2results about How to "Low dark toxicity" patented technology

The application discloses a MOF-based high-order multi-photon excitation fluorescent material and a preparation method and application thereof, relates to the technical field of multi-photon excitation fluorescent materials, and the preparation method comprises the following steps: 1) preparation of ZrTc; 2) preparation of Au NRs; 3) preparation of Au NR / ZrTc; and 4) preparation of Au NR / ZrTc@FA. The MOF-based high-order multi-photon excitation fluorescent material prepared by the application has good biocompatibility and low dark toxicity, can realize enhanced two / three-photon fluorescence imaging under near-infrared two-region laser irradiation, and can be applied to cancer cell specific targeting and deep tissue fluorescence imaging.

The application discloses a kind of tannin-based Mn-Fe diatomic metal polyphenol nano-carrier loaded hypocrellin B nano-assemblies and its preparation method and application.The nano-assemblies use tannin as ligand, by step coordination driven self-assembly strategy, first with Mn 2+ Forming pre-assembly template, then introducing Fe 3+ Constructing Mn-Fe diatomic metal polyphenol network with atomic level uniform dispersion, and loading traditional Chinese medicine source photosensitizer hypocrellin B to obtain nano-preparation.The preparation realizes Fe 2+ / Fe 3+ Self-circulation, and can sustainably catalyze H2O2 in tumor microenvironment to generate hydroxyl radical, realizes long-acting chemical kinetics treatment;Meanwhile, in-situ oxygen production relieves tumor hypoxia, improves photodynamic therapy effect, and consumes glutathione to amplify oxidative stress.The preparation process of the application is mild, and biocompatibility is good, and it breaks through the bottleneck of insufficient effect of traditional treatment in anoxic tumor.