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Method of producing water-solubility hypocrellin titanium dioxide nano granule

A technology of hypocrellin and titanium dioxide, which is applied in the field of photosensitizers, can solve the problems of inconvenient medicines and poor water solubility, and achieve the effects of simple preparation method, high water solubility, and elimination of phototoxic side effects

Inactive Publication Date: 2008-02-27
NANJING NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The object of the present invention is to overcome the shortcoming that hypocrellin is inconvenient to be made into medicament due to poor water solubility, and provides a method for preparing water-soluble hypocrellin titanium dioxide nanoparticles

Method used

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  • Method of producing water-solubility hypocrellin titanium dioxide nano granule
  • Method of producing water-solubility hypocrellin titanium dioxide nano granule
  • Method of producing water-solubility hypocrellin titanium dioxide nano granule

Examples

Experimental program
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Effect test

Embodiment 1

[0032] Prepare water-soluble hypocrellin A titanium dioxide nanoparticles by hydrolysis of tetraethyl titanate, the reaction system and conditions are as follows:

[0033] Add 1 mL of tetraethyl titanate, 15 mL of ethanol, 4 mL of acetic acid, and 2 mL of double-distilled water to the experimental system in sequence, and then slowly add the ethanol solution of hypocrellin A (0.4 mM / L) dropwise under the condition of magnetic stirring, and add Stirring was continued at room temperature for 24 hours after completion. After the reaction, 40 mL of double distilled water was added, and the pH value of the solution was adjusted to 7.0 with sodium hydroxide. Ethanol and some small molecular compounds produced in the reaction were removed by dialysis, and water-soluble hypocrellin A titanium dioxide nanoparticles were obtained by freeze-drying.

Embodiment 2

[0035] The water-soluble Hypocretin A titanium dioxide nanoparticles were prepared by hydrolysis of tetra-n-butyl titanate. The reaction system and conditions were as follows:

[0036] Add 1.5mL of tetra-n-butyl titanate, 15mL of ethanol, 4mL of acetic acid, 2mL of double distilled water into the experimental system in sequence, and then slowly add the ethanol solution of hypocrellin A (0.4mM / L) under the condition of magnetic stirring. After the addition was complete, stirring was continued at room temperature for 24 hours. After the reaction, 40 mL of double distilled water was added, and the pH value of the solution was adjusted to 7.0 with sodium hydroxide. Ethanol and some small molecular compounds produced in the reaction were removed by dialysis, and water-soluble hypocrellin A titanium dioxide nanoparticles were obtained by freeze-drying.

[0037] Characterization of water-soluble hypocrellin A nano-titanium dioxide nanoparticles:

[0038] The photochemical properties...

Embodiment 3

[0044] Preparation of Water-Soluble Hypocretin B Titanium Dioxide Nanoparticles by Hydrolysis of Tetraethyl Titanate, Reaction Body

[0045] Departments and conditions are as follows:

[0046] Add 1 mL of tetraethyl titanate, 15 mL of ethanol, 4 mL of acetic acid, and 2 mL of double-distilled water to the experimental system in sequence, then slowly add the ethanol solution (0.4 mM / L) of hypocrellin B dropwise under the condition of magnetic stirring, and add Stirring was continued at room temperature for 24 hours after completion. After the reaction was completed, 40 mL of double-distilled water was added, and the pH value of the solution was adjusted to 7.0 with sodium hydroxide. Ethanol and some small molecular compounds produced in the reaction were removed by dialysis, and water-soluble hypocrellin titanium dioxide nanoparticles were obtained by freeze-drying.

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Abstract

The invention discloses a preparing method of soluble bamboo bacterioruberin titanium oxide nanometer particle, which comprises the following steps: hydrolyzing organic titanium compound in the alcohol, acetic acid and distilled water; dripping the alcohol solution of bamboo bacterioruberin slowly; stirring; reacting to add the distilled water; adjusting the pH value of the solution to 7. 0; dialyzing to remove alcohol and small molecular compound; freezing; drying; obtaining the product; setting the weight rate of organic titanium compound and acetic acid at 1: 2-6; setting the weight rate of organic titanium compound and alcohol and distilled water at 1: 10-20: 1-3. The bamboo bacterioruberin is the bamboo bacterioruberin methyl, bamboo bacterioruberin ethyl or derivant of two compounds and the organic titanium compound is titanic acid tetraacetate, titanic acid tetra-n-propyl ester, tetraisopropoxy titanium, titanic acid tetera-n-butoyl or polytitanium acid butoyl. The invention has simple, easy and stable operation with diameter of soluble nanometer particle less than 150nm, which is beneficial to prepare and reserve the product.

Description

technical field [0001] The invention belongs to the technical field of photosensitizers with photodynamic activity, and relates to a preparation method of water-soluble hypocretin titanium dioxide nanoparticles. Background technique [0002] Photodynamic therapy (PDT) is a new type of tumor clinical therapy developed in recent years, and it is recognized as the fourth clinical treatment method for cancer besides chemotherapy, radiotherapy and surgery. Compared with traditional tumor treatment techniques, photodynamic therapy has unique advantages such as specific killing of tumor cells, low toxic and side effects, fewer postoperative complications, simultaneous use with radiotherapy and chemotherapy, and multiple uses. Especially for those patients with advanced cancer and who are not suitable for using traditional treatment techniques due to age, physical fitness and other reasons, photodynamic therapy is still an ideal treatment method, so this treatment method has been ad...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K9/19A61K31/122A61K47/04A61P35/00
Inventor 周家宏冯玉英魏少华宋开玺周林沈健
Owner NANJING NORMAL UNIVERSITY
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