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Traditional Chinese medicine preparation for curing angiocardiopathy stent restenosis and preparation method thereof

A technology for the prevention and treatment of cardiovascular and stent restenosis, which is applied to cardiovascular system diseases, pharmaceutical formulas, medical preparations containing active ingredients, etc., can solve problems such as long duration of medication, poor patient compliance, and poor pertinence Anti-platelet aggregation, less toxic and side effects, and easy-to-manufacture effects

Inactive Publication Date: 2009-09-09
SHANDONG UNIV QILU HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main disadvantages of the above-mentioned clinical treatment status are lack of pertinence, unsatisfactory curative effect, long duration of medication, and poor patient compliance, which have become bottlenecks restricting clinical application.

Method used

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  • Traditional Chinese medicine preparation for curing angiocardiopathy stent restenosis and preparation method thereof

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Effect test

preparation example Construction

[0049] The preparation method of the dropping pill of the present invention comprises the following steps: 1500g Cyperus cyperi, 1500g Asarum, 1500g Chuanxiong and 1500g Radix Notoginseng add 36000g of water, put into a multifunctional extraction tank, keep the air pressure at 0.04-0.06mPa, decoct for 2 hours, extract its water-soluble components; repeat the above steps to extract again for 1.5 hours, and filter the extract through a 100-mesh sieve; use macroporous adsorption resin to refine the filtrate, and elute with ethanol; the eluate is concentrated under reduced pressure to a density of 1.33-1.35, wherein The input air pressure is 0.04-0.06mPa, the vacuum degree is -0.076~-0.088mPa, and stand for later use; the remaining medicinal materials are 1500g of Codonopsis pilosula, 1500g of Salvia miltiorrhiza, 1500g of safflower, 1500g of Bupleurum, 1500g of angelica, 1500g of red peony, 1500g of schisandra, and 1500g, Ophiopogon japonicus 1500g, Astragalus membranaceus 1500g, ...

Embodiment 1

[0073] Example 1: Patient Li, male, 56 years old, with a history of hypertension and coronary heart disease for 3 years, was discharged from the hospital after thrombolytic therapy due to acute myocardial infarction, but still had chest tightness, shortness of breath, fatigue, etc., and was bedridden for a long time, unable to get off the ground Activity, the condition worsened after a little activity, electrocardiogram showed old myocardial infarction, and ST segment changes, echocardiography showed left ventricular diastolic and systolic dysfunction, angiography showed coronary atherosclerosis, severe stenosis of blood vessels, RS occurred half a year after concurrent PCI, routine On the basis of treatment, take the Chinese medicine pill prepared according to the present invention, use the following formula:

[0074] Codonopsis 20g, Salvia miltiorrhiza 15g, safflower 20g, Cyperus cyperi 20g, Bupleurum 20g, Angelica 15g, Chishao 15g, Schisandra 10g, Panax notoginseng 20g, Asar...

Embodiment 2

[0076] Example 2: A patient with coronary heart disease, Feng X, female, 65 years old, had spontaneous angina pectoris due to coronary heart disease, and the effect of nitrate dilating drugs was not good. Coronary angiography showed coronary artery stenosis, and PTCA was performed, and the angina pectoris disappeared after the operation, but One year later, in-stent restenosis was treated with nitroglycerin and other treatments, and the angina pectoris was mild and sometimes severe. Later, Chinese medicine was added for treatment, and the following formula was used:

[0077] Codonopsis 10g, Salvia miltiorrhiza 15g, safflower 20g, Cyperus cyperi 20g, Bupleurum 10g, Angelica 15g, Chishao 10g, Schisandra 10g, Panax notoginseng 20g, Asarum 10g, Duhuo 10g, Ophiopogon japonicus 15g, Astragalus 10g, Polygala 10g, Qianghuo 10g, Caulis Spatholobus 10g, Atractylodes 10g, peach kernel 15g, ginkgo leaf 5g, chuanxiong 20g. Made into honey pills and taken. Three times a day, one pill each ...

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Abstract

The invention discloses a traditional Chinese medicine preparation for curing angiocardiopathy stent restenosis and a preparation method thereof. The traditional Chinese medicine preparation comprises various components according to the parts by weight: 10-30 parts of dangseng, 10-30 parts of the root of red-rooted salvia, 10-30 parts of safflower, 10-30 parts of rhizoma cyperi, 10-30 parts of radix bupleuri, 10-30 parts of angelica, 10-30 parts of red paeonia, 10-30 parts of schisandra chinensis, 10-30 parts of pseudo-ginseng, 10-30 parts of asarum, 10-30 parts of heracleum hemsleyanum michaux, 10-30 parts of ophiopogon root, 10-30 parts of milk weteh, 10-30 parts of polygala tenuifolia, 10-30 parts of notopterygium root, 10-30 parts of spatholobus stem, 10-30 parts of rhizoma atractylodis, 10-30 parts of peach kernel, 5-10 parts of folium ginkgo, and 10-30 parts of the rhizome of chuanxiong. The traditional Chinese medicine preparation can effectively inhibit vascular smooth muscle of cell proliferation, platelet aggregation and thrombosis, reduces the issue rejection reaction and inhibits inflammatory reaction.

Description

technical field [0001] The invention relates to a medical preparation containing components derived from plants, animals or minerals, in particular to a traditional Chinese medicine preparation for preventing restenosis of cardiovascular disease stents and a preparation method thereof. Background technique [0002] Coronary heart disease belongs to the category of "chest obstruction" in traditional Chinese medicine. From the observation of the tongue and pulse, it is mainly qi deficiency, and the signs of phlegm and blood stasis are mild. It belongs to the "heart obstruction" in traditional Chinese medicine. The etiology of coronary heart disease can be summed up as improper work and rest, overeating of glutinous food, or internal injury of the seven emotions, but these factors do not make everyone suffer from coronary heart disease, but are determined by the ups and downs of righteousness. And the morbidity is based on the elderly, and the diseases of the elderly are mostly...

Claims

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Application Information

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IPC IPC(8): A61K36/8968A61K9/20A61K9/10A61K9/48A61K9/00A61P9/10
Inventor 陈玉国徐峰李晓鲁李瑞建李传保张鹤吕瑞娟郝学喜
Owner SHANDONG UNIV QILU HOSPITAL
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