Preparation method of metal ruthenium nano material and anti-tumor medicine

A nanomaterial, metal ruthenium technology, applied in the field of nanomaterials, can solve the problems of complex synthesis, poor water solubility, etc., and achieve the effects of simple synthesis method, strong light stability, and high fluorescence quantum yield

Active Publication Date: 2019-04-12
WUHAN INSTITUTE OF TECHNOLOGY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] In view of this, the present invention aims to propose a method for preparing metal ruthenium nanomaterials to solve the problems of poor water solubility and complex synthesis of existing metal ruthenium nanomaterials

Method used

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  • Preparation method of metal ruthenium nano material and anti-tumor medicine
  • Preparation method of metal ruthenium nano material and anti-tumor medicine
  • Preparation method of metal ruthenium nano material and anti-tumor medicine

Examples

Experimental program
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Embodiment 1

[0038] A kind of preparation method of metal ruthenium nano material, it specifically comprises the following steps:

[0039] 1) Dissolve 10 mg of the metal ruthenium complex in aqueous citric acid solution, and perform ultrasonic dispersion to obtain a mixed solution A, wherein the metal ruthenium complex is composed of 5-amino-1,10-phenanthroline and ruthenium trichloride The mass of citric acid in citric acid aqueous solution is 2.0g, the volume of water is 20mL; the dispersion time of ultrasonic dispersion is 20min, at this time, the mass ratio of metal ruthenium complex to citric acid is 1:200, in citric acid aqueous solution The mass concentration of citric acid is 0.1g / mL, and the mass concentration of citric acid in the citric acid aqueous solution refers to the mass concentration of citric acid in water, that is, the quality of citric acid in the citric acid aqueous solution is divided by the volume of water in the citric acid aqueous solution;

[0040] 2) Heat the mi...

Embodiment 2

[0044] The difference between this example and Example 1 is that the amino-containing polypyridine ligand is 2-amino-1,10-phenanthroline.

Embodiment 3

[0046] The difference between this example and Example 1 lies in that the amino group-containing polypyridine ligand is 2,2'-bipyridine-4,4'-diamine.

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Abstract

The invention provides a preparation method of a metal ruthenium nano material. The preparation method comprises the following steps that 1, a metal ruthenium complex is dissolved in a polycarboxyliccompound aqueous solution, and ultrasonic dispersion is carried out to obtain a mixed solution A, wherein the metal ruthenium complex is formed by coordination of a polypyridine ligand containing amino and ruthenium trichloride; 2, water bath heating is carried out on the mixed solution A to obtain a reaction solution B; 3, the pH value of the reaction solution B is adjusted by using an alkaline reagent, then supernate of the reaction solution B is dialyzed, an aqueous solution obtained through dialysis is collected and freeze-dried, and the metal ruthenium nano material is obtained. Accordingto the preparation method of the metal ruthenium nano material, protonation of amino and a hydrothermal method are used, the metal ruthenium complex difficult to dissolve in water is wrapped with thewater-soluble polycarboxylic compound, so that the prepared metal ruthenium nano material is good in water solubility, high in light stability, relatively high in fluorescence quantum yield, high intumor photodynamic therapy, good in biocompatibility and high in singlet oxygen yield.

Description

technical field [0001] The invention relates to the technical field of nanomaterials, in particular to a preparation method of metal ruthenium nanomaterials and antitumor drugs. Background technique [0002] Cancer has become one of the diseases with the highest death rate in the world today. After years of exploration, scientists discovered that metal platinum has targeting and phototoxicity to tumor cells, and began to enter people's sight as an anti-tumor drug, and as one of the most widely used drugs in the clinical treatment of testicular cancer, ovarian cancer, head and neck tumors, etc. , but its toxic and side effects are also very obvious, such as nephrotoxicity, bone marrow toxicity, ototoxicity, peripheral neurotoxicity, emetic and drug resistance caused by long-term use, etc., and it does not work for many tumors, making its application restricted limit. This has prompted some researchers to turn their attention to the development of non-platinum metal anticanc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F15/00C09K11/06A61K31/555A61K41/00A61P35/00
CPCA61K41/0057A61P35/00C07F15/0053C09K11/06C09K2211/185
Inventor 吴风收乐亮亮朱思哲王凯孙琦
Owner WUHAN INSTITUTE OF TECHNOLOGY
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