A kind of red carbon dot material, preparation method and application thereof

A carbon dot, red fluorescence technology, applied in the field of luminescent carbon nanomaterial preparation, can solve the problems of limited tissue penetration, low singlet oxygen yield, complex preparation process, etc. Highly toxic, simple to prepare effect

Active Publication Date: 2022-05-24
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Li et al. have developed porphyrin-based carbon dots with cytotoxic singlet oxygen generation and good water solubility, but this carbon dot emits green fluorescence, and green fluorescence emission is often interfered by biological autofluorescence, and tissue penetration is limited. Ge synthesized a red fluorescent carbon dot for photodynamic therapy, but its preparation process is quite complicated, and the singlet oxygen yield is only 0.27
Therefore, there are some deficiencies in these materials used for photodynamic therapy: 1) high biological toxicity and low quantum yield; 2) mostly short-wavelength emission, blue or green, and lack of long-wavelength emission carbon dots; 3) Poor photostability and low yield of singlet oxygen

Method used

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  • A kind of red carbon dot material, preparation method and application thereof
  • A kind of red carbon dot material, preparation method and application thereof
  • A kind of red carbon dot material, preparation method and application thereof

Examples

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Effect test

Embodiment 1

[0038] Weigh 0.5g of potassium dihydrogen phosphate and 0.01g of methylene blue powder into a 50mL beaker, add 15mL of ultrapure water, stir well, then transfer to a 20mL reaction kettle, and raise the oven temperature to 200°C for 8h reaction. Then, after cooling to room temperature, it was filtered through a 0.22 μm microporous membrane, and the filtrate was taken, and then dialyzed at 1000 Da for 24 h. Finally, the red fluorescent carbon dot powder is obtained by freeze-drying.

[0039] The transmission electron microscope (TEM) image of the obtained powder dissolved in ultrapure water is as follows figure 1 As shown, it shows that the carbon dots with a diameter of about 6.67 nm have obvious lattice fringes, indicating that the carbon dots are successfully prepared.

[0040] The obtained red carbon dots were tested for UV-visible absorption, such as figure 2 As shown, it is shown that the carbon dots have strong absorption at 280 nm and 590 nm, and still maintain strong...

Embodiment 2

[0048] Weigh 0.25g of sodium dihydrogen phosphate and 0.01g of methylene blue powder into a beaker, add 15mL of ultrapure water, stir well, then transfer to a reaction kettle, raise the oven temperature to 200°C for 8h reaction. Then, after cooling to room temperature, it was filtered through a 0.22 μm microporous membrane, and the filtrate was taken, and then dialyzed at 1000 Da for 24 h. Finally, the red carbon dot powder is obtained by freeze-drying.

Embodiment 3

[0050] Weigh 0.5g of potassium phosphate and 0.01g of methylene blue powder into a beaker, add 15mL of ultrapure water, stir well, then transfer to the reaction kettle, raise the oven temperature to 200°C and react for 8h. Then, after cooling to room temperature, it was filtered through a 0.22 μm microporous membrane, and the filtrate was taken, and then dialyzed at 1000 Da for 24 h, and freeze-dried to obtain red carbon dot powder.

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Abstract

The invention discloses a red carbon dot material, a preparation method and application thereof, and belongs to the technical field of preparation of luminous carbon nanometer materials. In the present invention, a specific carbon source and phosphate are dispersed in water for hydrothermal reaction to construct a singlet oxygen yield, high photostability, good water solubility, high phototoxicity, low dark toxicity, and in the phototherapy window. There are red fluorescent carbon dots with strong absorption within 600-1000nm, which can be widely used as photosensitizer in the preparation of photodynamic therapy cancer drugs, construction of drug delivery systems, fluorescence imaging, light-emitting devices and biosensing, etc., and has a very good market prospect.

Description

technical field [0001] The invention belongs to the technical field of preparation of luminescent carbon nanomaterials, and in particular relates to a red carbon dot material and a preparation method and application thereof. Background technique [0002] Photodynamic therapy (PDT) is becoming a promising tumor treatment method due to its advantages of non-invasiveness, few side effects, strong selectivity, and low drug resistance. In PDT, the photosensitizer is irradiated with light of a specific wavelength with O 2 The reaction occurs to generate reactive oxygen species (ROS), so as to achieve the purpose of killing cancer cells. Traditional photosensitizers usually have the disadvantages of high hydrophobicity, poor photostability, and low fluorescence quantum yield, which limit their development in the field of PDT, while ideal photosensitizers for photodynamic therapy should have the following characteristics: (1) Single-line High yield of state oxygen; (2) good photos...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C01B32/15C09K11/65B82Y20/00B82Y40/00A61K41/00A61K49/00A61K47/04A61P35/00
CPCC01B32/15C09K11/65B82Y20/00B82Y40/00A61K41/0057A61K49/0067A61K49/0019A61K47/02A61P35/00C01P2004/04C01P2004/64
Inventor 王婵徐雅兰宋启军陈月月
Owner JIANGNAN UNIV
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