Novel metal iridium complex and preparation method and application thereof

A technology of complexes and metal iridium, which is applied in pharmaceutical formulations, indium organic compounds, platinum group organic compounds, etc., can solve limited problems and achieve the effect of strong phototoxicity and low dark toxicity

Active Publication Date: 2019-10-25
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Patents CN201611181323.0, CN201710396909.7 and CN201810342098.7 all disclose metal iridium complexes for photodynamic therapy of tumors, but at present, the iridium complexes for photodynamic therapy of tumors are still limited, and further preparation of more Iridium complexes for tumor photodynamic therapy for clinical selection
At present, there are no related reports on metal iridium complexes with photocatalytic oxidation for NADH

Method used

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  • Novel metal iridium complex and preparation method and application thereof
  • Novel metal iridium complex and preparation method and application thereof
  • Novel metal iridium complex and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] The preparation method of embodiment 1 ligand and complex

[0052] 1. Ligand synthesis method

[0053] (1) Mix 5,5'-dimethyl-2,2'-bipyridine (0.146g, 0.8mmol) with N-bromosuccinimide (0.313g, 1.76mmol) and azobisisobutyronitrile (0.328g, 2mmol) was heated to 80°C in carbon tetrachloride (20mL) for bromination reaction to generate 0.200g 5,5'-dibromomethyl-2,2'-bipyridine (0.585mmol), producing The rate is 73.1%; the above chemical reaction equation is as follows:

[0054]

[0055] (2) Add 1.0 mL (5.0 mmol) of trimethylamine to the ethanol solution of 5,5'-dibromomethyl-2,2'-bipyridine (0.200 g, 0.585 mmol) generated in step (1), 0.252 g of white powder was obtained, yield 86.8%. Characterized by mass spectrometry and NMR, the product is 5,5'-bis(trimethylaminomethyl)-2,2'-dipyridine dibromide, and its molecular formula is C 18 h 28 N 4 Br 2 2H 2 O(496.29); the above chemical reaction equation is as follows:

[0056]

[0057] Mass spectrum: ESI-MS, m / z (%)...

Embodiment 2

[0074] The preparation of a metal iridium (III) complex is basically the same as in Example 1, except that in step 2-(1), the reaction temperature is 115°C and the reaction time is 26 hours; step 2-(2) , the reaction temperature was 140°C, and the reaction time was 22 hours.

Embodiment 3

[0076] The preparation of a metal iridium (III) complex is basically the same as in Example 1, except that in step 2-(1), the reaction temperature is 113°C and the reaction time is 28 hours; step 2-(2) , the reaction temperature was 145°C, and the reaction time was 20 hours.

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Abstract

The invention discloses a novel metal iridium (III) complex. The chemical structural formula of the metal iridium (III) complex is shown in a formula (I); and the metal iridium (III) complex has no toxicity to tumor cells and normal cells in the dark, but has strong growth inhibition ability to the tumor cells under light conditions, has a photo-catalytic oxidation effect on NADH, and is of greatsignificance to the study of a high-efficiency and low-toxicity iridium complex photosensitizer, anti-tumor drugs can further be prepared, and great application prospects are achieved.

Description

technical field [0001] The present invention relates to the technical field of photodynamic therapy drugs, and more specifically relates to a novel metal iridium complex and its preparation method and application. Background technique [0002] About 8.8 million people die of cancer every year in the world, accounting for nearly one-sixth of the total death toll. Every year, 14 million cancer patients are diagnosed worldwide. In my country, about 2.2 million people die of cancer every year, and the trend is gradually increasing every year. Nasopharyngeal carcinoma refers to malignant tumors that occur on the top and side walls of the nasopharyngeal cavity. [0003] Radiation therapy is the first choice for the treatment of nasopharyngeal carcinoma, but the side effects such as myelosuppression, gastrointestinal reactions, and hair loss caused by radiotherapy have greatly reduced the quality of life of many patients. Photodynamic therapy is considered to be a new tumor treatm...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F15/00C09K11/06A61K31/555A61K41/00A61P35/00
CPCA61K41/0057A61P35/00C07F15/0033C09K11/06C09K2211/185
Inventor 黄怀义黄灿
Owner SUN YAT SEN UNIV
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