Patents
Literature
41results about How to "High phototoxicity" patented technology
Efficacy Topic
Property
Owner
Technical Advancement
Application Domain
Technology Topic
Technology Field Word
Patent Country/Region
Patent Type
Patent Status
Application Year
Inventor
Fullereneporphyrin derivate photosensitizer as well as preparation method and application thereof
ActiveCN103724356AIncrease profitTo overcome the shortcoming of needing sufficient oxygen concentrationAntibacterial agentsOrganic active ingredientsCancer cellPhotosensitizer
The invention discloses a fullereneporphyrin derivate photosensitizer as well as a preparation method and application thereof. The structural formula of the fullereneporphyrin derivate photosensitizer is shown as the formula I. The fullereneporphyrin derivate photosensitizer can overcome the defect that a traditional photosensitizer needs enough oxygen concentration, and effective reactive oxygen can still be generated under the low oxygen concentration, so that a good treatment effect can be achieved. The fullereneporphyrin derivate photosensitizer has the advantages of high phototoxicity, low dark toxicity, high selectivity in pickup of cancer cells and the like, and has a broad spectrum, a killing effect on cancer cells and a remarkable bacteria killing effect. Most of all, the fullereneporphyrin derivate can be metabolized in a mouse body, and is a novel photosensitizer with a good prospect.
Owner:赤峰福纳康生物技术有限公司 +1
Tyrosine phthalocyanines derivates, preparation thereof and applications in preparation of photodynamic drugs
InactiveCN101289450AHigh photosensitivityGood compatibilityOrganic active ingredientsGroup 3/13 element organic compoundsPhotosensitizerN dimethylformamide
The invention relates to a tyrosine phthalocyanine derivative which has a structural general formula as the right, in the formula, M is equal to Zn or Al, R is equal to H, Na or CH2CH3. The preparation method for the tyrosine phthalocyanine derivative is: (1) an intermediate II is obtained through the reaction of tyrosine and 4-nitrophthalic nitrile with protected amino group; (2) an intermediate III can be obtained by detracting Boc in the solution of dichloromethane and trifluoroacetic acid; (3) the tyrosine phthalocyanine derivative I can be obtained by cyclizing of the dinitriles intermediate that comprises the tyrosine; wherein, the Boc is di-tert-butyl dicarbonate, a DMF is N, N-dimethylformamide, and a DBU is 1,8-diazacyclo(5,4,0)hendecene-7. The invention also comprises the application of the tyrosine phthalocyanine photosensitizers in preparing photodynamic medicines.
Owner:NANJING NORMAL UNIVERSITY
High-speed large-view-field digital scanning light sheet microimaging system
InactiveCN111273433AHigh resolutionIncrease contrastMicroscopesFluorescence/phosphorescenceBeam splitterBeam scanning
The invention discloses a high-speed large-view-field digital scanning light sheet microscopic imaging system. The system comprises a light source module, a transverse view field expansion module, a scanning module, an illumination module and a detection module which are sequentially arranged according to a light path, light generated by the light source module passes through the transverse view field expansion module to obtain an effective view field for expanding a final illumination area. The scanning module scans a line beam received from the transverse view field expansion module into a surface beam, the illumination module performs fluorescence excitation by adopting a beam splitter, a first illumination objective lens and a second illumination objective lens, and the detection module realizes fluorescence detection imaging by adopting a line detector. The axial resolution is improved, the influence of phototoxicity and photobleaching on a sample is reduced, the imaging has higher resolution and contrast ratio by using the linear array detector, the imaging speed is higher, and the cost of the detector is saved.
