Polyamine phthalocyanine and derivative thereof as well as preparation and application of polyamine phthalocyanine and derivative thereof

A technology of phthalocyanine derivatives and derivatives, applied in medical preparations containing active ingredients, drug combinations, organic chemistry, etc., can solve the problems of lack of phthalocyanine derivatives, low aggregation degree, etc.

Inactive Publication Date: 2014-08-27
NANJING NORMAL UNIVERSITY
View PDF2 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far, phthalocyanine derivatives that can satisfy both good antitumor ac

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Polyamine phthalocyanine and derivative thereof as well as preparation and application of polyamine phthalocyanine and derivative thereof
  • Polyamine phthalocyanine and derivative thereof as well as preparation and application of polyamine phthalocyanine and derivative thereof
  • Polyamine phthalocyanine and derivative thereof as well as preparation and application of polyamine phthalocyanine and derivative thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0075] Polyamine phthalocyanine R1 and preparation method thereof, represented by reaction formula as figure 2 shown.

[0076] (1) Under the protection of nitrogen, the dichloromethane solution of triphenylchloromethane is slowly added dropwise into the dichloromethane solution of ethylenediamine with a constant pressure titration funnel, the molar ratio of triphenylchloromethane and ethylenediamine 1:3, titrated for about 4 hours, then stirred at room temperature for 4 hours to obtain intermediate 10;

[0077] (2) Add intermediate 10 and p-hydroxybenzaldehyde to the ethanol solution at a molar ratio of 1:1.1, add 1.5 equivalents of sodium borohydride after reacting for 3 hours, and continue stirring for 3 hours to obtain intermediate 12;

[0078] (3) Under nitrogen protection, intermediate 12, basic catalyst and 4-nitrophthalonitrile were added to DMF at a molar ratio of 1:2:1.2, and reacted at 40°C for 4 hours to obtain intermediate 13;

[0079] (4) Under the protection of...

Embodiment 2

[0081] Polyamine phthalocyanine R2 and preparation method thereof, represented by reaction formula as figure 2 shown.

[0082] (1) Under the protection of nitrogen, the dichloromethane solution of triphenylchloromethane is slowly added dropwise into the dichloromethane solution of ethylenediamine with a constant pressure titration funnel, the molar ratio of triphenylchloromethane and ethylenediamine 1:3, titrated for about 4 hours, then stirred at room temperature for 4 hours to obtain intermediate 10;

[0083] (2) Add intermediate 10 and p-hydroxybenzaldehyde to the ethanol solution at a molar ratio of 1:1.1, add 1.5 equivalents of sodium borohydride after reacting for 3 hours, and continue stirring for 3 hours to obtain intermediate 12;

[0084] (3) Under nitrogen protection, intermediate 12, basic catalyst and 4-nitrophthalonitrile were added to DMF at a molar ratio of 1:2:1.2, and reacted at 40°C for 4 hours to obtain intermediate 13;

[0085] (4) Under the protection of...

Embodiment 3

[0088] Polyamine phthalocyanine R3 and its preparation, represented by the reaction formula as image 3 shown.

[0089](1) Diethylethylenediamine 10' and p-hydroxybenzaldehyde were added to the ethanol solution at a molar ratio of 1:1.1, and 1.5 equivalents of sodium borohydride was added after the reaction for 3 hours, and the stirring reaction was continued for 3 hours to obtain the intermediate 12';

[0090] (2) Under nitrogen protection, intermediate 12', basic catalyst and 4-nitrophthalonitrile were added to DMF at a molar ratio of 1:2:1.2, and reacted at 40°C for 4 hours to obtain intermediate 13' ;

[0091] (3) Under the protection of nitrogen, intermediate 13', metal salt, and DBU are added in n-amyl alcohol in a molar ratio of 1:1:1, and the polyamine phthalocyanine R3 is refluxed for 24 hours;

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses polyamine phthalocyanine and a derivative thereof. The structural general formula of the derivative of polyamine phthalocyanine is shown in descriptions. The derivative of polyamine phthalocyanine, disclosed by the invention, has relatively good solubility and photosensitive activity, has a certain targeting function and is suitable for serving as a photosensitizer for PDT (Photodynamic Therapy). The invention further relates to preparation methods and application of polyamine phthalocyanine and the derivative thereof.

Description

technical field [0001] The invention relates to a phthalocyanine and its preparation and application, in particular to a polyamine phthalocyanine and its derivatives, as well as their preparation and application. Background technique [0002] Photodynamic therapy (PDT) is a new type of therapy developed in recent years based on photodynamic response to treat precancerous lesions and malignant tumors and other diseases. The earliest research on PDT in this century can be traced back to 1960, when R.L. Lipson and S. Schwartz injected crude hematoporphyrin into the patient's body to make the tumor lesion tissue fluorescent visualized during the operation. Different from traditional chemotherapy, radiotherapy and surgery, PDT realizes the damage and death of tumor lesion tissue and cells through the comprehensive action of three non-toxic elements: light, photosensitizer and oxygen. Compared with the current traditional therapy, PDT not only has unique advantages such as high s...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): C07D487/22A61K41/00A61P35/00
CPCA61K41/0071C07D487/22
Inventor 魏少华王傲周林卢珊周家宏林云
Owner NANJING NORMAL UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap