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A kind of construction method of core-shell structure

A construction method and core-shell structure technology, which can be applied in the direction of pharmaceutical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve problems such as limited degradability, incomplete degradation of silicon shells, and burden on the body , to achieve the effects of easy degradation, uniform particle size, and strong manufacturability

Active Publication Date: 2019-04-05
UNIV OF SCI & TECH OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the limited degradability of silica in the body environment, this strategy often results in incomplete degradation of the silica shell, resulting in a potential burden on the body.
In fact, there is currently no simple method that can simultaneously prevent leakage and completely degrade the two properties.

Method used

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  • A kind of construction method of core-shell structure
  • A kind of construction method of core-shell structure
  • A kind of construction method of core-shell structure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0075] Example 1 Nanoparticle ACC-HCPT loaded with ring-opened hydroxycamptothecin b 2 Preparation

[0076] Disperse 75.5 mg of anhydrous calcium chloride and 0.25 mL of water in 100 mL of ethanol, then put the resulting reaction solution into a 100 mL volume jar, seal it with a sealing film, and reserve a small hole; fill the ammonium bicarbonate Put it into a 20mL jar, seal it with a sealing film, and reserve a small hole; put the above-mentioned jar containing the reaction solution and the jar containing ammonium bicarbonate together in a vacuum desiccator, at 30°C Stand still for 12 hours under the environment; keep the obtained reaction solution in the jar, and directly add 0.25mL aqueous solution with composition of 8mg / mL hydroxycamptothecin and 32mg / mL sodium hydroxide; after stirring evenly, re-sealing Seal the mouth of the bottle with a film and reserve a small hole, then put the jar containing the reaction solution and the jar containing ammonium bicarbonate into a...

Embodiment 2

[0077] Example 2 Nanoparticles ACC-HCPT loaded with ring-opened hydroxycamptothecin b 6 preparation

[0078] Disperse 75.5 mg of anhydrous calcium chloride and 0.25 mL of water in 100 mL of ethanol, then put the resulting reaction solution into a 100 mL volume jar, seal it with a sealing film, and reserve a small hole; fill the ammonium bicarbonate Put it into a 20mL jar, seal it with a sealing film, and reserve a small hole; put the above-mentioned jar containing the reaction solution and the jar containing ammonium bicarbonate together in a vacuum desiccator, at 30°C Stand still for 12 hours under the environment; keep the obtained reaction solution in the jar, and directly add 0.25mL aqueous solution with composition of 24mg / mL hydroxycamptothecin and 32mg / mL sodium hydroxide; after stirring evenly, re-sealing Seal the mouth of the bottle with a film and reserve a small hole, then put the jar containing the reaction solution and the jar containing ammonium bicarbonate into...

Embodiment 3 2

[0079] Example 3 Preparation of Nanoparticles HCPT2@silica15 Coated with Silica and Loaded with Hydrophobic Drug Hydroxycamptothecin

[0080] The nanoparticles ACC-HCPT loaded with ring-opening hydroxycamptothecin prepared in Example 1 b 2 Disperse in 20mL ethanol solution, add 0.4mL ammonia water, 300μg EDTA, 15μL tetraethyl orthosilicate and 0.4mL water in sequence, and stir for 24 hours; Amorphous calcium carbonate-ring-opened hydroxycamptothecin nanoparticles ACC-HCPT with silica shell b 2 @silica15.

[0081] The above ACC-HCPT b 2@silica15 was dispersed in 5 mL of dilute hydrochloric acid with a concentration of 3.7%, centrifuged after standing for 2 hours, and the precipitate was washed with deionized water to obtain silica-coated nanoparticles HCPT2 loaded with hydrophobic drug hydroxycamptothecin @silica15. The appearance of the product is as Figure 5 , Figure 6 As shown, the particle size is uniform, about 110nm, in a monodisperse state.

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Abstract

The invention provides a construction method of a core-shell structure. The method comprises the following steps of (A) mixing an ethanol solution containing calcium ions and water and a core material to obtain a mixed solution, and reacting the mixed solution with a decomposition product of ammonium bicarbonate to obtain nanoparticles coated with calcium carbonate layers; and (B) mixing the nanoparticles coated with the calcium carbonate layers, ethanol, tetraethyl orthosilicate, ammonia water, water and ethylenediaminetetraacetic acid and then reacting to obtain the nanoparticles coated with silicon dioxide layers. By using layer-by-layer coating of amorphous calcium carbonate and silicon dioxide, the nano multi-layer core-shell structure is successfully prepared; for example, the core material as a drug-loaded core can be applied to drug loading and controlled release of the nanoparticles. By virtue of the novel technology, flexible control on the interlayer property of the amorphous calcium carbonate or the silicon dioxide can be achieved.

Description

technical field [0001] The invention relates to the technical field of nanostructure materials, in particular to a method for constructing a core-shell structure. Background technique [0002] As a classic nanostructure, the nano-multilayer core-shell structure has attracted extensive attention due to its special properties, making it widely researched and applied in many fields such as medicine, energy, and catalysis. At present, the preparation strategies of the core-shell multilayer structure mainly include micellar induction and etching, etc. The process is relatively complicated, and it is difficult to generate a core-shell structure with a large number of interlayers, and the ability to control the properties of the interlayer is insufficient, which limits the core-shell multilayer structure. Applications. [0003] As a form of natural mineral calcium carbonate that widely exists in nature, amorphous calcium carbonate has many advantages such as easy degradation, non-...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J13/22A61K47/69A61K47/52A61K31/4745A61P35/00B82Y40/00B82Y30/00A61K9/50A61K47/04A61K47/02
CPCA61K9/501A61K9/5073A61K31/4745B01J13/22B82Y30/00B82Y40/00
Inventor 俞书宏颜蓓蓓赵阳
Owner UNIV OF SCI & TECH OF CHINA
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