Owner:SUZHOU INST OF BIOMEDICAL ENG & TECH CHINESE ACADEMY OF SCI
Preparation method and application in preparation of photodynamic therapy medicines of fat-soluble photosensitizer loaded on inorganic salt carrier
InactiveCN101850118AEasy to prepareEasy to operateOrganic active ingredientsSenses disorderDispersitySolubility
The invention relates to a preparation method and application in the preparation of photodynamic therapy medicines of a fat-soluble photosensitizer loaded on inorganic salt carrier or modified surface inorganic salt carrier. The preparation method comprises the following steps: in or without the presence of surfactant, firstly adding distilled water, DMSO solution of fat-soluble photosensitizer, chloride solution and phosphate solution, performing magnetic stirring, and obtaining calcium phosphate nanoparticles with the grain size less than 100nm of fat-soluble photosensitizer after the reaction, wherein the molar ratio of chloride solution to phosphate solution is 1:10-10:1. The preparation method of the invention is simple, is easy to operate and has high stability and low cost; the diameter of the prepared nanoparticles is about 70nm, thus facilitating the preparation and storage of the product; the nanoparticles have high water-solubility and good dispersity, and can be used to promote the effective transmission of the fat-soluble photosensitizer in blood and eliminate the toxic or side effects of the fat-soluble photosensitizer which is used alone; and the nanoparticles have low toxicity in the dark and high phototoxicity.
Owner:NANJING NORMAL UNIVERSITY
Preparation method for fat-soluble phtosensitizer nanoparticles and application thereof
InactiveCN102988289AEasy to prepareEasy to operateSenses disorderEnergy modified materialsSolubilityPhotodynamic therapy
The invention discloses a preparation method for fat-soluble phtosensitizer nanoparticles. Under the condition that that the potential of hydrogen (pH) value is 1-14, a fat-soluble phtosensitizer or soluble inorganic salt is added into a reaction medium respectively to prepare A and B systems and the A system and the B system are mixed. Or, the fat-soluble phtosensitizer or soluble inorganic salt are simultaneously added into the reaction medium and then mixed. The fat-soluble phtosensitizer self-assembles to form a nanometer structure and the fat-soluble phtosensitizer nanoparticles are obtained after separation and purification. The fat-soluble phtosensitizer nanoparticles prepared by the method provided by the invention has high water-solubility and good dispersibility and can be steadily dispersed in water phase, so that the effective transmission of the fat-soluble phtosensitizer nanoparticles in blood is promoted. Meantime, the method has the advantages of simpleness, easiness in operation, high stability and low cost. The invention also relates to the application of the fat-soluble phtosensitizer nanoparticles prepared by the method in preparing photodynamic therapy medicine.
Owner:NANJING NORMAL UNIVERSITY
Method of producing water-solubility hypocrellin titanium dioxide nano granule
InactiveCN101129337AGuaranteed normal transmissionReduce phototoxic side effectsOrganic active ingredientsPowder deliverySolubilityWater soluble
The invention discloses a preparing method of soluble bamboo bacterioruberin titanium oxide nanometer particle, which comprises the following steps: hydrolyzing organic titanium compound in the alcohol, acetic acid and distilled water; dripping the alcohol solution of bamboo bacterioruberin slowly; stirring; reacting to add the distilled water; adjusting the pH value of the solution to 7. 0; dialyzing to remove alcohol and small molecular compound; freezing; drying; obtaining the product; setting the weight rate of organic titanium compound and acetic acid at 1: 2-6; setting the weight rate of organic titanium compound and alcohol and distilled water at 1: 10-20: 1-3. The bamboo bacterioruberin is the bamboo bacterioruberin methyl, bamboo bacterioruberin ethyl or derivant of two compounds and the organic titanium compound is titanic acid tetraacetate, titanic acid tetra-n-propyl ester, tetraisopropoxy titanium, titanic acid tetera-n-butoyl or polytitanium acid butoyl. The invention has simple, easy and stable operation with diameter of soluble nanometer particle less than 150nm, which is beneficial to prepare and reserve the product.
