The invention discloses a comprehensive traditional Chinese medicine wine which comprises the following raw materials: herba siegesbeckiae, acanthopanax bark, angelica, futokadsura stem, clerodendrum trichotomum, erythrina bark, clematis root, cassia, homalomena rhizoma, rhizoma gastrodiae, heracleum hemsleyanum michaux, notopterygium root, chuanxiong rhizome, achyranthes root, gentiana macrophylla, zedoary, radix sileris, orientvine, mulberry twigs, loose knot, Chinese atractylodes, eucommia, teasel root, herb of common herons bill, mistletoe, sargentgloryvine stem, caulis sinomenii, Chinese starjasmine stem, corydalis tuber, Indian damnacanthus herb root, dioscorea nipponica, honeysuckle stem, spatholobus stem, bamboo brier, safflower, berba aristolochiae mollissimae, garden balsam stem, lycopodium clavatum, glabrous greenbrier rhizome, cassia twig, yam rhizome, elderberry and licorice root. The comprehensive traditional Chinese medicine wine is reasonable in compatibility of medicines, free of toxic or side effect and capable of fully exerting the curative effects of all Chinese herbal medicines, has favorable curative effects on cervical spondylosis, lumbar spondylosis, scapulohumeral periarthritis, rheumatism, rheumatoid arthritis, hyperosteogeny, traumatic injury and old wounds, and has an effective rate of more than 94%.