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Rare earth-based nanoparticle magnetic resonance contrast agent and preparation method thereof

A magnetic resonance contrast agent and nanoparticle technology, applied in the field of nanomaterials, can solve problems such as long cycle time, achieve good repeatability, reduce the possibility of dissociation, and reduce the effect of relaxation time

Inactive Publication Date: 2014-09-17
PEKING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And because the size of nanoparticles is larger than that of chelates, the circulation time in the body is longer

Method used

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  • Rare earth-based nanoparticle magnetic resonance contrast agent and preparation method thereof
  • Rare earth-based nanoparticle magnetic resonance contrast agent and preparation method thereof
  • Rare earth-based nanoparticle magnetic resonance contrast agent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Gd 2 o 3Synthesis of nanoparticles: Add 0.5 mmol gadolinium acetylacetonate to a mixed solvent of oleic acid (4 mL) and oleylamine (12 mL), heat to 340 ° C under the protection of an inert gas, maintain the temperature for 15 min, cool the reaction solution to room temperature, and A large amount of ethanol was added to it, centrifuged and washed twice to obtain Gd 2 o 3 nanoparticles.

Embodiment 2

[0038] PR 2 o 3 Synthesis of nanoparticles: Add 0.5 mmol praseodymium acetate to a mixed solvent of oleic acid (6 mL) and oleylamine (12 mL), heat to 340 °C under the protection of an inert gas, maintain the temperature for 2 h, cool the reaction solution to room temperature, and add Add a large amount of ethanol, centrifuge and wash twice to get Pr 2 o 3 nanoparticles.

Embodiment 3

[0040] Er 2 o 3 Synthesis of nanoparticles: Add 0.5 mmol of erbium phenylacetylacetonate to a mixed solvent of oleic acid (6 mL) and oleylamine (8 mL), heat to 310 ° C under the protection of an inert gas, maintain the temperature for 1 h, and cool the reaction solution to room temperature , add a large amount of ethanol to it, centrifuge and wash twice to get Er 2 o 3 nanoparticles.

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Abstract

The invention relates to a rare earth-based nanoparticle magnetic resonance contrast agent and a preparation method thereof. The rare earth-based nanoparticle magnetic resonance contrast agent are rare earth-based inorganic nanoparticles having the surface coated with a hydrophilic ligand, firstly rare earth-based nanoparticles are obtained through a high-temperature oil phase reaction, and then the surface is coated with hydrophilic molecules to obtain the rare earth-based nanoparticle magnetic resonance contrast agent. Compared with a conventional clinical contrast agent, the magnetic resonance contrast agent has the relaxation rate greatly improved, is good in imaging effect, low in required injection dose, and relatively long in time staying in a body. In addition, a rigid structure of the inorganic nanoparticles can effectively reduce the free possibility of gadolinium ions. The rare earth-based nanoparticle magnetic resonance contrast agent has the advantages of simple preparation method, good repeatability and stable property, and easily realizes clinical commercial applications.

Description

technical field [0001] The invention relates to a rare earth-based nanoparticle magnetic resonance contrast agent and a preparation method thereof, belonging to the technical field of nanomaterials. Background technique [0002] Magnetic Resonance Imaging (MRI) is an important technology in the field of medical diagnosis and molecular imaging, which has the advantages of high tissue resolution, multiple imaging parameters, and no radiation damage to the human body. However, due to the low sensitivity of MRI technology, contrast agents (Contrast Agents) are often used clinically to improve imaging contrast and image quality. Contrast agents can be divided into two categories according to the ratio of transverse and longitudinal relaxation rates: T that brightens local tissues 1 Contrast agents and T that darken localized tissue 2 contrast agent. Rare earth ions have unfilled 4f electron shells, so they have unique optical, electrical, and magnetic properties. 1 with T 2 ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/18A61K49/08
CPCA61K49/08A61K49/1836A61K49/1854A61K49/1857A61K49/10A61K49/126A61K49/1806A61K49/1824
Inventor 孙聆东严纯华郑晓宇
Owner PEKING UNIV
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