Owner:NANJING NORMAL UNIVERSITY
Method for preparing medicament-nanometer calcium phosphate composite system taking fat soluble photosensitizer as framework and application of system in preparation of medicaments for photodynamic therapy
InactiveCN102198271AEasy to prepareEasy to operateEnergy modified materialsPharmaceutical non-active ingredientsSolubilityPhosphate
The invention discloses a method for preparing a medicament-nanometer calcium phosphate composite system taking a fat soluble photosensitizer as a framework, which comprises the following steps of: under the condition that phosphoryl-containing organic matters exist or do not exist, adding distilled water and aqueous solution of calcium salt, and stirring uniformly to prepare a system A; adding the distilled water and aqueous solution of phosphate, and stirring uniformly to prepare a system B; and adding fat soluble photosensitizer solution into the system A or the system B or adding the fat soluble photosensitizer solution into the systems A and B simultaneously, stirring uniformly, and mixing the system A and the system B to obtain the medicament-nanometer calcium phosphate composite system taking the fat soluble photosensitizer as the framework. The administration system prepared by the method is high in water solubility and dispersibility and can promote the effective transmission of the fat soluble photosensitizer in blood, and the medicine loading rate of the administration system is increased. Simultaneously, the preparation method is simple, easy to operate, high in stability and low in cost. The invention also relates to application of the administration system prepared by the method in the preparation of medicaments for photodynamic therapy.
Owner:NANJING NORMAL UNIVERSITY
Method for preparing water soluble hypocrellin silica nanometer particle and its application in preparing venous injection
InactiveCN101084874AEasy to manufactureEasy to storeOrganic active ingredientsPharmaceutical delivery mechanismActive agentFreeze-drying
Preparation method of water-soluble hypocrelline silica nanoparticle comprises carrying out hydrolysis of single silicane or multiple silicanes to obtain nano-silica with core-shell structure, enveloping hypocrelline under the existence or inexistence of surfactant, dialysing to remove solvent and small moleculal chemical compound, and freeze drying to obtain water-soluble hypocrelline silica nanoparticle with particle diameter less than 150nm suitable for intravenous injection. The invention also provides thr application of the water soluble hypocrelline silica nanoparticle in preparing photodynamic medicinal intravenous injection. The inventive preparation method has simple and easy operation and high product stability. The nanoparticle has good water-solubility and dispersity, low dark toxicity, and high phototoxicity; can not liberate hypocrelline thereby eliminating its photo toxico-adverse side effect. Hypocrellines can gather in intrastitial mitochondrion, effectively improve phototherapy efficiency, and reduce pharmic consumption.
Owner:CHANGSHU NANJING NORMAL UNIV DEV RES INST
High-resolution light sheet microscopic imaging system for observing free-moving zebra fish
ActiveCN111258045AReduce the impactImproved Axial ResolutionMicroscopesFluorescence/phosphorescenceBeam splitterFluorescence
The invention discloses a high-resolution light sheet microscopic imaging system for observing free-moving zebra fish. The system comprises a light source module, a transverse view field expansion module, a scanning module, an illumination module and a detection module which are sequentially arranged according to a light path, light generated by the light source module passes through the transverse view field expansion module to obtain an effective view field for expanding a final illumination area; the scanning module scans a linear light beam received from the transverse view field expansionmodule into a surface light beam; the illumination module and the detection module adopt a beam splitter, an illumination unit, a first illumination objective lens and a second illumination objectivelens to enable transmitted infrared light to carry structural information of a zebra fish sample to enter the detection module, and the detection module adopts an infrared camera and a complementarymetal oxide semiconductor camera to realize near-infrared light and fluorescence detection imaging respectively. The method has the advantages of no influence on the sample, high transverse and axialresolution and high imaging speed.
Owner:SUZHOU INST OF BIOMEDICAL ENG & TECH CHINESE ACADEMY OF SCI
Polyamine phthalocyanine and derivative thereof as well as preparation and application of polyamine phthalocyanine and derivative thereof
InactiveCN104003993AImprove solubilityHigh activityOrganic chemistryEnergy modified materialsSolubilityPhotodynamic therapy
The invention discloses polyamine phthalocyanine and a derivative thereof. The structural general formula of the derivative of polyamine phthalocyanine is shown in descriptions. The derivative of polyamine phthalocyanine, disclosed by the invention, has relatively good solubility and photosensitive activity, has a certain targeting function and is suitable for serving as a photosensitizer for PDT (Photodynamic Therapy). The invention further relates to preparation methods and application of polyamine phthalocyanine and the derivative thereof.
