41results about How to "High phototoxicity" patented technology

The invention relates to a tyrosine phthalocyanine derivative which has a structural general formula as the right, in the formula, M is equal to Zn or Al, R is equal to H, Na or CH2CH3. The preparation method for the tyrosine phthalocyanine derivative is: (1) an intermediate II is obtained through the reaction of tyrosine and 4-nitrophthalic nitrile with protected amino group; (2) an intermediate III can be obtained by detracting Boc in the solution of dichloromethane and trifluoroacetic acid; (3) the tyrosine phthalocyanine derivative I can be obtained by cyclizing of the dinitriles intermediate that comprises the tyrosine; wherein, the Boc is di-tert-butyl dicarbonate, a DMF is N, N-dimethylformamide, and a DBU is 1,8-diazacyclo(5,4,0)hendecene-7. The invention also comprises the application of the tyrosine phthalocyanine photosensitizers in preparing photodynamic medicines.

The invention discloses a preparing method of soluble bamboo bacterioruberin titanium oxide nanometer particle, which comprises the following steps: hydrolyzing organic titanium compound in the alcohol, acetic acid and distilled water; dripping the alcohol solution of bamboo bacterioruberin slowly; stirring; reacting to add the distilled water; adjusting the pH value of the solution to 7. 0; dialyzing to remove alcohol and small molecular compound; freezing; drying; obtaining the product; setting the weight rate of organic titanium compound and acetic acid at 1: 2-6; setting the weight rate of organic titanium compound and alcohol and distilled water at 1: 10-20: 1-3. The bamboo bacterioruberin is the bamboo bacterioruberin methyl, bamboo bacterioruberin ethyl or derivant of two compounds and the organic titanium compound is titanic acid tetraacetate, titanic acid tetra-n-propyl ester, tetraisopropoxy titanium, titanic acid tetera-n-butoyl or polytitanium acid butoyl. The invention has simple, easy and stable operation with diameter of soluble nanometer particle less than 150nm, which is beneficial to prepare and reserve the product.

The invention discloses a method for preparing a medicament-nanometer calcium phosphate composite system taking a fat soluble photosensitizer as a framework, which comprises the following steps of: under the condition that phosphoryl-containing organic matters exist or do not exist, adding distilled water and aqueous solution of calcium salt, and stirring uniformly to prepare a system A; adding the distilled water and aqueous solution of phosphate, and stirring uniformly to prepare a system B; and adding fat soluble photosensitizer solution into the system A or the system B or adding the fat soluble photosensitizer solution into the systems A and B simultaneously, stirring uniformly, and mixing the system A and the system B to obtain the medicament-nanometer calcium phosphate composite system taking the fat soluble photosensitizer as the framework. The administration system prepared by the method is high in water solubility and dispersibility and can promote the effective transmission of the fat soluble photosensitizer in blood, and the medicine loading rate of the administration system is increased. Simultaneously, the preparation method is simple, easy to operate, high in stability and low in cost. The invention also relates to application of the administration system prepared by the method in the preparation of medicaments for photodynamic therapy.

The invention discloses a high-resolution light sheet microscopic imaging system for observing free-moving zebra fish. The system comprises a light source module, a transverse view field expansion module, a scanning module, an illumination module and a detection module which are sequentially arranged according to a light path, light generated by the light source module passes through the transverse view field expansion module to obtain an effective view field for expanding a final illumination area; the scanning module scans a linear light beam received from the transverse view field expansionmodule into a surface light beam; the illumination module and the detection module adopt a beam splitter, an illumination unit, a first illumination objective lens and a second illumination objectivelens to enable transmitted infrared light to carry structural information of a zebra fish sample to enter the detection module, and the detection module adopts an infrared camera and a complementarymetal oxide semiconductor camera to realize near-infrared light and fluorescence detection imaging respectively. The method has the advantages of no influence on the sample, high transverse and axialresolution and high imaging speed.

The invention discloses polyamine phthalocyanine and a derivative thereof. The structural general formula of the derivative of polyamine phthalocyanine is shown in descriptions. The derivative of polyamine phthalocyanine, disclosed by the invention, has relatively good solubility and photosensitive activity, has a certain targeting function and is suitable for serving as a photosensitizer for PDT (Photodynamic Therapy). The invention further relates to preparation methods and application of polyamine phthalocyanine and the derivative thereof.

The present invention relates to compounds of formula (I),

wherein R¹-R⁵ and L are as described herein, and their pharmaceutically acceptable salt thereof, and compositions including the compounds and methods of using the compounds.

The invention discloses applications of high-charge cationic porphyrin in preparation of a PDT nanometer photosensitizer. According to the invention, an eight-charge water-soluble porphyrin compound octaiodated 5,10,15,20-tetra{4-[2-[1, 4-dimethyl-4-(2-hydroxyethyl)piperazine-1-yl]ethoxy]phenyl}porphyrin (OMEPzEOPP)<8+>8I<-> (short for OMEPzEOPP) and a polypeptide nanometer carrier are combined, and the obtained material is used in preparation of a nanometer PDT photosensitizer capable of specifically recognizing tumor cells.

