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Preparation method for fat-soluble phtosensitizer nanoparticles and application thereof

A photosensitizer, fat-soluble technology, applied in the field of photosensitive drug nanometerization, can solve the problems of inability to administer intravenously, poor water solubility, etc., and achieve the effects of promoting effective transmission, low cost, and simple preparation method.

Inactive Publication Date: 2013-03-27
NANJING NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a method for preparing a fat-soluble photosensitizer self-assembled nano-medicine, to overcome the disadvantage that the fat-soluble photosensitizer cannot be given by intravenous injection due to poor water solubility, to construct a fat-soluble photosensitizer nano-medicine system, and to use the The method is applied in the field of photodynamic therapy, and the method can achieve the purpose of effectively transporting the fat-soluble photosensitizer in the blood

Method used

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  • Preparation method for fat-soluble phtosensitizer nanoparticles and application thereof
  • Preparation method for fat-soluble phtosensitizer nanoparticles and application thereof
  • Preparation method for fat-soluble phtosensitizer nanoparticles and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Add 10 mL of distilled water, 1.5 μL of ammonia water (28%), 50 μL of hypocrellin A in DMSO solution to the experimental system, and stir evenly to obtain system A; add 10 mL of distilled water, 1.5 μL of ammonia water (28%), 50 μL Sodium chloride aqueous solution (0.5M) was magnetically stirred to obtain system B; after mixing system A and system B, centrifuge at 16,000 rpm for 30 min, discard the supernatant, disperse the precipitate with distilled water, and repeat the above purification process 3 times. After freeze-drying, HA nanostructures that can be stably dispersed in the water phase can be obtained.

[0034] The morphology of the nanoparticles prepared in this example was observed with a transmission electron microscope. The photosensitizing activity of the nanoparticles was characterized using tumor cell topography analysis.

[0035] (1) Electron microscope observation of HA nanostructure

[0036]The size and shape of nanoparticles were observed by transmis...

Embodiment 2

[0040] Example 2 is basically the same as Example 1, but the added amount of the HA solution is 0.1 μL-1 mL.

[0041]

Embodiment 3

[0042] Example 3 is basically the same as Example 1, but the amount of ammonia water added is 0.1 μL to 1 mL.

[0043]

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Abstract

The invention discloses a preparation method for fat-soluble phtosensitizer nanoparticles. Under the condition that that the potential of hydrogen (pH) value is 1-14, a fat-soluble phtosensitizer or soluble inorganic salt is added into a reaction medium respectively to prepare A and B systems and the A system and the B system are mixed. Or, the fat-soluble phtosensitizer or soluble inorganic salt are simultaneously added into the reaction medium and then mixed. The fat-soluble phtosensitizer self-assembles to form a nanometer structure and the fat-soluble phtosensitizer nanoparticles are obtained after separation and purification. The fat-soluble phtosensitizer nanoparticles prepared by the method provided by the invention has high water-solubility and good dispersibility and can be steadily dispersed in water phase, so that the effective transmission of the fat-soluble phtosensitizer nanoparticles in blood is promoted. Meantime, the method has the advantages of simpleness, easiness in operation, high stability and low cost. The invention also relates to the application of the fat-soluble phtosensitizer nanoparticles prepared by the method in preparing photodynamic therapy medicine.

Description

technical field [0001] The invention belongs to the technical field of photosensitive drug nanometerization, and relates to a simple method for preparing a fat-soluble photosensitive drug into a nanostructure stably dispersed in an aqueous phase and an application thereof. Background technique [0002] Photodynamic Therapy (PDT), also known as Photoradiation Therapy (PRT), Photochemical Therapy (PCT), is a new technology that utilizes photodynamic reactions for disease diagnosis and treatment. At present, PDT is mainly used in the treatment of various tumors, cardiovascular, skin and eye diseases. The treatment process of PDT is based on the photodynamic reaction of the photosensitizer (Photosensitizer, PS). Irreversible damage occurs at the lesion site and destroys the lesion. Due to the advantages of strong activity, low toxicity and side effects, and few complications, PDT has become a very potential therapy for the treatment of tumors, cardiovascular diseases, skin and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/10A61K41/00A61K47/02A61P35/00A61P27/02A61P17/00A61P9/00
Inventor 周林周家宏魏少华杨超马菲
Owner NANJING NORMAL UNIVERSITY
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