Owner:NANJING NORMAL UNIVERSITY
D-benzothiadiazole-TB(-D) derivative as well as synthesis method and application thereof
ActiveCN113735864AThe synthesis method is simpleEasy post-processingOrganic chemistryPhotodynamic therapyFluoProbesStaining
The invention discloses a D-benzothiadiazole-TB(-D) derivative as well as a synthesis method and application thereof. The structural formula of the D-benzothiadiazole-TB(-D) derivative is shown as a formula I or II. The D-benzothiadiazole-TB(-D) derivative has large Stokes displacement, shows excellent luminescence property, has excellent solid luminescence and has the potential of becoming an excellent OLED (Organic Light Emitting Diode) material. The D-benzothiadiazole-TB(-D) derivative has a wide pH application range and can be applied to a human physiological environment; the D-benzothiadiazole-TB(-D) derivative has effective and good response to viscosity, and has the possibility of becoming a viscosity response fluorescent probe; the D-benzothiadiazole-TB(-D) derivative has recognition capability on Fe<3+> and is expected to become an excellent Fe<3+> fluorescent probe; and the D-benzothiadiazole-TB(-D) derivative has a good PDT effect, can perform dyeing imaging on A549 cells, and expands the variety of photosensitizers.
Owner:XUZHOU NORMAL UNIVERSITY
Aminocarbamoyl compounds for the treatment of viral infections
PendingUS20220064128A1Superior Clpro inhibition activityLow Cytochrome P45 （CYP） inhibitionAntiviralsPeptidesAcyl groupMicrobiology
Owner:F HOFFMANN LA ROCHE & CO AG
Polypyridine ruthenium cooperation compound having light activity, and applications thereof
ActiveCN110857310AHigh phototoxicityIncrease intakeRuthenium organic compoundsOrganic active ingredientsSinglet oxygenConjugated system
According to the invention, Ru (II) cooperation compounds with different conjugated systems are synthesized by modifying ligands of a polypyridine ruthenium cooperation compound based on [Ru(bpy)3]<2+> as a core, and the influence of ligand conjugated structures on the singlet oxygen yield of the cooperation compounds is studied; and in photodynamic therapy on tumors, the cooperation compound hasthe maximum singlet oxygen yield and has high phototoxicity under illumination, the uptake amount of cells to the cooperation compound is increased, the increase of the uptake amount leads to the possible chemical anti-cancer effect after the cooperation compound enters the cells, so that the anti-tumor activity of the cooperation compound is further improved.
Owner:NANJING UNIV
Applications of high-charge cationic porphyrin in preparation of PDT nanometer photosensitizer
ActiveCN110642865AGood biocompatibilityEasy to metabolize and decomposeOrganic chemistryEnergy modified materialsPhotosensitizerNanocarriers
The invention discloses applications of high-charge cationic porphyrin in preparation of a PDT nanometer photosensitizer. According to the invention, an eight-charge water-soluble porphyrin compound octaiodated 5,10,15,20-tetra{4-[2-[1, 4-dimethyl-4-(2-hydroxyethyl)piperazine-1-yl]ethoxy]phenyl}porphyrin (OMEPzEOPP)<8+>8I<-> (short for OMEPzEOPP) and a polypeptide nanometer carrier are combined, and the obtained material is used in preparation of a nanometer PDT photosensitizer capable of specifically recognizing tumor cells.
Owner:TIANJIN UNIV
Preparation method of high-gloss high-stability Elsinochrome silicon oxide nano granule and application thereof in preparing intravenous injection agent
ActiveCN101502654AImprove photostabilityGood water solubilityOrganic active ingredientsPowder deliverySurface-active agentsWater soluble
The invention relates to a method for preparing elsinochrome silicon dioxide nanoparticle with high photostability and fine water-solubility and an application thereof in preparing vein injection, comprising the following preparation steps: (1). hydrolyzing a single silane terpenoid or multiple silane terpenoids under alkaline conditions to generate nanometer silicon dioxide with a nuclear shell structure; (2). encapsulating elsinochrome in absence or in presence of surface active agents to prepare the elsinochrome silicon dioxide nanoparticle which suits vein injection, features relatively high photostability and fine water-solubility and has a particle diameter less than 200 nm; mole ratio relation between the reagents elsinochrome and silane ranges from 1:1 to 1: 10000. The photostability of the silicon dioxide nanoparticle is improved, photodegradation loss, preservation difficulty and preservation cost caused in the process of R&D, production and transportation and in use links are effectively reduced; moreover, the preparation method is simple, the operation is easy; furthermore, the capacity of active oxygen such as O2 is strengthened, the invisible toxicity is low and the optical toxicity is high.