The invention relates to a method for preparing elsinochrome silicon dioxide nanoparticle with high photostability and fine water-solubility and an application thereof in preparing vein injection, comprising the following preparation steps: (1). hydrolyzing a single silane terpenoid or multiple silane terpenoids under alkaline conditions to generate nanometer silicon dioxide with a nuclear shell structure; (2). encapsulating elsinochrome in absence or in presence of surface active agents to prepare the elsinochrome silicon dioxide nanoparticle which suits vein injection, features relatively high photostability and fine water-solubility and has a particle diameter less than 200 nm; mole ratio relation between the reagents elsinochrome and silane ranges from 1:1 to 1: 10000. The photostability of the silicon dioxide nanoparticle is improved, photodegradation loss, preservation difficulty and preservation cost caused in the process of R&D, production and transportation and in use links are effectively reduced; moreover, the preparation method is simple, the operation is easy; furthermore, the capacity of active oxygen such as O2 is strengthened, the invisible toxicity is low and the optical toxicity is high.

Described herein are compounds for the detection, diagnosis, and treatment of specific diseased tissues, including hyper-proliferative tissues such as tumors, and other tissue diseased with microbial and/or infectious species, using energy-activation methods. In particular, compounds sensitive to externally applied energy, including light and/or ultrasound; that also specifically accumulate in diseased target tissue, are provided.

The invention relates to a preparation method for graphene oxide-TiO2-hypocrellin A three-component compound system and application thereof in photodynamic therapy. The preparation method for the three-component compound system comprises the steps of firstly, oxidizing graphite through strong oxidant and then washing the oxidized graphite through hydrochloric acid to obtain an aqueous solution of graphene oxide with an electronegative surface; secondly, obtaining an aqueous solution of surface positively charged TiO2 through a sol-gel method; thirdly, achieving effective compounding of the hypocrellin A and the graphene oxide through pi-pi interaction and intermolecular hydrogen bonds between the hypocrellin A and the graphene oxide, and achieving effective compounding of TiO2, the hypocrellin A and the graphene oxide in the aqueous phase through the electrostatic interaction between TiO2 and graphene oxide-hypocrellin A. According to the preparation method, the medicine carrying system is established at the room temperature, so that influence of the high temperature on activity of medicine is prevented; the obtained nanometer compound system is good in dispersity of aqueous phase, has a multiple sensitization mechanism, can improve the active oxygen generation capacity of hypocrellin A remarkably and is low in dark toxity and remarkably improved in phototoxicity compared with hypocrellin A.

The invention provides an iridium (III) complex and a preparation method and application thereof. The anti-tumor iridium (III) complex with a structure as shown in a formula (1) or a formula (2) in the invention can specifically target mitochondria or lysosome, has low dark toxicity and high phototoxicity, and has a very high phototoxicity index in tumor cells, particularly in non-small cell lung cancer cells Meanwhile, the anti-tumor metal iridium (III) complex can be used as a photosensitizer to participate in photodynamic therapy. Compared with a traditional photosensitizer, the anti-tumor metal iridium (III) complex has the advantages of being good in water solubility, high in light stability, low in dark toxicity and the like, and can realize integration of diagnosis and treatment.

Disclosed is a novel glycoconjugated chlorin derivative which is useful as a substance for photodynamic therapy, is stable, and can act a photosensitizer having high phototoxicity even when used in a small quantity. Also disclosed is a method of producing the derivative. Specifically disclosed are a S-glycosylated chlorin derivative represented by the following general formula (1) and a metal complex thereof. In the general formula (1), X¹ to X²⁰ independently represent a group selected from the group consisting of F—, sugar-S—, sugar-Z-S— and sugar-O-Z-S— and at least one among X¹ to X²⁰ represents a group selected from the group consisting of sugar-S—, sugar-Z-S— and sugar-O-Z-S— (wherein F represents a fluorine atom, Z represents an oxygen atom, Z represents a hydrocarbon group having 1 to 6 carbon atoms); and R⁵ and R⁶ independently represent a hydrogen atom or an organic group or may together form a ring.

The invention discloses an application of water-soluble cationic porphyrin in preparation of a PDT nano photosensitizer. According to the method, a water-soluble cationic porphyrin compound, namely tetraiodized 5,10,15,20-tetra[1-methyl-1-piperidylethoxyphenyl]porphyrin (TMPipEOPP) 4<+>.4I<-> (hereinafter referred to as TMPipEOPP), is combined with a novel DNA nano structure; wherein the product is applied to preparation of the nano PDT photosensitizer with good biocompatibility.

The invention discloses a polypyridine ruthenium complex. The complex has the structure shown in the formula I (the formula I can be seen in the description), wherein X- represents monovalent anions for balancing charges. The complex has high phototoxicity and low dark toxicity, can be well used for preparing photoactivation anti-tumor medicines, and can overcome the defect of the great toxic andside effects of traditional chemotherapy medicines. The invention further discloses a preparing method and application of the polypyridine ruthenium complex.