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Novel nanometer material contrast agent and application thereof

A technology of nanomaterials and contrast agents, applied in the field of nanomaterials of Prussian blue, can solve the problems of only injectable, not oral, and achieve the effect of small side effects, significant effect and wide use.

Inactive Publication Date: 2013-12-18
顾世海
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, at present, all such agents cannot be taken orally, and can only be injected

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] The preparation of embodiment 1 nanometer material A

[0020] Ga 3+ +Gd 3+ +[Fe II (CN) 6 ] 4- + carboxylic acid = nanomaterial A

[0021] Under the condition of citric acid, synthesis containing gadolinium (Gd 3+ ) element Prussian blue nanomaterials: slowly add 20 ml of a mixture of gallium trichloride and gadolinium trichloride (9:1 molar ratio) and 0.5 millimolar citric acid with a concentration of 1.0 millimolar The same molar potassium ferrocyanide K 4 [Fe(CN) 6 ] and 0.5 mmol of citric acid, the solution was vigorously stirred at room temperature for 3 minutes, centrifuged, washed 3 times with a mixture of water and acetone (30:70V / V), and the desired nano Material. The cube microstructure (Fm3m class) was obtained by X-ray diffraction. According to the electron microscope analysis, it is a very ordered cubic sheet structure, and the pore size distribution is very concentrated. The average nanopore diameter is about 14 nanometers. Nano.

Embodiment 2

[0022] The preparation of embodiment 2 nanometer material B

[0023] Ga 3+ +Gd 3+ +[Fe III (CN) 6 ] 3- + carboxylic acid = nanomaterial C

[0024] Under the condition of citric acid, synthesis containing gadolinium (Gd 3+ ) element Prussian blue nanomaterials: 20 milliliters of a mixture of gallium trichloride and gadolinium trichloride (molar ratio of 6:4) and 0.5 millimoles of citric acid with the same molar concentration of 1.0 millimoles Potassium ferricyanide K 3 [Fe(CN) 6 ] and 0.5 millimolar of citric acid were slowly mixed in the dark, and then exposed to sunlight for 30 minutes, the nanomaterials gradually formed, and the solution changed from light green to dark blue in 5 to 10 minutes, centrifuged, and After washing with a mixture of water and acetone (30:70 V / V) for 3 times, the desired nanomaterial was obtained. Its microstructure is very similar to A.

Embodiment 3

[0025] The preparation of embodiment 3 nanometer material C

[0026] Fe 2+ +Gd 3+ +[Fe III (CN) 6 ] 3- + carboxylic acid = nanomaterial B

[0027] Under the condition of citric acid, synthesis containing gadolinium (Gd 3+ ) elemental Prussian blue nanomaterials: 20 milliliters of ferric chloride and gadolinium trichloride (molar ratio of 5:5) and 0.5 millimoles of citric acid were added slowly The same molar potassium ferricyanide K 3 [Fe(CN) 6 ] and 0.5 mmol of citric acid, the solution was vigorously stirred at room temperature for 3 minutes, centrifuged, washed 3 times with a mixture of water and acetone (30:70V / V), and the desired nano Material. Its microstructure is very similar to A.

[0028] Containing gadolinium (Gd) of the present invention 3+ ) element Prussian blue nanomaterials have a wide variety of uses, such as molecular and cell tracking probes in spectroscopy, contrast agents for nuclear magnetic resonance, etc.

[0029] The following examples are ...

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PUM

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Abstract

Since the commonly used nuclear magnetic resonance contrast agent containing gadolinium (Gd<3+>) element shall leaks metal gadolinium under certain conditions to bring toxicity to human body, the toxicity may can be fatal to patients with renal failure in particular, so that the problem of developing a new generation of stable and non-toxic contrast agents is urgent to be solved by pharmaceutical enterprises in the whole world. A Prussian blue nanometer material contrast agent containing gadolinium (Gd<3+>) element is synthesized in the invention through the latest development of nanotechnology, which comprises a synthesis method, material characteristics, contrast effect, and the like; and compared with the commonly used contrast agent containing gadolinium (Gd<3+>) element, the novel nanometer material contrast agent provided by the invention has the advantages of non-toxicity, high efficiency, low cost, and the like, thereby having a broad application prospect.

Description

technical field [0001] The present invention relates to a kind of novel nanometer compound and its application in contrast, specifically, the present invention relates to a kind of compound containing gadolinium (Gd 3+ ) element Prussian blue nanomaterials, which are suitable for human organ tissue imaging and drug delivery applications. Background technique [0002] In the past 20 years, with the continuous advent of high-end, precise and cutting-edge diagnostic equipment, the continuous improvement of medical diagnostic imaging technology has promoted the development of the contrast agent market. In 2000, the sales of 10 contrast agents among the top 400 best-selling drugs in the world were only US$1.611 billion, and now they have reached more than US$3 billion. Among them, the main representative contrast agents are iohexol and gadodiamide. Since magnetic resonance imaging does not use harmful radioactive sources such as X-rays and radiation, this imaging technology is c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01C3/12B82Y40/00A61K49/10
Inventor 顾世海
Owner 顾世海
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