Owner:常熟紫金知识产权服务有限公司
Disease detection and treatment through activation of compounds using external energy
InactiveUS20160008468A1Enhance abilityHigh yieldSonopheresisBiocideExternal energyAbnormal tissue growth
Described herein are compounds for the detection, diagnosis, and treatment of specific diseased tissues, including hyper-proliferative tissues such as tumors, and other tissue diseased with microbial and / or infectious species, using energy-activation methods. In particular, compounds sensitive to externally applied energy, including light and / or ultrasound; that also specifically accumulate in diseased target tissue, are provided.
Owner:FRONTIER SCI INC
Preparation method for graphene oxide-TiO2-hypocrellin A three-component compound system and application thereof in photodynamic therapy
InactiveCN105412925AImproved visible light responsivenessGood dispersionPhotodynamic therapyPharmaceutical non-active ingredientsDispersityOxygen
The invention relates to a preparation method for graphene oxide-TiO2-hypocrellin A three-component compound system and application thereof in photodynamic therapy. The preparation method for the three-component compound system comprises the steps of firstly, oxidizing graphite through strong oxidant and then washing the oxidized graphite through hydrochloric acid to obtain an aqueous solution of graphene oxide with an electronegative surface; secondly, obtaining an aqueous solution of surface positively charged TiO2 through a sol-gel method; thirdly, achieving effective compounding of the hypocrellin A and the graphene oxide through pi-pi interaction and intermolecular hydrogen bonds between the hypocrellin A and the graphene oxide, and achieving effective compounding of TiO2, the hypocrellin A and the graphene oxide in the aqueous phase through the electrostatic interaction between TiO2 and graphene oxide-hypocrellin A. According to the preparation method, the medicine carrying system is established at the room temperature, so that influence of the high temperature on activity of medicine is prevented; the obtained nanometer compound system is good in dispersity of aqueous phase, has a multiple sensitization mechanism, can improve the active oxygen generation capacity of hypocrellin A remarkably and is low in dark toxity and remarkably improved in phototoxicity compared with hypocrellin A.
Owner:NANJING NORMAL UNIVERSITY
Metal iridium (III) complex as well as preparation method and application thereof
PendingCN113788861ALow in vitro cytotoxicityHigh phototoxicityIndium organic compoundsPhotodynamic therapyLung cancer cellPulmonary Cancers
The invention provides an iridium (III) complex and a preparation method and application thereof. The anti-tumor iridium (III) complex with a structure as shown in a formula (1) or a formula (2) in the invention can specifically target mitochondria or lysosome, has low dark toxicity and high phototoxicity, and has a very high phototoxicity index in tumor cells, particularly in non-small cell lung cancer cells Meanwhile, the anti-tumor metal iridium (III) complex can be used as a photosensitizer to participate in photodynamic therapy. Compared with a traditional photosensitizer, the anti-tumor metal iridium (III) complex has the advantages of being good in water solubility, high in light stability, low in dark toxicity and the like, and can realize integration of diagnosis and treatment.
