Nano particles compounded of up-conversion nano particles and gold nanorods and preparation method and application of nano particles
A technology of nanoparticles and gold nanorods, which is applied in the field of nanobiomedicine to achieve the effect of small side effects, broad treatment prospects and remarkable curative effect
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 The present invention firstly provides a preparation method of nanoparticles composited with upconversion nanoparticles and gold nanorods, comprising:
 Reaction of upconverting core-shell nanoparticles with photosensitizer, and then with SiO 2 The coated gold nanorods are subjected to a coupling reaction to obtain composite nanoparticles of upconversion nanoparticles and gold nanorods; the SiO 2 The thickness of the coated gold nanorod shell is 30-60nm.
 According to the present invention, the preparation method of the up-conversion core-shell nanoparticles is a commonly used method in the art, without special limitations, the specific preparation method can refer to the literature Monodisperse silica-coated polyvinylpyrrolidone / NaYF 4 nanocrystals with multicolor upconversion fluorescence emission, Angew.Chem.Int.Ed, 2006, 45, 7732-7735. and literature Synthesis of hexagonal-phase core-shell NaYF 4 Nanocrystals with tunable upconversion fluorescence, ...
 1. Prepare up-conversion NaYF by high-temperature pyrolysis 4 : Yb, Er nanoparticles (reference Monodisperse silica-coated polyvinylpyrrolidone / NaYF 4 nanocrystals with multicolor upconversion fluorescence emission, Angew. Chem. Int. Ed, 2006, 45, 7732-7735.). First, weigh the total amount of yttrium chloride YCl 3 ·6H 2 O236.8mg, ytterbium chloride YbCl 3 ·6H 2 O77.5mg, erbium chloride ErCl 3 ·6H 2 O76.3mg, weigh the quality, put it into a 50mL three-necked bottle, add 4mL oleic acid and 17mL1-octadecene. After stirring for half an hour to deoxygenate, heat up the temperature. After the medicines are dissolved, stop heating, cool to room temperature, and add 0.1gNaOH and 0.1482gNH 4 F in methanol solution, then heated up to 60°C and kept for 30min. Then keep at 75°C for 45min. The temperature was then raised to 300°C and held for 1.5 hours. After the reaction is finished, centrifuge with acetone and ethanol respectively, and the finally obtained up-conversion...
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