Belonging to the field of daily necessities, the invention relates to a toothpaste with yin nourishing, kidney tonifying, tooth strengthening, bactericidal, anti-inflammatory, analgesic and astringent effects. The toothpaste includes a Chinese medicinal additive obtained by supercritical CO2 extraction of a Chinese medicinal decoction piece composed of 10 of wine-treated rhubarb, 10 of carbon-treated rhubarb, 10 of gypsum, 10 of plaster, 5 of alum, 5 of dried alum, 10 of lake salt, 10 of salt, 10 of Davallia mariesii, 5 of silver Eucommia, 5 of Chinese angelica, 5 of eclipta alba, and 5 of pericarpium zanthoxyli. The Chinese medicinal additive has the yin nourishing, tooth strengthening, bactericidal, anti-inflammatory, analgesic and astringent functions. The Chinese medicinal additive, a moisturizing agent, an adhesive, a surfactant, a sweetener, other active additives and an aromatic agent together compose the toothpaste, wherein a friction agent is the Chinese medicinal decoction piece cuttlebone powder, which can remove humidity, relieve hyperacidity, stop bleeding, astringe sores, and can treat stomach and acid regurgitation, spitting of blood and hematochezia, infantile malnutrition sores, smelly and rotten variola, sores of vulvae, burns and scalds, double tongue in children, thrushes, paraglossa and bleeding, and throat impediment. The invention overcomes the defects of the existing technologies on the market and provides the multifunctional Chinese medicinal toothpaste with effective yin nourishing, kidney tonifying, tooth strengthening, bactericidal, anti-inflammatory, analgesic and astringent effects.