Owner:山东普力强生物科技有限公司
Method for preparing medicament-nanometer calcium phosphate composite system taking fat soluble photosensitizer as framework and application of system in preparation of medicaments for photodynamic therapy
InactiveCN102198271BEasy to prepareEasy to operateEnergy modified materialsPharmaceutical non-active ingredientsSolubilityPhosphate
Owner:NANJING NORMAL UNIVERSITY
Preparation method and application in preparation of photodynamic therapy medicines of fat-soluble photosensitizer loaded on inorganic salt carrier
InactiveCN101850118BEasy to prepareEasy to operateOrganic active ingredientsSenses disorderSolubilityDispersity
The invention relates to a preparation method and application in the preparation of photodynamic therapy medicines of a fat-soluble photosensitizer loaded on inorganic salt carrier or modified surface inorganic salt carrier. The preparation method comprises the following steps: in or without the presence of surfactant, firstly adding distilled water, DMSO solution of fat-soluble photosensitizer, chloride solution and phosphate solution, performing magnetic stirring, and obtaining calcium phosphate nanoparticles with the grain size less than 100nm of fat-soluble photosensitizer after the reaction, wherein the molar ratio of chloride solution to phosphate solution is 1:10-10:1. The preparation method of the invention is simple, is easy to operate and has high stability and low cost; the diameter of the prepared nanoparticles is about 70nm, thus facilitating the preparation and storage of the product; the nanoparticles have high water-solubility and good dispersity, and can be used to promote the effective transmission of the fat-soluble photosensitizer in blood and eliminate the toxic or side effects of the fat-soluble photosensitizer which is used alone; and the nanoparticles have low toxicity in the dark and high phototoxicity.
Owner:NANJING NORMAL UNIVERSITY
A kind of polyamine phthalocyanine and its derivatives, their preparation and application
InactiveCN104003993BImprove solubilityHigh activityOrganic chemistryEnergy modified materialsSolubilityPhotodynamic therapy
The invention discloses polyamine phthalocyanine and a derivative thereof. The structural general formula of the derivative of polyamine phthalocyanine is shown in descriptions. The derivative of polyamine phthalocyanine, disclosed by the invention, has relatively good solubility and photosensitive activity, has a certain targeting function and is suitable for serving as a photosensitizer for PDT (Photodynamic Therapy). The invention further relates to preparation methods and application of polyamine phthalocyanine and the derivative thereof.
Owner:NANJING NORMAL UNIVERSITY
Novel glycoconjugated chlorin derivatives and method of producing the same
InactiveUS20090318370A1Strong cytotoxicityImprove productivityBiocideSugar derivativesHydrogen atomMetallole
Disclosed is a novel glycoconjugated chlorin derivative which is useful as a substance for photodynamic therapy, is stable, and can act a photosensitizer having high phototoxicity even when used in a small quantity. Also disclosed is a method of producing the derivative. Specifically disclosed are a S-glycosylated chlorin derivative represented by the following general formula (1) and a metal complex thereof. In the general formula (1), X1 to X20 independently represent a group selected from the group consisting of F—, sugar-S—, sugar-Z-S— and sugar-O-Z-S— and at least one among X1 to X20 represents a group selected from the group consisting of sugar-S—, sugar-Z-S— and sugar-O-Z-S— (wherein F represents a fluorine atom, Z represents an oxygen atom, Z represents a hydrocarbon group having 1 to 6 carbon atoms); and R5 and R6 independently represent a hydrogen atom or an organic group or may together form a ring.
Owner:REI MEDICAL
A kind of preparation method and application of polyporphyrin compound
ActiveCN110790922BHigh yieldHigh phototoxicityEnergy modified materialsAntineoplastic agentsThioketalEthyl group
The invention belongs to the technical field of high polymer materials, biomedical materials and photodynamic therapy, and relates to a preparation method and application of a polymeric porphyrin compound. The preparation method comprises the following steps: dissolving tetracarboxylic acid modified tetraphenylporphyrin in an organic solvent, wherein the concentration is 0.1-1M; adding a thioketalcomonomer with terminal diamino into a reaction system, and finally adding 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride and 4-dimethylaminopyridine; heating the reaction system to 50-100 DEG C, and reacting for 24-72 hours; and after the reaction is finished, cooling to room temperature, settling and centrifuging, dialyzing an obtained crude product by using deionized water, and freeze-drying to obtain the polymeric porphyrin compound pPS.
Owner:DALIAN UNIV OF TECH
Fluorescent silica nanoparticles with nano-hydrophobic cage structure, preparation method and application thereof
ActiveCN111484842BThe preparation process is matureStable photophysical propertiesMethine/polymethine dyesPhotodynamic therapyPhotodynamic therapyCancer cell
The invention belongs to the technical field of biomedicine, and relates to a fluorescent silica nano-particle with a nano-hydrophobic cage structure, a preparation method and an application thereof. The organic fluorescent dye is covalently coated in the nano-hydrophobic cage structure encapsulated by the hydrophobic alkyl chain through the hydrolytic polymerization process of the silane coupling agent containing the hydrophobic alkyl chain. The fluorescent silica nanoparticles with a nano-hydrophobic cage structure prepared by the present invention have greatly improved its photophysical properties and long-term and stable imaging capabilities of cancer cells, and at the same time can achieve effective photodynamic therapy for cancer cells. The fields of imaging and cancer therapy have promising applications.
