Gadolinium coordination polymer network microsphere and application thereof to magnetic resonance imaging

A technology of coordination polymers and polymers, which is applied in the fields of nuclear magnetic resonance/magnetic resonance imaging contrast agents, drug delivery, and pharmaceutical formulations. It can solve problems such as low relaxation rate, high manufacturing cost, and complicated preparation methods of contrast agents. Achieve the effects of simple synthesis conditions, low cost of raw materials, and high potential application value

Inactive Publication Date: 2018-08-24
武汉佰强生物医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In view of the above problems, the present invention provides a gadolinium coordination polymer network microsphere and its preparation method and application to solve the problems of complex preparation methods, high manufacturing costs and low relaxation rate of contrast agents in the prior art

Method used

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  • Gadolinium coordination polymer network microsphere and application thereof to magnetic resonance imaging
  • Gadolinium coordination polymer network microsphere and application thereof to magnetic resonance imaging
  • Gadolinium coordination polymer network microsphere and application thereof to magnetic resonance imaging

Examples

Experimental program
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Effect test

Embodiment 1

[0024] 1. Weigh 2.63g of gadolinium chloride and 2.16g of acrylic acid and dissolve them in 50ml of deionized water. 2 Mix and stir under atmosphere for 20min;

[0025] 2. Add 0.2g of potassium persulfate to the uniformly stirred solution, continue to stir for 10 minutes, and heat the water bath for the next heating to 80°C;

[0026] 3. The solution obtained in 2 was placed in a water bath at 80° C. and stirred for 2 hours, and then the obtained emulsion was dialyzed to finally obtain gadolinium-coordinated polymer network microspheres.

Embodiment 2

[0028] 1. Weigh 2.63g of gadolinium chloride and 2.88g of acrylic acid and dissolve them in 50ml of deionized water. 2 Mix and stir under atmosphere for 20min;

[0029] 2. Add 0.2g of potassium persulfate to the uniformly stirred solution, continue to stir for 10 minutes, and heat the water bath for the next heating to 80°C;

[0030] 3. The solution obtained in 2 was placed in a water bath at 80° C. and stirred for 2 hours, and then the obtained emulsion was dialyzed to finally obtain gadolinium-coordinated polymer network microspheres.

Embodiment 3

[0032] 1. Weigh 2.63g of gadolinium chloride and 3.60g of acrylic acid and dissolve them in 50ml of deionized water. 2 Mix and stir under atmosphere for 20min;

[0033] 2. Add 0.2g of potassium persulfate to the uniformly stirred solution, continue to stir for 10 minutes, and heat the water bath for the next heating to 80°C;

[0034] 3. The solution obtained in 2 was placed in a water bath at 80° C. and stirred for 2 hours, and then the obtained emulsion was dialyzed to finally obtain gadolinium-coordinated polymer network microspheres.

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Abstract

The invention discloses a gadolinium coordination polymer network microsphere and application thereof to magnetic resonance imaging and belongs to the field of material science and biomedical application. The coordination polymer network microsphere is of a net-shaped crosslinking structure; specifically, after an acrylic monomer is coordinated with gadolinium ions, the net-shaped cross-linked gadolinium coordination polymer network microsphere is formed through coordination and free radical polymerization. A preparation method of the polymer microsphere is simple and the cost is low; the polymer microsphere has a stable structure and has a relatively high relaxation rate, a relatively good T1 imaging effect and long blood circulation time; the polymer microsphere has extremely great potential application value in the aspects of diagnosis and treatment of cancers and tumors.

Description

technical field [0001] The invention belongs to the field of material science and biomedicine, in particular to a gadolinium-containing coordination polymer network microsphere and its application in magnetic resonance imaging. Background technique [0002] At present, the MRI contrast agents used clinically are mainly some small molecule gadolinium-containing complexes and superparamagnetic ferric oxide. Low, failed to achieve the ideal contrast effect, so its clinical application is limited. In order to solve the shortcomings of small molecule contrast agent materials, increase the contrast agent contrast time, prolong the circulation time of contrast agent materials in the blood, and increase the relaxation rate while reducing the amount of contrast agent, a large number of workers focus on small molecule contrast agent Modification and multi-functionalization of , and preparation of inorganic nanoparticle contrast agents. However, when modifying small molecules, most o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/08A61K49/12A61K49/18C08G83/00
CPCA61K49/085A61K49/12A61K49/1818C08G83/008
Inventor 肖强徐祖顺喻春函
Owner 武汉佰强生物医药有限公司
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