Drug-loaded nanoparticles for targeted immunotherapy of pancreatic cancer and its application

A nanoparticle and pancreatic cancer technology, applied in gene therapy, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of limited in vivo application and lack of effective carriers
CN105169402BInactive Publication Date: 2018-03-16SUN YAT SEN MEMORIAL HOSPITAL SUN YAT SEN UNIV +4
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SUN YAT SEN MEMORIAL HOSPITAL SUN YAT SEN UNIV
Publication Date
2018-03-16
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention provides a targeting carrier for treating pancreatic cancer, which includes: CD44v6 single-chain antibody for targeted recognition of pancreatic cancer cells, and nanocarrier IONP-PEI; wherein CD44v6 single-chain antibody and nanocarrier IONP-PEI PEI-coupled. In another aspect, the present invention provides a nanoparticle for treating pancreatic cancer, which includes the aforementioned targeting carrier, silencing RNA, and gemcitabine chemotherapeutic drug, wherein the silencing RNA and gemcitabine are complexed on the aforementioned targeting carrier. The invention constructs a non-viral gene carrier with high efficiency, safety and targeting function. Coupling silencing RNA and gemcitabine through nanocarriers and anti-CD44v6 single-chain antibody, combining gene therapy, chemotherapy and biological targeted therapy, provides new ideas and scientific basis for the development of new anti-pancreatic cancer drugs.
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Description

technical field

[0001] The present invention relates to targeting vectors, nanoparticles and applications thereof for the treatment of pancreatic cancer Background technique

[0002] Pancreatic cancer is one of the common malignant tumors of the digestive tract, which has the characteristics of insidious onset, easy metastasis, and low long-term survival rate. Radical surgical resection is the first choice for the treatment of pancreatic cancer, but most pancreatic cancer patients are diagnosed at an advanced stage, and the surgical resection rate is <20%. Chemotherapy is the main treatment, but due to the existence of tumor chemotherapy drug resistance, chemotherapy drugs are not effective It is very ideal, and it is an urgent clinical problem to develop new drugs to treat pancreatic cancer more effectively. Since 1997, gemcitabine has been the first-line drug for clinical anti-pancreatic cancer treatment, but no breakthrough has been made in terms of long-term efficacy...

Claims

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