Owner:DALIAN UNIV OF TECH
Preparation method of up-conversion nanocrystal-hypocretin complex and application of the prepared complex in photosensitization therapy
InactiveCN104826111BAvoid Active EffectsAvoid the effects of the crystallization processEnergy modified materialsAntineoplastic agentsIn vivoSolvent
Owner:NANJING NORMAL UNIVERSITY
Application of a kind of highly charged cationic porphyrin in the preparation of pdt nano photosensitizer
ActiveCN110642865BGood biocompatibilityEasy to metabolize and decomposeOrganic chemistryEnergy modified materialsPhotosensitizerNanocarriers
Owner:TIANJIN UNIV
A kind of red carbon dot material, preparation method and application thereof
ActiveCN111747398BSave raw materialsLow costPhotodynamic therapyInorganic non-active ingredientsPhoto stabilitySinglet oxygen
The invention discloses a red carbon dot material, a preparation method and application thereof, and belongs to the technical field of preparation of luminous carbon nanometer materials. In the present invention, a specific carbon source and phosphate are dispersed in water for hydrothermal reaction to construct a singlet oxygen yield, high photostability, good water solubility, high phototoxicity, low dark toxicity, and in the phototherapy window. There are red fluorescent carbon dots with strong absorption within 600-1000nm, which can be widely used as photosensitizer in the preparation of photodynamic therapy cancer drugs, construction of drug delivery systems, fluorescence imaging, light-emitting devices and biosensing, etc., and has a very good market prospect.
Owner:JIANGNAN UNIV
Application of water-soluble cationic porphyrin in preparation of PDT nano photosensitizer
ActiveCN111558042ALow dark toxicityHigh synthesis efficiencyEnergy modified materialsMicrobiological testing/measurementPhotosensitizerPorphyrin
The invention discloses an application of water-soluble cationic porphyrin in preparation of a PDT nano photosensitizer. According to the method, a water-soluble cationic porphyrin compound, namely tetraiodized 5,10,15,20-tetra[1-methyl-1-piperidylethoxyphenyl]porphyrin (TMPipEOPP) 4<+>.4I<-> (hereinafter referred to as TMPipEOPP), is combined with a novel DNA nano structure; wherein the product is applied to preparation of the nano PDT photosensitizer with good biocompatibility.
Owner:TIANJIN UNIV
Polypyridine ruthenium complex and preparing method and application thereof
ActiveCN109970812AHigh phototoxicityLow dark toxicityHeavy metal active ingredientsOrganic active ingredientsRutheniumPhototoxicity
The invention discloses a polypyridine ruthenium complex. The complex has the structure shown in the formula I (the formula I can be seen in the description), wherein X- represents monovalent anions for balancing charges. The complex has high phototoxicity and low dark toxicity, can be well used for preparing photoactivation anti-tumor medicines, and can overcome the defect of the great toxic andside effects of traditional chemotherapy medicines. The invention further discloses a preparing method and application of the polypyridine ruthenium complex.
Owner:TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
A kind of polypyridine ruthenium complex and its preparation method and application
ActiveCN109970812BHigh phototoxicityLow dark toxicityOrganic active ingredientsEnergy modified materialsPharmaceutical drugLight activated
The invention discloses a polypyridine ruthenium complex, which has the structure described in the following formula I: wherein, X ‑ Represents a charge-balancing monovalent anion. The complex has high phototoxicity and low dark toxicity, can be preferably used in the preparation of photoactivated antitumor drugs, and can overcome the defect of large toxic and side effects of traditional chemotherapy drugs. The invention also discloses the preparation method and application of the polypyridine ruthenium complex.
Owner:TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI