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Digestion tolerant starch and its preparation method and uses

A technology of anti-digestible starch and starch, which is applied in the direction of pharmaceutical formulations, medical preparations of non-active ingredients, fermentation, etc., can solve problems that have not been reported before, and achieve industrial production, low development costs, and good social and economic benefits. Effect

Active Publication Date: 2004-11-17
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there is no report on the use of digestible starch as a controlled-release carrier for oral colon-targeted drugs

Method used

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  • Digestion tolerant starch and its preparation method and uses

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Add 185 grams of water to 815 grams of cornstarch (moisture content is 14.2%) in the mixer, make the material moisture content reach 30%, fully mix; Heat to 90 ℃ in airtight state, constantly stir and keep 30min, the material After cooling down to room temperature in the mixer, take it out, use 5000U / g starch heat-resistant α-amylase at pH 6.0, temperature 100°C for 0.5h, then use 300U / g starch at pH 4.0, temperature 50°C The glucoamylase was fully enzymatically hydrolyzed for 1h; the enzymolyzed product was centrifuged, washed, filtered, dried, and crushed to obtain resistant starch RS1 # .

Embodiment 2

[0029] Add 26.3 grams of water to 500 grams of high-chain corn starch (moisture content is 15.8%) in the mixer to make the material moisture content reach 20%, fully mix and seal for 24 hours, put into 4520PST high-temperature pressure reaction kettle (PARR company in the United States) During the process, adjust the temperature to 120°C, control the pressure at 0.7MPa, and keep the reaction conditions stable for 2 hours. After the material is cooled to room temperature in the mixer, it is taken out and dried in an electric constant temperature blast drying oven at 50°C to obtain anti-digestion Starch RS2 # .

Embodiment 3

[0031] Add 89.6 grams of water to 600 grams of mung bean starch (moisture content is 16.1%) in mixer, make material moisture content reach 27%, fully mix and seal and place 24h, put into 4520PST high-temperature pressure reaction kettle (U.S. PARR company), Adjust the temperature to 110°C, control the pressure at 1MPa, and keep the reaction conditions stable for 1 hour. After the material is cooled to room temperature in the mixer, take it out, and use 8000U / g starch heat-resistant α-amylase at pH 6.0 and temperature 100°C Under the action of 0.5h, then fully enzymolyzed with 300U / g starch glucoamylase at pH 4.5 and temperature 60°C for 1h; the enzymolyzed product was centrifuged, washed, dried and pulverized in an electric heating constant temperature blast drying oven at 50°C Resistant starch RS3 # .

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Abstract

The invention discloses an alimentary resistant starch, the process for preparing the starch, and the use of the starch in preparing oral administration colon targeting medicament control release vectors, wherein the starch preparing process comprises the steps of, (1) mixing the starch with water, (2) heavy pressure modifying the starch or starch milk, (3) reacting in a reactor, (4) subjecting the enzymolysis product yield to centrifugation, scouring, filtering, drying and disintegration.

Description

technical field [0001] The invention relates to an anti-digestion starch and a preparation method thereof, and also relates to the application of the anti-digestion starch as an oral colon-targeting drug controlled release carrier. Background technique [0002] Oral colon-targeted drug delivery technology is not only convenient to use and easy to accept by patients, but also the drug can be dispersed throughout the colon at a high concentration, which is extremely beneficial to the absorption of drugs and the treatment of diseases. Preparation and development of excellent and ideal drug carriers is one of the key technologies in order to successfully deliver drugs through oral colon targeting and the characteristics of drug release. [0003] At present, the researched colon-targeting drug carriers mainly include: pH-dependent, time-dependent and colon-specific flora-degrading types (aromatic azo polymers and polysaccharides containing glycosidic bonds). Since the pH value ...

Claims

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Application Information

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IPC IPC(8): A61K47/36C08B30/00C12P19/14
Inventor 陈玲李琳李晓玺李冰黎锡流郭祀远胡松青
Owner SOUTH CHINA UNIV OF TECH
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