • A kind of multifunctional probe and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] a. Add 10 parts of cetyltrimethylammonium bromide to 150 parts of deionized water, stir at 50℃ for 1 hour, after the surfactant is completely dissolved, add 10 parts of chloroauric acid solution with a mole fraction of 10μM After a little stirring, 0.15 parts of silver nitrate solution with a mole fraction of 0.25 mM was added. After stirring uniformly, 0.1 part of sodium borohydride was added to generate a sol mixture, and then the mixture was incubated at 37° C. for 10 hours, and washed with deionized water at 9000 rpm to obtain a concentrated solution of gold nanorods with surfactant removed.

[0069] b. Add 200 parts of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide sodium hydrochloride to 10 parts of deionized water. After the crosslinking agent is dissolved, add 400 parts of sodium hyaluronate powder Add and stir for 3 hours to obtain a sodium hyaluronate solution that activates carboxyl groups.

[0070] c. Disperse 5 parts of gold nano rod concentrate obtained in a ab...

Embodiment 2

[0075] a. Add 20 parts of cetyltrimethylammonium bromide to 200 parts of deionized water, stir at 60°C for 1 hour, after the surfactant is completely dissolved, add 15 parts of chloroauric acid solution with a mole fraction of 10μM After a little stirring, 0.3 parts of silver nitrate solution with a mole fraction of 0.25 mM was added. After stirring uniformly, 0.1 part of sodium borohydride was added to generate a sol mixture, and then the mixture was kept at 37° C. for 12 hours, and washed with deionized water at 9000 rpm to obtain a concentrated solution of gold nanorods to remove surfactants.

[0076] b. Add 200 parts of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide potassium hydrochloride to 10 parts of deionized water. After the crosslinking agent is dissolved, add 300 parts of sodium hyaluronate powder Add and stir for 3 hours to obtain a sodium hyaluronate solution that activates carboxyl groups.

[0077] c. Disperse 10 parts of the gold nano rod concentrate obtained in the...

Embodiment 3

[0082] a. Add 30 parts of cetyltrimethylammonium bromide to 200 parts of deionized water, and stir for 1 hour at 80°C or above. After the surfactant is completely dissolved, add 15 parts of chloroauric acid with a mole fraction of 10μM After the solution was stirred for a while, 0.2 parts of silver nitrate solution with a mole fraction of 0.25 mM was added. After stirring evenly, 0.2 part of sodium borohydride was added to generate a sol mixture, and then kept at 40° C. for 14 hours, and washed with deionized water at 9500 rpm to obtain a concentrated solution of gold nano rods to remove surfactants.

[0083] b. Add 100 parts of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide potassium hydrochloride to 10 parts of deionized water. After the crosslinking agent is dissolved, add 500 parts of sodium hyaluronate powder Add and stir for 3 hours to obtain a sodium hyaluronate solution that activates carboxyl groups.

[0084] c. Disperse 10 parts of the gold nanorod concentrate obtained in...

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Abstract

The invention discloses a multifunctional probe and a preparation method and application thereof. The nano diagnosis and treatment probe with the two functions of magnetic resonance imaging and thermal therapy is formed in the mode that nano gold bars are formed by adding surfactant, chloroauric acid, a reduction agent and silver nitrate, target macromolecules are inoculated, and gadolinium ions are adsorbed. The preparation method is simple, the probe is good in dispersity in an aqueous solution, good in stability and capable of meeting requirements of clinical application and combining radiography and thermal therapy, and the dual functions of lymphoma diagnosis and treatment are achieved.

Description

Technical field [0001] The invention relates to the field of preparation of nanomaterials, in particular to a multifunctional probe and its preparation method and application, and in particular to a nano gold rod diagnostic and therapeutic probe with lymphatic targeting and both magnetic resonance imaging and hyperthermia functions. Preparation. Background technique [0002] In terms of tumor treatment and diagnosis, it is of great significance to be able to combine treatment and diagnosis to realize the integration of diagnosis and treatment. With the development of medical engineering and computer technology, molecular imaging provides a faster and more intuitive basis for tumor clinical diagnosis. Among them, magnetic resonance imaging has been widely used clinically due to its advantages of high soft tissue resolution, many imaging parameters, large image information and no ionization damage. Hyperthermia is a new therapy for the treatment of tumors. The curative effect ach...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/06
CPCA61K41/0052A61K49/12B22F9/24
Inventor 何丹农乔宇易帆姬豫朱君金彩虹
Owner SHANGHAI JIAO TONG UNIV
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