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Method for preparing microcapsule coated microvesicle ultrasonic contrast medium

A technology of ultrasound contrast agent and microcapsule, which is applied in the direction of echo/ultrasound imaging agent, etc., which can solve the problems of disappearance and unstable acoustic properties of microbubble contrast agents, and achieve the effects of preventing dispersion, improving weak bonding, and good acoustic performance

Inactive Publication Date: 2008-07-16
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve the problem of the instability of microbubble contrast agents and the disappearance of acoustic properties after microbubbles are modified, the present invention provides a preparation method of microbubble ultrasonic contrast agents coated with microcapsules

Method used

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  • Method for preparing microcapsule coated microvesicle ultrasonic contrast medium
  • Method for preparing microcapsule coated microvesicle ultrasonic contrast medium

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specific Embodiment approach 1

[0015] Specific Embodiment 1: The microbubble ultrasonic contrast agent coated with microcapsules in this embodiment is prepared as follows: add microbubbles with a negative charge on the surface to a concentration of 0.001-1000 mg / mL and a volume of microbubble volume 1 ~100 times, positively charged bioactive material solution is adsorbed for 0.5~100min, left standing or centrifuged, and the upper layer of microbubbles is washed with normal saline or PBS buffer solution with a pH value of 7.0~8.0, and then added to a concentration of 0.001~ 1000mg / mL, 1-100 times the volume of microbubbles, and negatively charged bioactive material solution for 0.5-100min, let stand or centrifuge, and then wash the upper layer of microbubbles with normal saline or PBS with a pH value of 7.0-8.0 Washing with buffer solution; the microbubble ultrasound contrast agent coated with microcapsules is obtained.

[0016] The surface of the microbubble ultrasound contrast agent coated with microcapsul...

specific Embodiment approach 2

[0017] Embodiment 2: The difference between this embodiment and Embodiment 1 is that the microbubbles in step 1 are contrast agent microbubbles based on surfactants, or encapsulated with proteins, polymer materials, lipids or carbohydrates. Membrane contrast agent microbubbles. Others are the same as in the first embodiment.

specific Embodiment approach 3

[0018] Embodiment 3: The difference between this embodiment and Embodiment 1 is that the positively charged bioactive material in step 1 is one of polyelectrolytes, drugs, bioactive factors, DNA sequences, and targeting ligands or a combination of several. Others are the same as in the first embodiment.

[0019] In this embodiment, the positively charged bioactive material is composed of two or more substances and mixed in any ratio.

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Abstract

A preparation method of a micro bubble ultrasound contrast agent coated by a microcapsule relates to a preparation method of a micro bubble ultrasound contrast agent. The invention solves the problems of the instability of a micro bubble contrast agent and the disappearance of acoustic characteristic of a modified micro bubble. The preparation method of the micro bubble ultrasound contrast agent is that: absorbing, standing or centrifuging, cleaning, absorbing once again, standing or centrifuging and cleaning once more; finally the micro bubble ultrasound contrast agent is available. The invention has simple process, mild reaction condition, simple operation, good reproducibility, wild range of application and environment-friendliness, and is applicable to the surface modification of various ultrasound contrast agents and can be easily implemented.

Description

technical field [0001] The invention relates to a preparation method of a microbubble ultrasonic contrast agent. Background technique [0002] Microbubble contrast-enhanced ultrasound technology is to place drugs with relatively large side effects (such as anticancer drugs) in microbubbles, and release them locally in the target organ to protect the drug, delay the release of the drug, reduce the number of administrations, reduce the dose and increase the therapeutic purpose. At present, most of the natural polymer microbubble ultrasound contrast agents used clinically are derived from proteins such as albumin, which are not only expensive, but also have uneven particle size distribution, poor pressure resistance in the body, obvious sound attenuation, and short duration; Synthetic polymer microbubble contrast agents have good imaging effects, but the capsule wall is hard and requires high acoustic output, so that biological effects may occur when the microcapsules rupture....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/22
Inventor 戴志飞邢占文柯亨特王金锐刘吉斌刘绍琴
Owner HARBIN INST OF TECH
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