Method for preparing medicament-nanometer calcium phosphate composite system taking fat soluble photosensitizer as framework and application of system in preparation of medicaments for photodynamic therapy

A nano-calcium phosphate and photodynamic therapy technology, applied in the field of photosensitizers, can solve the problems of poor water solubility and inconvenient drug loading, and achieve the effects of high water solubility, promoting effective transmission, and increasing drug loading.

Inactive Publication Date: 2011-09-28
NANJING NORMAL UNIVERSITY
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AI Technical Summary

Problems solved by technology

[0008] The purpose of the present invention is to provide a preparation method of a drug-nanometer calcium phosphate composite system with a fat-soluble photosensitizer as a skeleton, so as to overcome the inconvenient preparation of a medicament due to poor water solubility of the fat-soluble photosensitizer and the drug loading of the existing drug delivery system. Due to the disadvantage of small amount, construct a self-assembled drug delivery system of fat-soluble photosensitizer and nano-calcium phosphate with the self-assembled nanostructure of fat-soluble photosensitizer as the skeleton and nano-calcium phosphate as the skeleton support structure, and apply this method in the field of photodynamic therapy , that is, this application will provide a preparation method of a water-soluble drug-nanometer calcium phosphate drug delivery system with a fat-soluble photosensitizer as the backbone and its application in the preparation of intravenous injections for photodynamic therapy

Method used

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  • Method for preparing medicament-nanometer calcium phosphate composite system taking fat soluble photosensitizer as framework and application of system in preparation of medicaments for photodynamic therapy
  • Method for preparing medicament-nanometer calcium phosphate composite system taking fat soluble photosensitizer as framework and application of system in preparation of medicaments for photodynamic therapy
  • Method for preparing medicament-nanometer calcium phosphate composite system taking fat soluble photosensitizer as framework and application of system in preparation of medicaments for photodynamic therapy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] In the experimental system, 10 mL of distilled water, 500 μL of calcium chloride solution (0.25M), and 500 μL of 3-phosphorylpropionic acid aqueous solution (0.25M) were added successively to prepare A system by magnetic stirring; 10 mL of distilled water, 500 μL of HA solution (15 mM) and 500 μL disodium hydrogen phosphate aqueous solution (0.25M) were magnetically stirred evenly to prepare system B; after mixing system A and system B, the drug-nanocalcium phosphate composite system with hypocretin A as the skeleton was obtained ( HA-CaP) aqueous solution, freeze-dried to obtain the drug-nano-calcium phosphate composite system solid with hypocretin A as the skeleton.

[0035] Characterization of the drug-nanometer calcium phosphate composite system with hypocretin A as the backbone:

[0036] The morphology of the nanoparticles prepared in this example was observed with a transmission electron microscope. Photosensitivity of nanoparticles The morphology and nucleic aci...

Embodiment 2

[0042] It is basically the same as in Example 1, but the added amount of the HA solution is 20 μL-1 mL.

Embodiment 3

[0044] It is basically the same as in Example 1, but the amount of the calcium chloride solution added is 5 μL to 1 mL.

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Abstract

The invention discloses a method for preparing a medicament-nanometer calcium phosphate composite system taking a fat soluble photosensitizer as a framework, which comprises the following steps of: under the condition that phosphoryl-containing organic matters exist or do not exist, adding distilled water and aqueous solution of calcium salt, and stirring uniformly to prepare a system A; adding the distilled water and aqueous solution of phosphate, and stirring uniformly to prepare a system B; and adding fat soluble photosensitizer solution into the system A or the system B or adding the fat soluble photosensitizer solution into the systems A and B simultaneously, stirring uniformly, and mixing the system A and the system B to obtain the medicament-nanometer calcium phosphate composite system taking the fat soluble photosensitizer as the framework. The administration system prepared by the method is high in water solubility and dispersibility and can promote the effective transmission of the fat soluble photosensitizer in blood, and the medicine loading rate of the administration system is increased. Simultaneously, the preparation method is simple, easy to operate, high in stability and low in cost. The invention also relates to application of the administration system prepared by the method in the preparation of medicaments for photodynamic therapy.

Description

technical field [0001] The invention belongs to the technical field of photosensitizers with photodynamic activity, and relates to a preparation method of a drug-nanometer calcium phosphate composite system with a fat-soluble photosensitizer as a skeleton and its application in photodynamic therapy. Background technique [0002] Photodynamic therapy (PDT) is a new treatment method for various tumors, cardiovascular, skin and eye diseases. PDT is a new type of medical technology based on photodynamic reaction. The photosensitizer is injected into the patient's body, and after a period of time, after it is relatively enriched in the tumor tissue, the tumor is irradiated with light of an appropriate wavelength (usually laser). At this time, the photosensitizer enriched in the tumor tissue can trigger the photodynamic reaction to release reactive oxygen species, resulting in oxidative damage and free radical chain reaction, and finally lead to oxidative damage in the tumor tissu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K47/24
Inventor 周家宏魏少华周林冯玉英沈健
Owner NANJING NORMAL UNIVERSITY
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